UCSF’s innovative, collaborative approach to patient care, research and education spans disciplines across the life sciences, making it a world leader in scientific discovery and its translation to improving health.
I am a dermatologist, microbiologist, and immunologist and currently serve as a Professor and the Vice Chair of Research in the Department of Dermatology. I dedicate 80% of my time to research and the remaining time taking care of patients with severe inflammatory skin diseases. The central focus of my laboratory is to investigate the cellular and molecular mechanisms that mediate interactions between bacteria and the developing immune system, with a long-term goal of developing new therapeutic approaches based on this knowledge.
Autoimmune rheumatic diseases, which constitute a broad range of chronic illnesses, cause significant morbidity and mortality in the US and worldwide. T cell receptor (TCR) recognition and signaling have long be recognized to play a critical role in the pathogenesis of autoimmune diseases. However, how altered TCR signaling strength affects immune tolerance and promotes autoimmunity remains incompletely understood. Dr.
Dr. Singer is an attending physician and Associate Professor in Radiation Oncology at UCSF, where she specializes in the use of radiation to treat breast cancer, thoracic cancer, and ventricular tachycardia. She also serves as Clinical Magnetic Resonance Imaging (MRI) Director in Radiation Oncology and is board-certified in both radiation oncology and MRI safety.
My laboratory focuses on identification of therapeutic resistance mechanisms and novel treatment strategies for acute myeloid leukemia (AML). We have a particular emphasis on AML associated with mutations in Fms-like Tyrosine Kinase-3 (FLT3). FLT3 is mutated in ~30% of AML, with constitutively activating FLT3 internal tandem duplication (ITD) mutations conferring a poor prognosis.
Julie Ann Sosa, MD, MA, FACS, MAMSE, FSSO, is the Leon Goldman MD Distinguished Professor of Surgery and Chair of the Department of Surgery at the University of California San Francisco (UCSF), where she is also a Professor in the Department of Medicine and affiliated faculty for the Philip R. Lee Institute for Health Policy Studies. Dr. Sosa came to UCSF in 2018 from Duke. Her clinical interest is in endocrine surgery, with a focus in thyroid cancer.
Dr. Sundaram is a biomedical engineer, physician, and scientist with an interest in airway smooth muscle biology. Her laboratory focuses on tethering pathways used by muscle to transmit force. Through a more nuanced understanding of pathways that contribute to force transmission and the influence on pro-inflammatory cytokines on regulating these pathways, Dr. Sundaram hopes to identify novel drug targets to mitigate exaggerated airway narrowing in chronic airways diseases.
Dr. Jane Symington is a pediatric physician scientist investigating the pathogenesis of Coccidioides, the fungus that causes Coccidioidomycosis, more commonly known as Valley Fever. Her current work focuses on dissecting the interactions between Coccidioides and innate immune cells to identify and target pathways important for fungal virulence or protective host responses.
Our lab leverages cutting-edge machine learning and experimental genomics to map the gene regulatory networks disrupted in cardiovascular disease and discover network-correcting therapeutics. We develop machine learning models that leverage the unprecedented volume of transcriptomic and epigenomic data now available to gain a fundamental understanding of network dynamics that can be democratized to a vast array of downstream applications.
