Matilda Chan, MD, PhD

Professor in Residence
Ophthalmology
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Matilda Chan is a cornea specialist at the F.I. Proctor Foundation. Her clinical expertise is the diagnosis and management of patients with corneal and ocular surface diseases. Her basic and translational research program focuses on understanding the cellular and molecular responses to corneal injury.

Publications: 

Peer Review in Ophthalmology: A Collaborative Approach to Training the Next Generation of Reviewers.

Investigative ophthalmology & visual science

Chan MF, Council of Vision Editors

Calcium-sensing receptor (CaSR) modulates ocular surface chloride transport and its inhibition promotes ocular surface hydration.

The ocular surface

Pasricha ND, Lindgren ES, Yan R, Kuo YM, Chan M, Verkman AS, Chu T, Yottasan P, de Souza Goncalves L, Cil O

Incidence and Mitigation of Corneal Pseudomicrocysts Induced by Antibody-Drug Conjugates (ADCs).

Current ophthalmology reports

Lindgren ES, Yan R, Cil O, Verkman AS, Chan MF, Seitzman GD, Farooq AV, Huppert LA, Rugo HS, Pohlmann PR, Lu J, Esserman LJ, Pasricha ND

Isolated Ocular Mpox without Skin Lesions, United States.

Emerging infectious diseases

Nguyen MT, Mentreddy A, Schallhorn J, Chan M, Aung S, Doernberg SB, Babik J, Miles K, Yang K, Lydon E, Minter DJ, Gonzales J, Shantha J, Doan T, Seitzman GD

Disrupting autorepression circuitry generates ''open-loop lethality'' to yield escape-resistant antiviral agents.

Cell

Chaturvedi S, Pablo M, Wolf M, Rosas-Rivera D, Calia G, Kumar AJ, Vardi N, Du K, Glazier J, Ke R, Chan MF, Perelson AS, Weinberger LS

Characterization of Infectious Keratitis in Opioid Users in a County Hospital Setting.

Cornea open

Lopez JB, Chan L, Saifee M, Seitzman GD, Yung M, Chan MF

Oxytocin and secretin receptors - implications for dry eye syndrome and ocular pain.

Frontiers in ophthalmology

Lopez JB, Chang CC, Kuo YM, Chan MF, Winn BJ

Disrupting autorepression circuitry generates "open-loop lethality" to yield escape-resistant antiviral agents.

Cell

Chaturvedi S, Pablo M, Wolf M, Rosas-Rivera D, Calia G, Kumar AJ, Vardi N, Du K, Glazier J, Ke R, Chan MF, Perelson AS, Weinberger LS

Characterization of Recruited Mononuclear Phagocytes following Corneal Chemical Injury.

International journal of molecular sciences

Lamy R, Wolf M, Bispo C, Clay SM, Zheng S, Wolfreys F, Pan P, Chan MF

Spontaneous hyphema in the setting of COVID-19 pneumonia.

American journal of ophthalmology case reports

Chiang J, Chan L, Stallworth JY, Chan MF

Pulsating Cilioretinal Artery From Ocular Hypertension.

JAMA ophthalmology

Liu Y, Chan MF, Stewart JM

Corneal Repair Models in Mice: Epithelial/Mechanical Versus Stromal/Chemical Injuries.

Methods in molecular biology (Clifton, N.J.)

Pan P, Chan MF

Author Correction: Aberrant DNA methylation of miRNAs in Fuchs endothelial corneal dystrophy.

Scientific reports

Pan P, Weisenberger DJ, Zheng S, Wolf M, Hwang DG, Rose-Nussbaumer JR, Jurkunas UV, Chan MF

Aberrant DNA methylation of miRNAs in Fuchs endothelial corneal dystrophy.

Scientific reports

Pan P, Weisenberger DJ, Zheng S, Wolf M, Hwang DG, Rose-Nussbaumer JR, Jurkunas UV, Chan MF

MMP12 Inhibits Corneal Neovascularization and Inflammation through Regulation of CCL2.

Scientific reports

Wolf M, Clay SM, Zheng S, Pan P, Chan MF

Overexpression of MMPs in Corneas Requiring Penetrating and Deep Anterior Lamellar Keratoplasty.

Investigative ophthalmology & visual science

Wolf M, Clay SM, Oldenburg CE, Rose-Nussbaumer J, Hwang DG, Chan MF

Epidemiology of uveitis in a US population-based study.

Journal of ophthalmic inflammation and infection

González MM, Solano MM, Porco TC, Oldenburg CE, Acharya NR, Lin SC, Chan MF

Effects of MMP12 on cell motility and inflammation during corneal epithelial repair.

Experimental eye research

Wolf M, Maltseva I, Clay SM, Pan P, Gajjala A, Chan MF

Comprehensive characterization of DNA methylation changes in Fuchs endothelial corneal dystrophy.

PloS one

Khuc E, Bainer R, Wolf M, Clay SM, Weisenberger DJ, Kemmer J, Weaver VM, Hwang DG, Chan MF

sFlt Multivalent Conjugates Inhibit Angiogenesis and Improve Half-Life In Vivo.

PloS one

Altiok EI, Browne S, Khuc E, Moran EP, Qiu F, Zhou K, Santiago-Ortiz JL, Ma JX, Chan MF, Healy KE

Metalloproteinases: a Functional Pathway for Myeloid Cells.

Microbiology spectrum

Chou J, Chan MF, Werb Z

Animal Models of Corneal Injury.

Bio-protocol

Chan MF, Werb Z

Protective effects of matrix metalloproteinase-12 following corneal injury.

Journal of cell science

Chan MF, Li J, Bertrand A, Casbon AJ, Lin JH, Maltseva I, Werb Z

The clinical differentiation of bacterial and fungal keratitis: a photographic survey.

Investigative ophthalmology & visual science

Dalmon C, Porco TC, Lietman TM, Prajna NV, Prajna L, Das MR, Kumar JA, Mascarenhas J, Margolis TP, Whitcher JP, Jeng BH, Keenan JD, Chan MF, McLeod SD, Acharya NR

Membrane array analysis of tear proteins in ocular cicatricial pemphigoid.

Optometry and vision science : official publication of the American Academy of Optometry

Chan MF, Sack R, Quigley DA, Sathe S, Vijmasi T, Li S, Holsclaw D, Strauss EC, McNamara NA

Microbiological cure times in acanthamoeba keratitis.

Eye (London, England)

Oldenburg CE, Keenan JD, Cevallos V, Chan MF, Acharya NR, Gaynor BD, McLeod SD, Esterberg EJ, Porco TC, Lietman TM

Late varicella-zoster virus dendriform keratitis in patients with histories of herpes zoster ophthalmicus.

American journal of ophthalmology

Hu AY, Strauss EC, Holland GN, Chan MF, Yu F, Margolis TP

Cicatrising conjunctivitis due to paraneoplastic pemphigoid.

The British journal of ophthalmology

Rutar T, Chan MF, Acharya NR, Naseri A

Interleukin-6 protects retinal ganglion cells from pressure-induced death.

Investigative ophthalmology & visual science

Sappington RM, Chan M, Calkins DJ

Cooperativity between DNA methyltransferases in the maintenance methylation of repetitive elements.

Molecular and cellular biology

Liang G, Chan MF, Tomigahara Y, Tsai YC, Gonzales FA, Li E, Laird PW, Jones PA

Reduced rates of gene loss, gene silencing, and gene mutation in Dnmt1-deficient embryonic stem cells.

Molecular and cellular biology

Chan MF, van Amerongen R, Nijjar T, Cuppen E, Jones PA, Laird PW

Relationship between transcription and DNA methylation.

Current topics in microbiology and immunology

Chan MF, Liang G, Jones PA

Evidence for two tumor suppressor loci associated with proximal chromosome 9p to q and distal chromosome 9q in bladder cancer and the initial screening for GAS1 and PTC mutations.

Cancer research

Simoneau AR, Spruck CH, Gonzalez-Zulueta M, Gonzalgo ML, Chan MF, Tsai YC, Dean M, Steven K, Horn T, Jones PA