Yvonne Ou, MD

Professor in Residence

Our laboratory studies the cellular and synaptic mechanisms of glaucomatous neurodegeneration. We are particularly interested in understanding the earliest steps of inner retina circuit disassembly in response to injury. Our research program combines imaging and analysis of specific cell and synaptic labels in the retina, rodent models of experimental glaucoma, novel genetic tools in which specific cell types are labeled, and the tools of molecular/cell biology and physiology to address a series of questions that, unanswered, have prevented progress in the field: 1) What are the early steps of compartmentalized neurodegeneration of the ganglion cell in glaucoma? 2) Are there specific ganglion cell types that are more susceptible to intraocular pressure (IOP) elevation? 3) Are there specific inner retinal circuits that are more susceptible to IOP elevation? As a clinician-scientist, I am motivated to advance our field not only by answering these fundamental questions, but also by translating the knowledge gained into improvements in diagnostic and treatment modalities in glaucoma. For example, a detailed understanding of the earliest structural and functional changes that occur in glaucoma will allow us to design treatments that can rescue RGCs, perhaps the most susceptible RGCs, before irreversible cell death occurs. Our long-term goal is to understand the mechanisms underlying ganglion cell degeneration and circuit remodeling in glaucoma in order to improve diagnosis and treatment.


Aqueous Shunts with Extraocular Reservoir for Open-Angle Adult Glaucoma: A Report by the American Academy of Ophthalmology.


Chopra V, Takusagawa HL, Rosdahl JA, Sit AJ, Richter GM, Ou Y, Kim SJ, WuDunn D

Central Visual Field Testing in Early Glaucoma: A Report by the American Academy of Ophthalmology.


WuDunn D, Takusagawa HL, Rosdahl JA, Sit AJ, Chopra V, Ou Y, Richter GM, Knight OJ, Solá-Del Valle D, Kim SJ

Trabecular Procedures Combined with Cataract Surgery for Open-Angle Glaucoma: A Report by the American Academy of Ophthalmology.


Richter GM, Takusagawa HL, Sit AJ, Rosdahl JA, Chopra V, Ou Y, Kim SJ, WuDunn D

Retinal ganglion cell repopulation for vision restoration in optic neuropathy: a roadmap from the RReSTORe Consortium.

Molecular neurodegeneration

Soucy JR, Aguzzi EA, Cho J, Gilhooley MJ, Keuthan C, Luo Z, Monavarfeshani A, Saleem MA, Wang XW, Wohlschlegel J, RReSTORe Consortium, Baranov P, Di Polo A, Fortune B, Gokoffski KK, Goldberg JL, Guido W, Kolodkin AL, Mason CA, Ou Y, Reh TA, Ross AG, Samuels BC, Welsbie D, Zack DJ, Johnson TV

Selective Laser Trabeculoplasty for the Treatment of Glaucoma: A Report by the American Academy of Ophthalmology.


Takusagawa HL, Hoguet A, Sit AJ, Rosdahl JA, Chopra V, Ou Y, Richter G, Kim SJ, WuDunn D

The Retinal Ganglion Cell Repopulation, Stem Cell Transplantation, and Optic Nerve Regeneration Consortium.

Ophthalmology science

Johnson TV, Baranov P, Di Polo A, Fortune B, Gokoffski KK, Goldberg JL, Guido W, Kolodkin AL, Mason CA, Ou Y, Reh TA, Ross AG, Samuels BC, Zack DJ

Assessment of Remote Training, At-Home Testing, and Test-Retest Variability of a Novel Test for Clustered Virtual Reality Perimetry.

Ophthalmology. Glaucoma

Chia ZK, Kong AW, Turner ML, Saifee M, Damato BE, Backus BT, Blaha JJ, Schuman JS, Deiner M, Ou Y

Anterior segment optical coherence tomography for detection of narrow angles: a community-based diagnostic accuracy study.

Ophthalmology. Glaucoma

Pradhan S, Sah RK, Bhandari G, Bhandari S, Byanju R, Kandel RP, Thompson IJ, Stevens VM, Aromin KM, Oatts JT, Ou Y, Lietman TM, O'Brien KS, Keenan JD

Relationship Between Intraocular Pressure and Age: A Population-Based Study in Nepal.

Journal of glaucoma

Bhandari G, Bhandari S, Byanju R, Pradhan S, Sah RK, Kandel RP, Thompson IJ, Rotchford AP, West SK, Muñoz B, Stevens VM, Oatts JT, Ou Y, Lietman TM, O'Brien KS, Keenan JD

Corneal Hysteresis for the Diagnosis of Glaucoma and Assessment of Progression Risk: A Report by the American Academy of Ophthalmology.


Sit AJ, Chen TC, Takusagawa HL, Rosdahl JA, Hoguet A, Chopra V, Richter GM, Ou Y, Kim SJ, WuDunn D


Ophthalmology. Glaucoma

Ou Y, Turner M

Randomized Trial to Evaluate the Efficacy of the Nanodropper Device for Pupillary Dilation and Cycloplegia in Children.


Hoppe CB, Yonamine S, Kao BW, Turner ML, Ou Y, Han Y, Keenan JD, Oatts JT

At-Home Glaucoma Monitoring: Is it Ready for Prime Time?

Ophthalmology. Glaucoma

Turner M, Ou Y

A Global and Sector-Based Comparison of OCT Angiography and Visual Field Defects in Glaucoma.

Journal of ophthalmology

Kong AW, Turner ML, Saifee M, Jethi M, Mora M, Ou Y

Virtual Reality Oculokinetic Perimetry Test Reproducibility and Relationship to Conventional Perimetry and OCT.

Ophthalmology science

Greenfield JA, Deiner M, Nguyen A, Wollstein G, Damato B, Backus BT, Wu M, Schuman JS, Ou Y

Individuals with and without normal tension glaucoma exhibit comparable performance on tests of cognitive function.

International journal of ophthalmology

Cui QN, Green D, Jethi M, Driver T, Porco TC, Kuo J, Lin SC, Stamper RL, Han Y, Chiu CS, Ramanathan S, Ward ME, Possin K, Ou Y

Disassembly and rewiring of a mature converging excitatory circuit following injury.

Cell reports

Della Santina L, Yu AK, Harris SC, Soliño M, Garcia Ruiz T, Most J, Kuo YM, Dunn FA, Ou Y

Asymmetric Functional Impairment of ON and OFF Retinal Pathways in Glaucoma.

Ophthalmology science

Kong AW, Turner ML, Chan H, Stamper RL, Arnold BF, Della Santina L, Ou Y

Probing ON and OFF Retinal Pathways in Glaucoma Using Electroretinography.

Translational vision science & technology

Kong AW, Della Santina L, Ou Y

Neurotrophic keratitis after micropulse transscleral diode laser cyclophotocoagulation.

American journal of ophthalmology case reports

Perez CI, Han Y, Rose-Nussbaumer J, Ou Y, Hsia YC

Partial Cone Loss Triggers Synapse-Specific Remodeling and Spatial Receptive Field Rearrangements in a Mature Retinal Circuit.

Cell reports

Care RA, Kastner DB, De la Huerta I, Pan S, Khoche A, Della Santina L, Gamlin C, Santo Tomas C, Ngo J, Chen A, Kuo YM, Ou Y, Dunn FA

Reduced contrast sensitivity among older women is associated with increased risk of cognitive impairment.

Annals of neurology

Ward ME, Gelfand JM, Lui LY, Ou Y, Green AJ, Stone K, Pedula KL, Cummings SR, Yaffe K

Biolistic Labeling of Retinal Ganglion Cells.

Methods in molecular biology (Clifton, N.J.)

Santina LD, Ou Y

Establishment and Characterization of an Acute Model of Ocular Hypertension by Laser-Induced Occlusion of Episcleral Veins.

Investigative ophthalmology & visual science

Zhang L, Li G, Shi M, Liu HH, Ge S, Ou Y, Flanagan JG, Chen L

Surgical Management of Pediatric Glaucoma.

Developments in ophthalmology

Chang I, Caprioli J, Ou Y

Genetic dissection of anterior segment dysgenesis caused by a Col4a1 mutation in mouse.

Disease models & mechanisms

Mao M, Kiss M, Ou Y, Gould DB

Selective Vulnerability of Specific Retinal Ganglion Cell Types and Synapses after Transient Ocular Hypertension.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Ou Y, Jo RE, Ullian EM, Wong RO, Della Santina L

Correlation of Serial Scleral and Corneal Pneumatonometry.


Kuo DS, Ou Y, Jeng BH, Bhisitkul R, Stewart JM, Duncan JL, Han Y

Expert Review of Ophthalmology

Towards the development of a human glaucoma disease-in-a-dish model using stem cells

Green DI
Ou Y

Scleral intraocular pressure measurement in cadaver eyes pre- and postkeratoprosthesis implantation.

Investigative ophthalmology & visual science

Lin CC, Chen A, Jeng BH, Porco TC, Ou Y, Han Y

Development of a resident training module for systematic optic disc evaluation in glaucoma.

Journal of glaucoma

Law SK, Tamboli DA, Ou Y, Giaconi JA, Caprioli J

Glaucoma, Alzheimer disease and other dementia: a longitudinal analysis.

Ophthalmic epidemiology

Ou Y, Grossman DS, Lee PP, Sloan FA

Surgical management of pediatric glaucoma.

Developments in ophthalmology

Ou Y, Caprioli J

Outcomes of Ahmed glaucoma valve implantation in children with primary congenital glaucoma.

Archives of ophthalmology (Chicago, Ill. : 1960)

Ou Y, Yu F, Law SK, Coleman AL, Caprioli J

Transcriptional modification by a CASK-interacting nucleosome assembly protein.


Wang GS, Hong CJ, Yen TY, Huang HY, Ou Y, Huang TN, Jung WG, Kuo TY, Sheng M, Wang TF, Hsueh YP