Aparna Sundaram, MD

Assoc Professor in Residence
Medicine
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Dr. Sundaram is a biomedical engineer, physician, and scientist with an interest in airway smooth muscle biology. Her laboratory focuses on tethering pathways used by muscle to transmit force. Through a more nuanced understanding of pathways that contribute to force transmission and the influence on pro-inflammatory cytokines on regulating these pathways, Dr. Sundaram hopes to identify novel drug targets to mitigate exaggerated airway narrowing in chronic airways diseases. Her work leverages ex vivo and in vivo disease models, transgenic mouse models, and advanced microscopy to map force transmission pathways on a cellular level.

Dr. Sundaram also attends in the Moffitt-Long Intensive Care Units. She serves as the Associate Director for the Molecular Medicine Residency Program. Her primary interests in physician-scientist training are related to longitudinal mentoring, work-life integration, and supporting women and minorities in science.

Publications: 

Integrin a2ß1 regulates collagen I tethering to modulate hyperresponsiveness in reactive airway disease models.

The Journal of clinical investigation

Liu S, Ngo U, Tang XZ, Ren X, Qiu W, Huang X, DeGrado W, Allen CD, Jo H, Sheppard D, Sundaram AB

Dual antagonists of a5ß1/avß1 integrin for airway hyperresponsiveness.

Bioorganic & medicinal chemistry letters

Sundaram A, Chen C, Isik Reed N, Liu S, Ki Yeon S, McIntosh J, Tang YZ, Yang H, Adler M, Beresis R, Seiple IB, Sheppard D, DeGrado WF, Jo H

G protein-regulated endocytic trafficking of adenylyl cyclase type 9.

eLife

Lazar AM, Irannejad R, Baldwin TA, Sundaram AB, Gutkind JS, Inoue A, Dessauer CW, Von Zastrow M

A disease-associated mutation in fibrillin-1 differentially regulates integrin-mediated cell adhesion.

The Journal of biological chemistry

Del Cid JS, Reed NI, Molnar K, Liu S, Dang B, Jensen SA, DeGrado W, Handford PA, Sheppard D, Sundaram AB

IL-17A Recruits Rab35 to IL-17R to Mediate PKCa-Dependent Stress Fiber Formation and Airway Smooth Muscle Contractility.

Journal of immunology (Baltimore, Md. : 1950)

Bulek K, Chen X, Parron V, Sundaram A, Herjan T, Ouyang S, Liu C, Majors A, Zepp J, Gao J, Dongre A, Bodaszewska-Lubas M, Echard A, Aronica M, Carman J, Garantziotis S, Sheppard D, Li X

Targeting integrin a5ß1 ameliorates severe airway hyperresponsiveness in experimental asthma.

The Journal of clinical investigation

Sundaram A, Chen C, Khalifeh-Soltani A, Atakilit A, Ren X, Qiu W, Jo H, DeGrado W, Huang X, Sheppard D

G Protein-Coupled Receptor Endocytosis Confers Uniformity in Responses to Chemically Distinct Ligands.

Molecular pharmacology

Tsvetanova NG, Trester-Zedlitz M, Newton BW, Riordan DP, Sundaram AB, Johnson JR, Krogan NJ, von Zastrow M

IQGAP1-dependent scaffold suppresses RhoA and inhibits airway smooth muscle contraction.

The Journal of clinical investigation

Bhattacharya M, Sundaram A, Kudo M, Farmer J, Ganesan P, Khalifeh-Soltani A, Arjomandi M, Atabai K, Huang X, Sheppard D

The phosphatase CD148 promotes airway hyperresponsiveness through SRC family kinases.

The Journal of clinical investigation

Katsumoto TR, Kudo M, Chen C, Sundaram A, Callahan EC, Zhu JW, Lin J, Rosen CE, Manz BN, Lee JW, Matthay MA, Huang X, Sheppard D, Weiss A

The avß6 integrin modulates airway hyperresponsiveness in mice by regulating intraepithelial mast cells.

The Journal of clinical investigation

Sugimoto K, Kudo M, Sundaram A, Ren X, Huang K, Bernstein X, Wang Y, Raymond WW, Erle DJ, Abrink M, Caughey GH, Huang X, Sheppard D