Jane Symington, MD, PhD

Assistant Adjunct Professor
Pediatrics
[email protected]

Dr. Jane Symington is a pediatric physician scientist investigating the pathogenesis of Coccidioides, the fungus that causes Coccidioidomycosis, more commonly known as Valley Fever. Her current work focuses on dissecting the interactions between Coccidioides and innate immune cells to identify and target pathways important for fungal virulence or protective host responses.

Publications: 

Genome-scale CRISPR screening reveals that C3aR signaling is critical for rapid capture of fungi by macrophages.

PLoS pathogens

Cohen A, Jeng EE, Voorhies M, Symington J, Ali N, Rodriguez RA, Bassik MC, Sil A

A non-canonical autophagy-dependent role of the ATG16L1T300A variant in urothelial vesicular trafficking and uropathogenic Escherichia coli persistence.

Autophagy

Wang C, Bauckman KA, Ross ASB, Symington JW, Ligon MM, Scholtes G, Kumar A, Chang HW, Twentyman J, Fashemi BE, Xavier RJ, Mysorekar IU

ATG16L1 deficiency in macrophages drives clearance of uropathogenic E. coli in an IL-1β-dependent manner.

Mucosal immunology

Symington JW, Wang C, Twentyman J, Owusu-Boaitey N, Schwendener R, Núñez G, Schilling JD, Mysorekar IU

Estrogenic modulation of uropathogenic Escherichia coli infection pathogenesis in a murine menopause model.

Infection and immunity

Wang C, Symington JW, Ma E, Cao B, Mysorekar IU

ATG16L1 and pathogenesis of urinary tract infections.

Autophagy

Wang C, Symington JW, Mysorekar IU

Atg16L1 deficiency confers protection from uropathogenic Escherichia coli infection in vivo.

Proceedings of the National Academy of Sciences of the United States of America

Wang C, Mendonsa GR, Symington JW, Zhang Q, Cadwell K, Virgin HW, Mysorekar IU