Lin Shen, MD, PhD

Alumni (Medicine-Rheum)
now at UChicago

Autoimmune rheumatic diseases, which constitute a broad range of chronic illnesses, cause significant morbidity and mortality in the US and worldwide. T cell receptor (TCR) recognition and signaling have long be recognized to play a critical role in the pathogenesis of autoimmune diseases. However, how altered TCR signaling strength affects immune tolerance and promotes autoimmunity remains incompletely understood. Dr. Shen’s research seeks to understand how abnormal TCR signaling resulting from mutations from human patients with complex autoimmune syndrome may alter T cell antigen sensitivity, affect T helper cell fate, and impair immune tolerance. Studying human monogenic diseases with known genetic defects and autoimmune phenotypes provides us with a unique opportunity for advancing our knowledge of disease pathogenesis of more common polygenic autoimmune diseases. These studies may also have implications in preventing cancer immunotherapy related adverse events and identification of new therapeutic targets for autoimmune diseases.


ZAP70, too little, too much can lead to autoimmunity.

Immunological reviews

Ashouri JF, Lo WL, Nguyen TTT, Shen L, Weiss A

Cbl-b deficiency prevents functional but not phenotypic T cell anergy.

The Journal of experimental medicine

Nguyen TTT, Wang ZE, Shen L, Schroeder A, Eckalbar W, Weiss A

ZAP-70 in Signaling, Biology, and Disease.

Annual review of immunology

Au-Yeung BB, Shah NH, Shen L, Weiss A

A quantitative basis for antiretroviral therapy for HIV-1 infection.

Nature medicine

Jilek BL, Zarr M, Sampah ME, Rabi SA, Bullen CK, Lai J, Shen L, Siliciano RF

A critical subset model provides a conceptual basis for the high antiviral activity of major HIV drugs.

Science translational medicine

Shen L, Rabi SA, Sedaghat AR, Shan L, Lai J, Xing S, Siliciano RF

Dose-response curve slope is a missing dimension in the analysis of HIV-1 drug resistance.

Proceedings of the National Academy of Sciences of the United States of America

Sampah ME, Shen L, Jilek BL, Siliciano RF

Consistent inhibition of HIV-1 replication in CD4+ T cells by acyclovir without detection of human herpesviruses.

Journal of virology

McMahon MA, Parsons TL, Shen L, Siliciano JD, Siliciano RF

Discovery of entry inhibitors for HIV-1 via a new de novo protein design framework.

Biophysical journal

Bellows ML, Taylor MS, Cole PA, Shen L, Siliciano RF, Fung HK, Floudas CA

Unstimulated primary CD4+ T cells from HIV-1-positive elite suppressors are fully susceptible to HIV-1 entry and productive infection.

Journal of virology

Rabi SA, O'Connell KA, Nikolaeva D, Bailey JR, Jilek BL, Shen L, Page KR, Siliciano RF, Blankson JN

Achieving a quantitative understanding of antiretroviral drug efficacy.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Shen L, Siliciano RF

A novel method for determining the inhibitory potential of anti-HIV drugs.

Trends in pharmacological sciences

Shen L, Rabi SA, Siliciano RF

New approaches for quantitating the inhibition of HIV-1 replication by antiviral drugs in vitro and in vivo.

Current opinion in infectious diseases

McMahon MA, Shen L, Siliciano RF

Isolation of a cellular factor that can reactivate latent HIV-1 without T cell activation.

Proceedings of the National Academy of Sciences of the United States of America

Yang HC, Shen L, Siliciano RF, Pomerantz JL

Dose-response curve slope sets class-specific limits on inhibitory potential of anti-HIV drugs.

Nature medicine

Shen L, Peterson S, Sedaghat AR, McMahon MA, Callender M, Zhang H, Zhou Y, Pitt E, Anderson KS, Acosta EP, Siliciano RF

Decay dynamics of HIV-1 depend on the inhibited stages of the viral life cycle.

Proceedings of the National Academy of Sciences of the United States of America

Sedaghat AR, Dinoso JB, Shen L, Wilke CO, Siliciano RF

The HBV drug entecavir - effects on HIV-1 replication and resistance.

The New England journal of medicine

McMahon MA, Jilek BL, Brennan TP, Shen L, Zhou Y, Wind-Rotolo M, Xing S, Bhat S, Hale B, Hegarty R, Chong CR, Liu JO, Siliciano RF, Thio CL