Renuka Nayak, MD, PhD

Assoc Professor in Residence

Dr. Renuka Nayak, MD, PhD, is a physician-scientist dedicated to advancing the care and treatment of patients with rheumatologic conditions such as rheumatoid arthritis, lupus, psoriatic arthritis, and other autoimmune diseases. She uses her unique backgrounds in Biology, Computer Science, and Clinical Rheumatology to investigate the role of the human gut microbiome in the treatment of rheumatoid arthritis. She uses an innovative combination of patient specimens, microbiology, next generation sequencing, and gnotobiotic mouse models to better understand how our microbiome, which many consider our "second genome," influences health and disease.

Publications:

Can we modulate the gut microbiome to enhance DMARD efficacy in rheumatoid arthritis?

Seminars in arthritis and rheumatism

Blank RB, Nayak RR, Scher JU

A diet-dependent host metabolite shapes the gut microbiota to protect from autoimmunity.

Cell reports

Alexander M, Upadhyay V, Rock R, Ramirez L, Trepka K, Puchalska P, Orellana D, Ang QY, Whitty C, Turnbaugh JA, Tian Y, Dumlao D, Nayak R, Patterson A, Newman JC, Crawford PA, Turnbaugh PJ

Microbiome research in autoimmune and immune-mediated inflammatory diseases: lessons, advances and unmet needs.

Annals of the rheumatic diseases

Scher JU, Nayak R, Clemente JC

The impact of the human gut microbiome on the treatment of autoimmune disease.

Immunological reviews

Nayak RR, Orellana DA

A diet-dependent host metabolite shapes the gut microbiota to protect from autoimmunity.

bioRxiv : the preprint server for biology

Alexander M, Upadhyay V, Rock R, Ramirez L, Puchalska P, Orellana D, Ang QY, Turnbaugh JA, Tian Y, Dumlao D, Nayak R, Patterson A, Newman JC, Crawford PA, Turnbaugh PJ

Alteration in the gut microbiome is associated with changes in bone metabolism after laparoscopic sleeve gastrectomy.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Wu KC, McCauley KE, Lynch SV, Nayak RR, King NJ, Patel S, Kim TY, Condra K, Fadrosh D, Nguyen D, Lin DL, Lynch K, Rogers SJ, Carter JT, Posselt AM, Stewart L, Schafer AL

Simvastatin induces human gut bacterial cell surface genes.

Molecular microbiology

Escalante V, Nayak RR, Noecker C, Babdor J, Spitzer M, Deutschbauer AM, Turnbaugh PJ

SIMMER employs similarity algorithms to accurately identify human gut microbiome species and enzymes capable of known chemical transformations.

eLife

Bustion AE, Nayak RR, Agrawal A, Turnbaugh PJ, Pollard KS

Genome-wide profiling identifies associations between lupus nephritis and differential methylation of genes regulating tissue hypoxia and type 1 interferon responses.

Lupus science & medicine

Mok A, Solomon O, Nayak RR, Coit P, Quach HL, Nititham J, Sawalha AH, Barcellos LF, Criswell LA, Chung SA

Renuka Nayak, MD, PhD

Can we modulate the gut microbiome to enhance DMARD efficacy in rheumatoid arthritis?

A diet-dependent host metabolite shapes the gut microbiota to protect from autoimmunity.

Microbiome research in autoimmune and immune-mediated inflammatory diseases: lessons, advances and unmet needs.

The impact of the human gut microbiome on the treatment of autoimmune disease.

A diet-dependent host metabolite shapes the gut microbiota to protect from autoimmunity.

Alteration in the gut microbiome is associated with changes in bone metabolism after laparoscopic sleeve gastrectomy.

Simvastatin induces human gut bacterial cell surface genes.

SIMMER employs similarity algorithms to accurately identify human gut microbiome species and enzymes capable of known chemical transformations.

Fanning the flames of autoimmunity: the microbiome in rheumatic disease.

Human gut bacterial metabolism drives Th17 activation and colitis.

Phage-delivered CRISPR-Cas9 for strain-specific depletion and genomic deletions in the gut microbiome.

Western Diet and Psoriatic-Like Skin and Joint Diseases: A Potential Role for the Gut Microbiota.

The Pretreatment Gut Microbiome Is Associated With Lack of Response to Methotrexate in New-Onset Rheumatoid Arthritis.

Methotrexate impacts conserved pathways in diverse human gut bacteria leading to decreased host immune activation.

Pharmacomicrobiomics in inflammatory arthritis: gut microbiome as modulator of therapeutic response.

Genome-wide profiling identifies associations between lupus nephritis and differential methylation of genes regulating tissue hypoxia and type 1 interferon responses.

Mirror, mirror on the wall: which microbiomes will help heal them all?

Stress-induced changes in gene interactions in human cells.

Polymorphic cis- and trans-regulation of human gene expression.

Gene expression and genetic variation in response to endoplasmic reticulum stress in human cells.

Coexpression network based on natural variation in human gene expression reveals gene interactions and functions.

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Renuka Nayak, MD, PhD