UCSF’s innovative, collaborative approach to patient care, research and education spans disciplines across the life sciences, making it a world leader in scientific discovery and its translation to improving health.
My research focuses on understanding the role of Gs-protein coupled receptor signaling in skeletal development, with a focused interest in craniofacial fibrous dysplasia of the bone (FD) and McCune-Albright syndrome (MAS).
The unifying theme of my research is to understand the genetic mechanisms involved in the development and progression of melanocytic skin tumors and harness our understanding to improve melanoma treatment. I am well positioned to accomplish this goal since I am an expert dermatopathologist and a scientist with expertise in cancer genetics and bioinformatics. My efforts have been focused on identifying oncogenic drivers in melanocytic tumors, with the goal to identify and move new knowledge from the laboratory directly to patient care.
I am a radiation oncologist who specializes in the treatment of head and neck, lung, and skin cancers. I serve on national guidelines committees outlining the best practices for these cancers. I design clinical trials to improve treatment of these cancers. I give lectures and design courses to help others learn more about how to best treat these cancers. I am a journal editor and interested in publishing the best scientific research on these diseases.
I am a Pulmonary and Critical Care Physician-Scientist. My clinical and research specialties are in Cystic Fibrosis lung infection and inflammation. I am the Principal Investigator of a basic science laboratory, and I serve as the Associate Program director of the UCSF Adult Cystic Fibrosis Center. I attend regularly in the ICUs at Parnassus and Mount Zion and am passionate about improving medical education particularly during COVID when our learners have faced unforeseen challenges.
Our laboratory is interested in understanding how B cell behavior is regulated after encounter with either “self” or “foreign” antigens. We postulate that overlapping mechanisms are at play in both scenarios. The lab seeks to define the rules that govern B cell responses to specific features of foreign antigens, including antigen affinity, valency and co-stimulatory signals. We are also interested in how the clonal composition of both the pre- and post-immune B cell repertoires is regulated.
