Julia Carnevale, MD

Asst. In Residence Professor
Medicine

Dr. Carnevale is a physician-scientist who treats patients with gastrointestinal cancers, and also performs research into finding novel therapies for these diseases.

Publications: 

CLDN18.2 chimeric antigen receptor T cell therapy for patients with advanced gastric and pancreatic adenocarcinoma: Results of ELIMYN18.2 phase 1b clinical trial.

Journal of Clinical Oncology

Gregory P. Botta, Ronan Joseph Kelly, Zhaohui Jin, Hong Ma, Geoffrey Yuyat Ku, Dan Zhao, Rutika Mehta, Julia C. Carnevale, Gloria Sierra, Jie JIA, Raffaele Baffa, Zhonghai Li, Dae Won Kim, Harry H. Yoon

Ablation of Cullin-5 in Primary Human T Cells Improves Tumor Killing and Persistence in BCMA-Targeting CAR-T Cells in a Multiple Myeloma Model.

Blood

Stefanie Bachl, Alexis Talbot, Carter Ching, Nupura Kale, Zhongmei Li, Morgan Diolaiti, Amy Peixin Chen, Joseph Muldoon, Chang Liu, Thomas Martin, Justin Eyquem, Julia Carnevale

Modular pooled discovery of synthetic knockin sequences to program durable cell therapies.

Cell

Blaeschke F, Chen YY, Apathy R, Daniel B, Chen AY, Chen PA, Sandor K, Zhang W, Li Z, Mowery CT, Yamamoto TN, Nyberg WA, To A, Yu R, Bueno R, Kim MC, Schmidt R, Goodman DB, Feuchtinger T, Eyquem J, Jimmie Ye C, Carnevale J, Satpathy AT, Shifrut E, Roth TL, Marson A

Abstract No. 266 Phase I Prospective Trial of TAS-102 (Trifluridine and Tipiracil) and Radioembolization with 90Y Resin Microspheres for Chemo-Refractory Colorectal Liver Metastases.

Journal of Vascular and Interventional Radiology

N. Fidelman, C. Atreya, M. Griffith, A. Milloy, J. Carnevale, A. Venook, K. Van Loon

Resistance to ATR Inhibitors Is Mediated by Loss of the Nonsense-Mediated Decay Factor UPF2.

Cancer research

O'Leary PC, Chen H, Doruk YU, Williamson T, Polacco B, McNeal AS, Shenoy T, Kale N, Carnevale J, Stevenson E, Quigley DA, Chou J, Feng FY, Swaney DL, Krogan NJ, Kim M, Diolaiti ME, Ashworth A

RASA2 ablation in T cells boosts antigen sensitivity and long-term function.

Nature

Carnevale J, Shifrut E, Kale N, Nyberg WA, Blaeschke F, Chen YY, Li Z, Bapat SP, Diolaiti ME, O'Leary P, Vedova S, Belk J, Daniel B, Roth TL, Bachl S, Anido AA, Prinzing B, Ibañez-Vega J, Lange S, Haydar D, Luetke-Eversloh M, Born-Bony M, Hegde B, Kogan S, Feuchtinger T, Okada H, Satpathy AT, Shannon K, Gottschalk S, Eyquem J, Krenciute G, Ashworth A, Marson A

Genome-wide CRISPR screens of T cell exhaustion identify chromatin remodeling factors that limit T cell persistence.

Cancer cell

Belk JA, Yao W, Ly N, Freitas KA, Chen YT, Shi Q, Valencia AM, Shifrut E, Kale N, Yost KE, Duffy CV, Daniel B, Hwee MA, Miao Z, Ashworth A, Mackall CL, Marson A, Carnevale J, Vardhana SA, Satpathy AT

Phase II study of pembrolizumab plus capecitabine and bevacizumab in microsatellite stable (MSS) metastatic colorectal cancer (mCRC).

Journal of Clinical Oncology

Andrea Grace Bocobo, Renee Wang, Spencer Behr, Julia C. Carnevale, Pelin Cinar, Eric Andrew Collisson, Lawrence Fong, Bridget P Keenan, Wesley Allen Kidder, Andrew H. Ko, Kanti Pallav Kolli, Megan Kennedy, Angela Laffan, Sorbarikor Piawah, Marin Pollak, Gabriel Schwartz, Julia Whitman, Li Zhang, Katherine Van Loon, Chloe Evelyn Atreya

The Additional Diagnostic Benefit of Pancreatic Cancer Molecular Profiling After Germline Testing.

Pancreas

Walker EJ, Blanco AM, Carnevale J, Cinar P, Collisson EA, Tempero MA, Ko AH

Hypoxia is a dominant remodeler of the effector T cell surface proteome relative to activation and regulatory T cell suppression.

Molecular & cellular proteomics : MCP

Byrnes JR, Weeks AM, Shifrut E, Carnevale J, Kirkemo L, Ashworth A, Marson A, Wells JA

Implementation of an Embedded In-Clinic Genetic Testing Station to Optimize Germline Testing for Patients with Pancreatic Adenocarcinoma.

The oncologist

Walker EJ, Goldberg D, Gordon KM, Pedley C, Carnevale J, Cinar P, Collisson EA, Tempero MA, Ko AH, Blanco AM, Dhawan M

512O Interim results from a phase II study of the ATR inhibitor ceralasertib in ARID1A-deficient and ARID1A-intact advanced solid tumor malignancies.

Annals of Oncology

R. Aggarwal, S. Umetsu, M. Dhawan, J. Grabowsky, J. Carnevale, M. Howell, L. Wilch, J. Chapman, E. Alvarez, S. Calabrese, S. Smith, N. Shah, E. Dean, P. Munster, E. Collisson

Investigating tumor molecular profiling as a possible contributor to racial/ethnic disparities in pancreatic cancer.

Journal of Clinical Oncology

Evan Justin Walker, Sorbarikor Piawah, Ann Griffin, Julia C. Carnevale, Pelin Cinar, Eric Andrew Collisson, Margaret A. Tempero, Andrew H. Ko

The marginal diagnostic benefit of pancreatic cancer molecular profiling after germline testing.

Journal of Clinical Oncology

Evan Justin Walker, Amie Blanco, Julia C. Carnevale, Pelin Cinar, Eric Andrew Collisson, Margaret A. Tempero, Andrew H. Ko

Phase II study of pembrolizumab plus capecitabine and bevacizumab in microsatellite stable (MSS) metastatic colorectal cancer (mCRC): Interim analysis.

Journal of Clinical Oncology

Andrea Grace Bocobo, Renee Wang, Spencer Behr, Julia C. Carnevale, Pelin Cinar, Eric Andrew Collisson, Lawrence Fong, Wesley Allen Kidder, Andrew H. Ko, Kanti Pallav Kolli, Megan Kennedy, Angela Laffan, Sheila Lindsay, Sneha Nalla, Gabriel Schwartz, Julia Whitman, Patricia Zendejas, Li Zhang, Katherine Van Loon, Chloe Evelyn Atreya

Combined Immunotherapy and Hypofractionated Radiotherapy for Metastatic Cancers.

International Journal of Radiation Oncology • Biology • Physics

S. Sinha, C. Greene, R.K. Kelley, P. Cinar, A.P. Venook, C. Atreya, J. Gordan, J. Carnevale, M. Anwar, M. Feng

Abstract PR08: Discovery of immune regulators in primary human T cells using genome-wide CRISPR screens.

Cancer immunology research

Julia Carnevale, Eric Shifrut, Victoria Tobin, Theodore Roth, Jonathan Woo, Christina Bui, Jonathan Li, Morgan Diolaiti, Alan Ashworth, Alexander Marson

3:54 PM Abstract No. 243 Phase I Prospective Trial of TAS-102 (trifluride and tipiracil) and radioembolization with 90Y resin microspheres for chemo-refractory colorectal liver metastases.

Journal of Vascular and Interventional Radiology

N. Fidelman, C. Atreya, M. Griffith, A. Milloy, J. Carnevale, P. Cinar, A. Venook, K. Van Loon

Phase I prospective trial of TAS-102 (trifluride and tipiracil) and radioembolization with 90Y resin microspheres for chemo-refractory colorectal liver metastases.

Journal of Clinical Oncology

Nicholas Fidelman, Chloe Evelyn Atreya, Madeline J Griffith, Marion Alexandra Milloy, Julia C. Carnevale, Pelin Cinar, Alan P. Venook, Katherine Van Loon

Genome-wide CRISPR Screens in Primary Human T Cells Reveal Key Regulators of Immune Function.

The Journal of Immunology

Eric Shifrut, Julia Carnevale, Alan Ashworth, Alexander Marson

Referral frequency, attrition rate, and outcomes of germline testing in patients with pancreatic adenocarcinoma.

Familial cancer

Walker EJ, Carnevale J, Pedley C, Blanco A, Chan S, Collisson EA, Tempero MA, Ko AH

Genome-wide CRISPR Screens in Primary Human T Cells Reveal Key Regulators of Immune Function.

Cell

Shifrut E, Carnevale J, Tobin V, Roth TL, Woo JM, Bui CT, Li PJ, Diolaiti ME, Ashworth A, Marson A

Reprogramming human T cell function and specificity with non-viral genome targeting.

Nature

Roth TL, Puig-Saus C, Yu R, Shifrut E, Carnevale J, Li PJ, Hiatt J, Saco J, Krystofinski P, Li H, Tobin V, Nguyen DN, Lee MR, Putnam AL, Ferris AL, Chen JW, Schickel JN, Pellerin L, Carmody D, Alkorta-Aranburu G, Del Gaudio D, Matsumoto H, Morell M, Mao Y, Cho M, Quadros RM, Gurumurthy CB, Smith B, Haugwitz M, Hughes SH, Weissman JS, Schumann K, Esensten JH, May AP, Ashworth A, Kupfer GM, Greeley SAW, Bacchetta R, Meffre E, Roncarolo MG, Romberg N, Herold KC, Ribas A, Leonetti MD, Marson A

Referral patterns and attrition rate for germline testing in pancreatic cancer (PC) patients.

Journal of Clinical Oncology

Evan Justin Walker, Julia C. Carnevale, Christina Pedley, Amie Blanco, Salina Chan, Eric Andrew Collisson, Andrew H. Ko

Targeting the Tumor Microenvironment.

Current and Emerging Therapies in Pancreatic Cancer

Julia Carnevale, Andrew H. Ko

The Challenge of Primary Central Nervous System Lymphoma.

Hematology/oncology clinics of North America

Carnevale J, Rubenstein JL

Assessing the Significance of BRCA1 and BRCA2 Mutations in Pancreatic Cancer.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Carnevale J, Ashworth A

Exploring the association of succinate dehydrogenase complex mutations with lymphoid malignancies.

Familial cancer

Renella R, Carnevale J, Schneider KA, Hornick JL, Rana HQ, Janeway KA

Progress in central nervous system lymphomas.

British journal of haematology

Wang CC, Carnevale J, Rubenstein JL

SYK regulates mTOR signaling in AML.

Leukemia

Carnevale J, Ross L, Puissant A, Banerji V, Stone RM, DeAngelo DJ, Ross KN, Stegmaier K

The crimson care collaborative: a student-faculty initiative to increase medical students' early exposure to primary care.

Academic medicine : journal of the Association of American Medical Colleges

Berman R, Powe C, Carnevale J, Chao A, Knudsen J, Nguyen A, Edgman-Levitan S

Knowledge base and caretaker-child communication about HIV in peri-urban schoolchildren of Lusaka, Zambia.

AIDS care

Carnevale J, Gropper AB, Agnew-Blais J, Mimiaga MJ, Mhango A, Bail R, Ngoma M

Schistosomiasis haematobium prevalence and risk factors in a school-age population of peri-urban Lusaka, Zambia.

Journal of tropical pediatrics

Agnew-Blais J, Carnevale J, Gropper A, Shilika E, Bail R, Ngoma M

The development of sentence interpretation: effects of perceptual, attentional and semantic interference.

Developmental science

Leech R, Aydelott J, Symons G, Carnevale J, Dick F