Ursula Lang, MD, PhD

Alumni (Pathology)
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Publications: 

Epigenetic reprogramming shapes the cellular landscape of schwannoma.

Nature communications

Liu SJ, Casey-Clyde T, Cho NW, Swinderman J, Pekmezci M, Dougherty MC, Foster K, Chen WC, Villanueva-Meyer JE, Swaney DL, Vasudevan HN, Choudhury A, Pak J, Breshears JD, Lang UE, Eaton CD, Hiam-Galvez KJ, Stevenson E, Chen KH, Lien BV, Wu D, Braunstein SE, Sneed PK, Magill ST, Lim D, McDermott MW, Berger MS, Perry A, Krogan NJ, Hansen MR, Spitzer MH, Gilbert L, Theodosopoulos PV, Raleigh DR

Painful Mucosal Ulcerations in a Patient With HIV.

JAMA dermatology

Kusari A, Lang UE, Chang AY

LZTS2: A novel and independent prognostic biomarker for clear cell renal cell carcinoma.

Pathology, research and practice

Peng Y, Greenland NY, Lang UE, Stohr BA

BRAFV600E induces reversible mitotic arrest in human melanocytes via microrna-mediated suppression of AURKB.

eLife

McNeal AS, Belote RL, Zeng H, Urquijo M, Barker K, Torres R, Curtin M, Shain AH, Andtbacka RH, Holmen S, Lum DH, McCalmont TH, VanBrocklin MW, Grossman D, Wei ML, Lang UE, Judson-Torres RL

A 21-Year-Old Woman with Joint Pain and Skin Ulceration.

Arthritis care & research

French S, Lang U, Margaretten M

Human melanocyte development and melanoma dedifferentiation at single-cell resolution.

Nature cell biology

Belote RL, Le D, Maynard A, Lang UE, Sinclair A, Lohman BK, Planells-Palop V, Baskin L, Tward AD, Darmanis S, Judson-Torres RL

Association of Facial Pustular Neutrophilic Eruption With Messenger RNA-1273 SARS-CoV-2 Vaccine.

JAMA dermatology

Merrill ED, Kashem SW, Amerson EH, Pincus LB, Lang UE, Shinkai K, Chang AY

Primary Cilia Are Preserved in Cellular Blue and Atypical Blue Nevi and Lost in Blue Nevus-like Melanoma.

The American journal of surgical pathology

Sheahon KM, Jankowski T, Yeh I, North JP, Pincus LB, LeBoit PE, McCalmont TH, Lang UE

BAP1-inactivated melanocytic tumors show prominent centrosome amplification and associated loss of primary cilia.

Journal of cutaneous pathology

Ye J, Sheahon KM, LeBoit PE, McCalmont TH, Lang UE

Herpes simplex virus-2 associated with a large fungating penile mass.

Urology case reports

Bowman MS, Lang UE, Leslie KS, Amend G, Breyer BN

Meningioma cells express primary cilia but do not transduce ciliary Hedgehog signals.

Acta neuropathologica communications

Findakly S, Choudhury A, Daggubati V, Pekmezci M, Lang UE, Raleigh DR

Clinical Implications of Primary Cilia in Skin Cancer.

Dermatology and therapy

Choudhury A, Neumann NM, Raleigh DR, Lang UE

Ciliation Index Is a Useful Diagnostic Tool in Challenging Spitzoid Melanocytic Neoplasms.

The Journal of investigative dermatology

Lang UE, Torres R, Cheung C, Vladar EK, McCalmont TH, Kim J, Judson-Torres RL

Use of the Ciliation Index to Distinguish Invasive Melanoma From Associated Conventional Melanocytic Nevi.

The American Journal of dermatopathology

Lang UE, Love NR, Cheung C, McCalmont TH, Kim J

MicroRNA Ratios Distinguish Melanomas from Nevi.

The Journal of investigative dermatology

Torres R, Lang UE, Hejna M, Shelton SJ, Joseph NM, Shain AH, Yeh I, Wei ML, Oldham MC, Bastian BC, Judson-Torres RL

Depletion of primary cilium in acral melanoma.

Journal of cutaneous pathology

Love NR, Lang UE, Cheung C, Kim J

Suppression of Exosomal PD-L1 Induces Systemic Anti-tumor Immunity and Memory.

Cell

Poggio M, Hu T, Pai CC, Chu B, Belair CD, Chang A, Montabana E, Lang UE, Fu Q, Fong L, Blelloch R

Bi-allelic Loss of CDKN2A Initiates Melanoma Invasion via BRN2 Activation.

Cancer cell

Zeng H, Jorapur A, Shain AH, Lang UE, Torres R, Zhang Y, McNeal AS, Botton T, Lin J, Donne M, Bastian IN, Yu R, North JP, Pincus L, Ruben BS, Joseph NM, Yeh I, Bastian BC, Judson RL

Combined activation of MAP kinase pathway and ß-catenin signaling cause deep penetrating nevi.

Nature communications

Yeh I, Lang UE, Durieux E, Tee MK, Jorapur A, Shain AH, Haddad V, Pissaloux D, Chen X, Cerroni L, Judson RL, LeBoit PE, McCalmont TH, Bastian BC, de la Fouchardière A

Loss of primary cilia correlates with cytologic severity in dysplastic melanocytic nevi.

Journal of cutaneous pathology

Lang UE, Cheung C, Vladar EK, Swetter SM, Kim J

Post-transcriptional activation of PPAR alpha by KLF6 in hepatic steatosis.

Journal of hepatology

Bechmann LP, Vetter D, Ishida J, Hannivoort RA, Lang UE, Kocabayoglu P, Fiel MI, Muñoz U, Patman GL, Ge F, Yakar S, Li X, Agius L, Lee YM, Zhang W, Hui KY, Televantou D, Schwartz GJ, LeRoith D, Berk PD, Nagai R, Suzuki T, Reeves HL, Friedman SL

Reduced hepatic stellate cell expression of Kruppel-like factor 6 tumor suppressor isoforms amplifies fibrosis during acute and chronic rodent liver injury.

Hepatology (Baltimore, Md.)

Ghiassi-Nejad Z, Hernandez-Gea V, Woodrell C, Lang UE, Dumic K, Kwong A, Friedman SL

GSK3ß phosphorylation of the KLF6 tumor suppressor promotes its transactivation of p21.

Oncogene

Lang UE, Kocabayoglu P, Cheng GZ, Ghiassi-Nejad Z, Muñoz U, Vetter D, Eckstein DA, Hannivoort RA, Walsh MJ, Friedman SL

Vascular injury triggers Krüppel-like factor 6 mobilization and cooperation with specificity protein 1 to promote endothelial activation through upregulation of the activin receptor-like kinase 1 gene.

Circulation research

Garrido-Martín EM, Blanco FJ, Roquè M, Novensà L, Tarocchi M, Lang UE, Suzuki T, Friedman SL, Botella LM, Bernabéu C

Hepatocyte growth factor enhances alternative splicing of the Kruppel-like factor 6 (KLF6) tumor suppressor to promote growth through SRSF1.

Molecular cancer research : MCR

Muñoz Ú, Puche JE, Hannivoort R, Lang UE, Cohen-Naftaly M, Friedman SL

Glucokinase links Krüppel-like factor 6 to the regulation of hepatic insulin sensitivity in nonalcoholic fatty liver disease.

Hepatology (Baltimore, Md.)

Bechmann LP, Gastaldelli A, Vetter D, Patman GL, Pascoe L, Hannivoort RA, Lee UE, Fiel I, Muñoz U, Ciociaro D, Lee YM, Buzzigoli E, Miele L, Hui KY, Bugianesi E, Burt AD, Day CP, Mari A, Agius L, Walker M, Friedman SL, Reeves HL

Dendritic cell regulation of carbon tetrachloride-induced murine liver fibrosis regression.

Hepatology (Baltimore, Md.)

Jiao J, Sastre D, Fiel MI, Lee UE, Ghiassi-Nejad Z, Ginhoux F, Vivier E, Friedman SL, Merad M, Aloman C

A polymorphism that delays fibrosis in hepatitis C promotes alternative splicing of AZIN1, reducing fibrogenesis.

Hepatology (Baltimore, Md.)

Paris AJ, Snapir Z, Christopherson CD, Kwok SY, Lee UE, Ghiassi-Nejad Z, Kocabayoglu P, Sninsky JJ, Llovet JM, Kahana C, Friedman SL

Carcinogen-induced hepatic tumors in KLF6+/- mice recapitulate aggressive human hepatocellular carcinoma associated with p53 pathway deregulation.

Hepatology (Baltimore, Md.)

Tarocchi M, Hannivoort R, Hoshida Y, Lee UE, Vetter D, Narla G, Villanueva A, Oren M, Llovet JM, Friedman SL

Mechanisms of hepatic fibrogenesis.

Best practice & research. Clinical gastroenterology

Lee UE, Friedman SL

Characterization of the human Activin-A receptor type II-like kinase 1 (ACVRL1) promoter and its regulation by Sp1.

BMC molecular biology

Garrido-Martin EM, Blanco FJ, Fernandez-L A, Langa C, Vary CP, Lee UE, Friedman SL, Botella LM, Bernabeu C

Tumor suppressor activity of KLF6 mediated by downregulation of the PTTG1 oncogene.

FEBS letters

Lee UE, Ghiassi-Nejad Z, Paris AJ, Yea S, Narla G, Walsh M, Friedman SL