Maya Kotas, MD, PhD

Assistant Professor In Res

Dr. Kotas is an Assistant Professor in the Division of Pulmonary, Critical Care, Sleep, Allergy and Sleep Medicine. She received her BA, MD and PhD from Yale University. After completing residency training in Internal Medicine at New York Presbyterian - Columbia University, she completed a fellowship in Pulmonary & Critical Care Medicine at UCSF. She serves as an attending physician in the intensive care units at UCSF.

Dr. Kotas's research focuses on the role of the innate immune system in regulating the biology of the airway epithelium. Her work utilizes mouse modeling and patient samples to better understand how the immune system reshapes the cells that line the airway during allergic diseases. The goal of this work is to discover new targets for treatment of allergic airway diseases.


Group 2 innate lymphoid cells constrain type 3/17 lymphocytes in shared stromal niches to restrict liver fibrosis.

bioRxiv : the preprint server for biology

Sbierski-Kind J, Cautivo KM, Wagner JC, Dahlgren MW, Nilsson J, Krasilnikov M, Mroz NM, Lizama CO, Gan AL, Matatia PR, Taruselli MT, Chang AA, Caryotakis S, O'Leary CE, Kotas M, Mattis AN, Peng T, Locksley RM, Molofsky AB

Interleukin-13 associated epithelial remodeling correlates with clinical severity in nasal polyposis.

The Journal of allergy and clinical immunology

Kotas ME, Patel NN, Cope EK, Gurrola JG, Goldberg AN, Pletcher SD, Seibold MA, Moore CM, Gordon ED

Tuft Cells: Context- and Tissue-Specific Programming for a Conserved Cell Lineage.

Annual review of pathology

Kotas ME, O'Leary CE, Locksley RM

Injury-induced pulmonary tuft cells are heterogenous, arise independent of key Type 2 cytokines, and are dispensable for dysplastic repair.


Barr J, Gentile ME, Lee S, Kotas ME, Fernanda de Mello Costa M, Holcomb NP, Jaquish A, Palashikar G, Soewignjo M, McDaniel M, Matsumoto I, Margolskee R, Von Moltke J, Cohen NA, Sun X, Vaughan AE

Innate type 2 immunity controls hair follicle commensalism by Demodex mites.


Ricardo-Gonzalez RR, Kotas ME, O'Leary CE, Singh K, Damsky W, Liao C, Arouge E, Tenvooren I, Marquez DM, Schroeder AW, Cohen JN, Fassett MS, Lee J, Daniel SG, Bittinger K, Díaz RE, Fraser JS, Ali N, Ansel KM, Spitzer MH, Liang HE, Locksley RM

IL-13-programmed airway tuft cells produce PGE2, which promotes CFTR-dependent mucociliary function.

JCI insight

Kotas ME, Moore CM, Gurrola Ii JG, Pletcher SD, Goldberg AN, Alvarez R, Yamato S, Bratcher PE, Shaughnessy CA, Zeitlin PL, Zhang IH, Li Y, Montgomery MT, Lee K, Cope EK, Locksley RM, Seibold MA, Gordon ED

Innate type 2 immunity controls hair follicle commensalism by Demodex mites.

The Journal of Immunology

Roberto R Ricardo-Gonzalez, Maya E Kotas, Claire O’Leary, Iliana Tenvooren, Diana Marquez, Katelyn Singh, William Damsky, Chang Liao, Andrew Schroeder, Jarish Cohen, Marlys S Fassett, Jinwoo Lee, Scott G Daniel, Kyle Bittinger, Roberto Efrain Diaz, James Fraser, Karl Mark Ansel, Matthew Spitzer, Hong-Erh Liang, Richard M Locksley

Bile acid-sensitive tuft cells regulate biliary neutrophil influx.

Science immunology

O'Leary CE, Sbierski-Kind J, Kotas ME, Wagner JC, Liang HE, Schroeder AW, de Tenorio JC, von Moltke J, Ricardo-Gonzalez RR, Eckalbar WL, Molofsky AB, Schneider C, Locksley RM

CISH constrains the tuft-ILC2 circuit to set epithelial and immune tone.

Mucosal immunology

Kotas ME, Mroz NM, Koga S, Liang HE, Schroeder AW, Ricardo-Gonzalez RR, Schneider C, Locksley RM

A role for IL-33-activated ILC2s in eosinophilic vasculitis.

JCI insight

Kotas ME, Dion J, Van Dyken S, Ricardo-Gonzalez RR, Danel CJ, Taillé C, Mouthon L, Locksley RM, Terrier B

Why Innate Lymphoid Cells?


Kotas ME, Locksley RM

Mesenchymal stromal cells and macrophages in sepsis: new insights.

The European respiratory journal

Kotas ME, Matthay MA

Central serotonergic neurons activate and recruit thermogenic brown and beige fat and regulate glucose and lipid homeostasis.

Cell metabolism

McGlashon JM, Gorecki MC, Kozlowski AE, Thirnbeck CK, Markan KR, Leslie KL, Kotas ME, Potthoff MJ, Richerson GB, Gillum MP

cAMP-responsive element-binding protein (CREB)-regulated transcription coactivator 2 (CRTC2) promotes glucagon clearance and hepatic amino acid catabolism to regulate glucose homeostasis.

The Journal of biological chemistry

Erion DM, Kotas ME, McGlashon J, Yonemitsu S, Hsiao JJ, Nagai Y, Iwasaki T, Murray SF, Bhanot S, Cline GW, Samuel VT, Shulman GI, Gillum MP

Sirtuin-1 is a nutrient-dependent modulator of inflammation.


Kotas ME, Gorecki MC, Gillum MP

Role of caspase-1 in regulation of triglyceride metabolism.

Proceedings of the National Academy of Sciences of the United States of America

Kotas ME, Jurczak MJ, Annicelli C, Gillum MP, Cline GW, Shulman GI, Medzhitov R

SirT1 regulates adipose tissue inflammation.


Gillum MP, Kotas ME, Erion DM, Kursawe R, Chatterjee P, Nead KT, Muise ES, Hsiao JJ, Frederick DW, Yonemitsu S, Banks AS, Qiang L, Bhanot S, Olefsky JM, Sears DD, Caprio S, Shulman GI

Impact of CD1d deficiency on metabolism.

PloS one

Kotas ME, Lee HY, Gillum MP, Annicelli C, Guigni BA, Shulman GI, Medzhitov R

Comparative Evaluation of Methods Used for Sampling Malaria Vectors in the Kilombero Valley, South Eastern Tanzania.

The Open Tropical Medicine Journal

Fredros O. Okumu, Maya E. Kotas, Japheth Kihonda, Evan Mathenge, Gerry F. Killeen, Sarah J. Moore

Replacement of bone marrow by bone in rat femurs: the bone bioreactor.

Tissue engineering. Part A

Zhang Q, Cuartas E, Mehta N, Gilligan J, Ke HZ, Saltzman WM, Kotas M, Ma M, Rajan S, Chalouni C, Carlson J, Vignery A

Replacement of Bone Marrow by Bone in Rat Femurs: The Bone Bioreactor.

Tissue Engineering

Qing Zhang, Esteban Cuartas, Nozer Mehta, James Gilligan, Hua-Zhu Ke, W. Mark Saltzman, Maya Kotas, Mandy Ma, Sonali Rajan, Cécile Chalouni, Jodi Carlson, Agnès Vignery

Cost-sharing strategies combining targeted public subsidies with private-sector delivery achieve high bednet coverage and reduced malaria transmission in Kilombero Valley, southern Tanzania.

BMC infectious diseases

Killeen GF, Tami A, Kihonda J, Okumu FO, Kotas ME, Grundmann H, Kasigudi N, Ngonyani H, Mayagaya V, Nathan R, Abdulla S, Charlwood JD, Smith TA, Lengeler C

Quantifying behavioural interactions between humans and mosquitoes: evaluating the protective efficacy of insecticidal nets against malaria transmission in rural Tanzania.

BMC infectious diseases

Killeen GF, Kihonda J, Lyimo E, Oketch FR, Kotas ME, Mathenge E, Schellenberg JA, Lengeler C, Smith TA, Drakeley CJ