Julie Saba, MD, PhD

Professor In Residence
Pediatrics

physician-scientist
(she/her/hers)

Sphingosine-1-phosphate (S1P) is a bioactive lipid that plays important roles in development, vascular biology, immune cell trafficking, carcinogenesis and other physiological processes. S1P mediates its actions primarily by signaling through a family of G protein-coupled receptors. Our research group is investigating the role of S1P metabolism and signaling in development and disease using cellular and animal models, translational approaches and metabolomics profiling. Our recent findings demonstrate that defects in S1P metabolism underlie a novel childhood syndrome called sphingosine phosphate lyase insufficiency syndrome (SPLIS), which is characterized by defects of kidney, adrenal gland, neurological system, skin and immune system. We are now developing several therapeutic approaches to the treatment of SPLIS including gene therapy and cofactor supplementation.

Publications: 

AF1q is a universal marker of neuroblastoma that sustains N-Myc expression and drives tumorigenesis.

Oncogene

Oskouian B, Lee JY, Asgharzadeh S, Khan R, Zhang M, Weisbrod JR, Choi YJ, Puri L, Aguilar AE, Zhao P, Saba JD

Gene therapy with AAV9-SGPL1 in an animal model of lung fibrosis.

The Journal of pathology

Bhattacharyya A, Khan R, Lee JY, Tassew G, Oskouian B, Allende ML, Proia RL, Yin X, Ortega JG, Bhattacharya M, Saba JD

Prevalence estimate of sphingosine phosphate lyase insufficiency syndrome in worldwide and select populations.

Genetics in Medicine Open

Joni C. Sedillo, Chansonette Badduke, Steven J. Schrodi, Vinod Scaria, Onur Emre Onat, Majid Alfadhel, Carole Ober, William Wentworth-Sheilds, Robert D. Steiner, Julie D. Saba

AAV-SPL 2.0, a Modified Adeno-Associated Virus Gene Therapy Agent for the Treatment of Sphingosine Phosphate Lyase Insufficiency Syndrome.

International journal of molecular sciences

Khan R, Oskouian B, Lee JY, Hodgin JB, Yang Y, Tassew G, Saba JD

148 Exploring dual targeting of host and microbial sphingosine-1-phosphate lyase as antimicrobial strategy in cystic fibrosis.

Journal of Cystic Fibrosis

C. Costantini, G. Pampalone, M. Pariano, T. Zelante, L. Macchioni, R. Galarini, E. Camaioni, F. Paoletti, F. Catalano, M. Davidescu, C. Stincardini, M. Bellet, J. Saba, G. Giardina, S. Giovagnoli, B. Cellini, L. Romani

Sphingosine phosphate lyase insufficiency syndrome: a systematic review.

World journal of pediatrics : WJP

Pournasiri Z, Madani A, Nazarpack F, Sayer JA, Chavoshzadeh Z, Nili F, Tran P, Saba JD, Jamee M

Neurological Consequences of Sphingosine Phosphate Lyase Insufficiency.

Frontiers in cellular neuroscience

Atreya KB, Saba JD

Sphingosine Phosphate Lyase Is Upregulated in Duchenne Muscular Dystrophy, and Its Inhibition Early in Life Attenuates Inflammation and Dystrophy in Mdx Mice.

International journal of molecular sciences

De la Garza-Rodea AS, Moore SA, Zamora-Pineda J, Hoffman EP, Mistry K, Kumar A, Strober JB, Zhao P, Suh JH, Saba JD

521: Dual targeting of host and fungal sphingosine-1-phosphate lyase as antifungal strategy in cystic fibrosis.

Journal of Cystic Fibrosis

C. Costantini, M. Pariano, G. Pampalone, T. Zelante, L. Macchioni, R. Galarini, E. Costanzi, M. Bellet, S. Giovagnoli, J. Saba, B. Cellini, L. Romani

Mouse Liver Compensates Loss of Sgpl1 by Secretion of Sphingolipids into Blood and Bile.

International journal of molecular sciences

Spohner AK, Jakobi K, Trautmann S, Thomas D, Schumacher F, Kleuser B, Lütjohann D, El-Hindi K, Grösch S, Pfeilschifter J, Saba JD, Meyer Zu Heringdorf D

Genotype/Phenotype Interactions and First Steps Toward Targeted Therapy for Sphingosine Phosphate Lyase Insufficiency Syndrome.

Cell biochemistry and biophysics

Saba JD, Keller N, Wang JY, Tang F, Slavin A, Shen Y

Efficacy of AAV9-mediated SGPL1 gene transfer in a mouse model of S1P lyase insufficiency syndrome.

JCI insight

Zhao P, Tassew GB, Lee JY, Oskouian B, Muñoz DP, Hodgin JB, Watson GL, Tang F, Wang JY, Luo J, Yang Y, King S, Krauss RM, Keller N, Saba JD

MRI Spectrum of Brain Involvement in Sphingosine-1-Phosphate Lyase Insufficiency Syndrome.

AJNR. American journal of neuroradiology

Martin KW, Weaver N, Alhasan K, Gumus E, Sullivan BR, Zenker M, Hildebrandt F, Saba JD

Responsiveness of sphingosine phosphate lyase insufficiency syndrome to vitamin B6 cofactor supplementation.

Journal of inherited metabolic disease

Zhao P, Liu ID, Hodgin JB, Benke PI, Selva J, Torta F, Wenk MR, Endrizzi JA, West O, Ou W, Tang E, Goh DL, Tay SK, Yap HK, Loh A, Weaver N, Sullivan B, Larson A, Cooper MA, Alhasan K, Alangari AA, Salim S, Gumus E, Chen K, Zenker M, Hildebrandt F, Saba JD

Correction to: Sphingadienes show therapeutic efficacy in neuroblastoma in vitro and in vivo by targeting the AKT signaling pathway.

Investigational new drugs

Zhao P, Aguilar AE, Lee JY, Paul LA, Suh JH, Puri L, Zhang M, Beckstead J, Witkowski A, Ryan RO, Saba JD

Unraveling the ß-amyloid clearance by astrocytes: Involvement of metabotropic glutamate receptor 3, sAPPa, and class-A scavenger receptor.

Neurochemistry international

Durand D, Turati J, Rudi MJ, Ramírez D, Saba J, Caruso C, Carniglia L, von Bernhardi R, Lasaga M

Sphingosine 1-phosphate lyase promotes the type I interferon-mediated innate immune response to influenza but is subjected to degradation by influenza A virus NS1.

The Journal of Immunology

Jennifer J Wolf, Chuan Xia, Madhuvanthi Vijayan, Yuleum Song, Caleb J Studstill, Hanh Ngo, Marc C Johnson, Julie D Saba, Stephen Alexander, Bumsuk Hahm

Astrocyte truncated tropomyosin receptor kinase B mediates brain-derived neurotrophic factor anti-apoptotic effect leading to neuroprotection.

Journal of neurochemistry

Saba J, Turati J, Ramírez D, Carniglia L, Durand D, Lasaga M, Caruso C

Sphingosine-1-Phosphate Signaling and Metabolism Gene Signature in Pediatric Inflammatory Bowel Disease: A Matched-case Control Pilot Study.

Inflammatory bowel diseases

Suh JH, Degagné É, Gleghorn EE, Setty M, Rodriguez A, Park KT, Verstraete SG, Heyman MB, Patel AS, Irek M, Gildengorin GL, Hubbard NE, Borowsky AD, Saba JD

Sphingadienes show therapeutic efficacy in neuroblastoma in vitro and in vivo by targeting the AKT signaling pathway.

Investigational new drugs

Zhao P, Aguilar AE, Lee JY, Paul LA, Suh JH, Puri L, Zhang M, Beckstead J, Witkowski A, Ryan RO, Saba JD

S100 Calcium Binding Protein A6.

Brian R. Dempsey, Anne C. Rintala-Dempsey, Gary S. Shaw, Igor Prudovsky, Thallapuranam Krishnaswamy Suresh Kumar, Rosario Donato, Rosario Donato, Guglielmo Sorci, Ileana Giambanco, Isadora Carolina Betim Pavan, Fernando Riback Silva, Ana Paula Morelli, Fernando Moreira Simabuco, Yuan Xiao Zhu, A. Keith Stewart, Jaime O. Claudio, Constance E. Runyan, H. William Schnaper, Sushant Singh, Sanjaya K. Sahoo, Muthu Periasamy, Erno Zádor, Magdolna Kósa, Chiung-Ya Chen, Yi-Ping Hsueh, Herman E. Popeijus, Alice Guyon, Laurence J. Miller, Sari S. Hannila, Manoj B. Menon, Akio Yamashita, Veerle Janssens, Ralf-Peter Czekay, Tessa M. Simone, Paul J. Higgins, David Della-Morte, Donatella Pastore, Barbara Capuani, Francesca Pacifici, Davide Lauro, Béatrice L. Charreau, Philip D. King, Matthew D. Blunt, Stephen G. Ward, Christophe Erneux, Stéphane Schurmans, Colin G. Rousseaux, Yasuyuki Saito, Yoji Murata, Takenori Kotani, Takashi Matozaki, Pedro Gomes, Xiaogang Chu, Ryan George, Raghavan Raju, Annegret Reinhold, Burkhart L. Schraven, Víctor Sorribas, Ali H. Jalloul, Robert T. Szerencsei, Tatiana P. Rogasevskaia, Paul P. M. Schnetkamp, Sylvia Y. M. Yao, James D. Young, Bruno Gasnier, Ian Forster, Andreas Werner, Laura R. de La Ballina, Tomás de Garay, Chloé C. Féral, Manuel Palacín, Meytal Landau, Mitsunori Fukuda, Jong Ran Lee, Salman Tamaddon-Jahromi, Venkateswarlu Kanamarlapudi, Julia Strebovsky, Jana Zimmer, Alexander H. Dalpke, Barbara Mariniello, Kaitlyn Ryan, Chin Chiang, Gianni Colotti, Andrea Ilari, Koji Shimozaki, Shiro Koizume, Yohei Miyagi, Aleksander Czogalla, Nadine Beckmann, Erich Gulbins, Katrin Anne Becker, Alexander Carpinteiro, Heidi Neubauer, Stuart Pitson, Ashok Kumar, Julie D. Saba, Samar Masoumi-Moghaddam, Afshin Amini, Sausan A. Moharram, Lars Rönnstrand, Julhash U. Kazi, Sausan A. Moharram, Lars Rönnstrand, Julhash U. Kazi, David A. Jans, Gurpreet Kaur, Cecilia Poderoso, Ana F. Castillo, Pablo G. Mele, Paula M. Maloberti, Ernesto J. Podestá, Su Jun Lim, Willis X. Li, Benjamin Skalkoyannis, Venkateswarlu Kanamarlapudi, Marc J. Tetel, Pui Man Rosalind Lai, Pradeep Kurup, Jian Xu, Manavi Chatterjee, Susan Goebel-Goody, Surojit Paul, Paul Lombroso, Wesley H. Brooks, Sreya Mukherjee, Malgorzata Kloc, Jacek Z. Kubiak, Pia Ragno, Jie Zhang, Zhi-wei Ye, Robert R. Bowers, Danyelle M. Townsend, Kenneth D. Tew, Mikko O. Laukkanen, Alessia Parascandolo, Niharika Swain, Rashmi Maruti Hosalkar, Payel Sen, Nilanjana Chatterjee, Blaine Bartholomew, Robert L. Geahlen, Ashley Bernardo, Shreya Prashar, Luke Molinaro, Ram Mishra, Sang-Ho Song, George J. Augustine, Niharika Swain, Rashmi Maruti Hosalkar, Samapika Routray, Valérie Drouet, Suzanne Lesage, Alexis Brice, Arie Horowitz

Sphingosine-1-Phosphate.

Encyclopedia of Signaling Molecules

Ashok Kumar, Julie D. Saba

S1P Lyase Regulation of Thymic Egress and Oncogenic Inflammatory Signaling.

Mediators of inflammation

Kumar A, Zamora-Pineda J, Degagné E, Saba JD

Overexpression of sphingosine-1-phosphate lyase protects insulin-secreting cells against cytokine toxicity.

The Journal of biological chemistry

Hahn C, Tyka K, Saba JD, Lenzen S, Gurgul-Convey E

An LC/MS/MS method for quantitation of chemopreventive sphingadienes in food products and biological samples.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

Suh JH, Makarova AM, Gomez JM, Paul LA, Saba JD

SGPL1 (sphingosine phosphate lyase 1) modulates neuronal autophagy via phosphatidylethanolamine production.

Autophagy

Mitroi DN, Karunakaran I, Gräler M, Saba JD, Ehninger D, Ledesma MD, van Echten-Deckert G

Mutations in sphingosine-1-phosphate lyase cause nephrosis with ichthyosis and adrenal insufficiency.

The Journal of clinical investigation

Lovric S, Goncalves S, Gee HY, Oskouian B, Srinivas H, Choi WI, Shril S, Ashraf S, Tan W, Rao J, Airik M, Schapiro D, Braun DA, Sadowski CE, Widmeier E, Jobst-Schwan T, Schmidt JM, Girik V, Capitani G, Suh JH, Lachaussée N, Arrondel C, Patat J, Gribouval O, Furlano M, Boyer O, Schmitt A, Vuiblet V, Hashmi S, Wilcken R, Bernier FP, Innes AM, Parboosingh JS, Lamont RE, Midgley JP, Wright N, Majewski J, Zenker M, Schaefer F, Kuss N, Greil J, Giese T, Schwarz K, Catheline V, Schanze D, Franke I, Sznajer Y, Truant AS, Adams B, Désir J, Biemann R, Pei Y, Ars E, Lloberas N, Madrid A, Dharnidharka VR, Connolly AM, Willing MC, Cooper MA, Lifton RP, Simons M, Riezman H, Antignac C, Saba JD, Hildebrandt F

Neuropeptides and Microglial Activation in Inflammation, Pain, and Neurodegenerative Diseases.

Mediators of inflammation

Carniglia L, Ramírez D, Durand D, Saba J, Turati J, Caruso C, Scimonelli TN, Lasaga M

Sphingosine 1-phosphate lyase ablation disrupts presynaptic architecture and function via an ubiquitin- proteasome mediated mechanism.

Scientific reports

Mitroi DN, Deutschmann AU, Raucamp M, Karunakaran I, Glebov K, Hans M, Walter J, Saba J, Gräler M, Ehninger D, Sopova E, Shupliakov O, Swandulla D, van Echten-Deckert G

Dendritic cell sphingosine-1-phosphate lyase regulates thymic egress.

The Journal of experimental medicine

Zamora-Pineda J, Kumar A, Suh JH, Zhang M, Saba JD

Sphingosine-1-Phosphate.

Encyclopedia of Signaling Molecules

Ashok Kumar, Julie D. Saba

Regulation of Immune Cell Migration by Sphingosine-1-Phosphate.

Cellular and molecular biology (OMICS)

Kumar A, Saba JD

A facile stable-isotope dilution method for determination of sphingosine phosphate lyase activity.

Chemistry and physics of lipids

Suh JH, Eltanawy A, Rangan A, Saba JD

Sphingosine-1-phosphate lyase downregulation promotes colon carcinogenesis through STAT3-activated microRNAs.

The Journal of clinical investigation

Degagné E, Pandurangan A, Bandhuvula P, Kumar A, Eltanawy A, Zhang M, Yoshinaga Y, Nefedov M, de Jong PJ, Fong LG, Young SG, Bittman R, Ahmedi Y, Saba JD

Tracking hippo in the cancer jungle.

Chemistry & biology

Suh JH, Saba JD

Sphingosine phosphate lyase regulates myogenic differentiation via S1P receptor-mediated effects on myogenic microRNA expression.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

de la Garza-Rodea AS, Baldwin DM, Oskouian B, Place RF, Bandhuvula P, Kumar A, Saba JD

A novel role of a lipid species, sphingosine-1-phosphate, in epithelial innate immunity.

Molecular and cellular biology

Park K, Elias PM, Shin KO, Lee YM, Hupe M, Borkowski AW, Gallo RL, Saba J, Holleran WM, Uchida Y

Sphingosine-1-phosphate lyase expression in embryonic and adult murine tissues.

Journal of lipid research

Borowsky AD, Bandhuvula P, Kumar A, Yoshinaga Y, Nefedov M, Fong LG, Zhang M, Baridon B, Dillard L, de Jong P, Young SG, West DB, Saba JD

The sphingolipid degradation product trans-2-hexadecenal forms adducts with DNA.

Biochemical and biophysical research communications

Upadhyaya P, Kumar A, Byun HS, Bittman R, Saba JD, Hecht SS

Sphingosine-1-phosphate enhances satellite cell activation in dystrophic muscles through a S1PR2/STAT3 signaling pathway.

PloS one

Loh KC, Leong WI, Carlson ME, Oskouian B, Kumar A, Fyrst H, Zhang M, Proia RL, Hoffman EP, Saba JD

Chemopreventive sphingadienes downregulate Wnt signaling via a PP2A/Akt/GSK3ß pathway in colon cancer.

Carcinogenesis

Kumar A, Pandurangan AK, Lu F, Fyrst H, Zhang M, Byun HS, Bittman R, Saba JD

S100 Calcium-Binding Protein.

Brian R. Dempsey, Anne C. Rintala-Dempsey, Gary S. Shaw, Yuan Xiao Zhu, A. Keith Stewart, Jaime O. Claudio, Constance E. Runyan, H. William Schnaper, Philip D. King, Matthew D. Blunt, Stephen G. Ward, Annegret Reinhold, Burkhart L. Schraven, Mitsunori Fukuda, Jong Ran Lee, Julia Strebovsky, Alexander H. Dalpke, Barbara Mariniello, Kaitlyn Ryan, Chin Chiang, Ashok Kumar, Julie D. Saba, David A. Jans, Gurpreet Kaur, Marc J. Tetel, Pui Man Rosalind Lai, Pradeep Kurup, Jian Xu, Susan Goebel-Goody, Surojit Paul, Paul Lombroso, Pia Ragno, Robert R. Bowers, Danyelle M. Townsend, Kenneth D. Tew, Payel Sen, Nilanjana Chatterjee, Blaine Bartholomew, Arie Horowitz

Sphingosine-1-Phosphate.

Encyclopedia of Signaling Molecules

Brian R. Dempsey, Anne C. Rintala-Dempsey, Gary S. Shaw, Yuan Xiao Zhu, A. Keith Stewart, Jaime O. Claudio, Constance E. Runyan, H. William Schnaper, Philip D. King, Matthew D. Blunt, Stephen G. Ward, Annegret Reinhold, Burkhart L. Schraven, Mitsunori Fukuda, Jong Ran Lee, Julia Strebovsky, Alexander H. Dalpke, Barbara Mariniello, Kaitlyn Ryan, Chin Chiang, Ashok Kumar, Julie D. Saba, David A. Jans, Gurpreet Kaur, Marc J. Tetel, Pui Man Rosalind Lai, Pradeep Kurup, Jian Xu, Susan Goebel-Goody, Surojit Paul, Paul Lombroso, Pia Ragno, Robert R. Bowers, Danyelle M. Townsend, Kenneth D. Tew, Payel Sen, Nilanjana Chatterjee, Blaine Bartholomew, Arie Horowitz

Truth and consequences of sphingosine-1-phosphate lyase.

Advances in biological regulation

Aguilar A, Saba JD

Sphingolipid signaling and hematopoietic malignancies: to the rheostat and beyond.

Anti-cancer agents in medicinal chemistry

Loh KC, Baldwin D, Saba JD

A monoclonal antibody to O-acetyl-GD2 ganglioside and not to GD2 shows potent anti-tumor activity without peripheral nervous system cross-reactivity.

PloS one

Alvarez-Rueda N, Desselle A, Cochonneau D, Chaumette T, Clemenceau B, Leprieur S, Bougras G, Supiot S, Mussini JM, Barbet J, Saba J, Paris F, Aubry J, Birklé S

S1P lyase regulates DNA damage responses in vitro and in vivo.

The FASEB Journal

Julie Deane Saba, Ashok Kumar, Babak Oskouian, Henrik Fyrst, Meng Zhang

S1P lyase: a novel therapeutic target for ischemia-reperfusion injury of the heart.

American journal of physiology. Heart and circulatory physiology

Bandhuvula P, Honbo N, Wang GY, Jin ZQ, Fyrst H, Zhang M, Borowsky AD, Dillard L, Karliner JS, Saba JD

S1P lyase regulates DNA damage responses through a novel sphingolipid feedback mechanism.

Cell death & disease

Kumar A, Oskouian B, Fyrst H, Zhang M, Paris F, Saba JD

Sphingosine-1-phosphate lyase deficiency produces a pro-inflammatory response while impairing neutrophil trafficking.

The Journal of biological chemistry

Allende ML, Bektas M, Lee BG, Bonifacino E, Kang J, Tuymetova G, Chen W, Saba JD, Proia RL

Protection of LPS-induced murine acute lung injury by sphingosine-1-phosphate lyase suppression.

American journal of respiratory cell and molecular biology

Zhao Y, Gorshkova IA, Berdyshev E, He D, Fu P, Ma W, Su Y, Usatyuk PV, Pendyala S, Oskouian B, Saba JD, Garcia JG, Natarajan V

Synopsis of partial-body radiation diagnostic biomarkers and medical management of radiation injury workshop.

Radiation research

Prasanna PG, Blakely WF, Bertho JM, Chute JP, Cohen EP, Goans RE, Grace MB, Lillis-Hearne PK, Lloyd DC, Lutgens LC, Meineke V, Ossetrova NI, Romanyukha A, Saba JD, Weisdorf DJ, Wojcik A, Yukihara EG, Pellmar TC

Sphingosine 1-phosphate lyase deficiency disrupts lipid homeostasis in liver.

The Journal of biological chemistry

Bektas M, Allende ML, Lee BG, Chen W, Amar MJ, Remaley AT, Saba JD, Proia RL

Cancer treatment strategies targeting sphingolipid metabolism.

Advances in experimental medicine and biology

Oskouian B, Saba JD

Natural sphingadienes inhibit Akt-dependent signaling and prevent intestinal tumorigenesis.

Cancer research

Fyrst H, Oskouian B, Bandhuvula P, Gong Y, Byun HS, Bittman R, Lee AR, Saba JD

Normalization of diabetic wound healing.

Surgery

Francis-Goforth KN, Harken AH, Saba JD

Lyase to live by: sphingosine phosphate lyase as a therapeutic target.

Expert opinion on therapeutic targets

Kumar A, Saba JD

Sphingosine 1-phosphate lyase enzyme assay using a BODIPY-labeled substrate.

Biochemical and biophysical research communications

Bandhuvula P, Li Z, Bittman R, Saba JD

Activation of sphingosine kinase-1 reverses the increase in lung vascular permeability through sphingosine-1-phosphate receptor signaling in endothelial cells.

Circulation research

Tauseef M, Kini V, Knezevic N, Brannan M, Ramchandaran R, Fyrst H, Saba J, Vogel SM, Malik AB, Mehta D

Identification and characterization by electrospray mass spectrometry of endogenous Drosophila sphingadienes.

Journal of lipid research

Fyrst H, Zhang X, Herr DR, Byun HS, Bittman R, Phan VH, Harris GL, Saba JD

A rapid fluorescence assay for sphingosine-1-phosphate lyase enzyme activity.

Journal of lipid research

Bandhuvula P, Fyrst H, Saba JD

Disruption of sphingolipid metabolism elicits apoptosis-associated reproductive defects in Drosophila.

Developmental biology

Phan VH, Herr DR, Panton D, Fyrst H, Saba JD, Harris GL

Sphingosine-1-phosphate lyase in immunity and cancer: silencing the siren.

Trends in molecular medicine

Bandhuvula P, Saba JD

Redirection of sphingolipid metabolism toward de novo synthesis of ethanolamine in Leishmania.

The EMBO journal

Zhang K, Pompey JM, Hsu FF, Key P, Bandhuvula P, Saba JD, Turk J, Beverley SM

Sphingosine-1-phosphate lyase potentiates apoptosis via p53- and p38-dependent pathways and is down-regulated in colon cancer.

Proceedings of the National Academy of Sciences of the United States of America

Oskouian B, Sooriyakumaran P, Borowsky AD, Crans A, Dillard-Telm L, Tam YY, Bandhuvula P, Saba JD

Intracellular role for sphingosine kinase 1 in intestinal adenoma cell proliferation.

Molecular and cellular biology

Kohno M, Momoi M, Oo ML, Paik JH, Lee YM, Venkataraman K, Ai Y, Ristimaki AP, Fyrst H, Sano H, Rosenberg D, Saba JD, Proia RL, Hla T

Sphingosine 1-phosphate/sphingosine 1-phosphate receptor 1 signaling in rheumatoid synovium: regulation of synovial proliferation and inflammatory gene expression.

Arthritis and rheumatism

Kitano M, Hla T, Sekiguchi M, Kawahito Y, Yoshimura R, Miyazawa K, Iwasaki T, Sano H, Saba JD, Tam YY

Sphingosine-1-Phosphate Lyase.

Sphingolipid Biology

Julie D. Saba

Directed Donor Cord Blood Transplantation for Hematological Disorders.

Blood

Mark C. Walters, Lynn Quirolo, Sandie Edwards, Joanna Lee, Shanda Robertson, Julie D. Saba, Elizabeth Trachtenberg, Keith C. Quirolo, Bert Lubin

The immune modulator FTY720 inhibits sphingosine-1-phosphate lyase activity.

The Journal of biological chemistry

Bandhuvula P, Tam YY, Oskouian B, Saba JD

Regulation of sphingosine-1-phosphate lyase gene expression by members of the GATA family of transcription factors.

The Journal of biological chemistry

Oskouian B, Mendel J, Shocron E, Lee MA, Fyrst H, Saba JD

Sibling donor cord blood transplantation for thalassemia major: Experience of the Sibling Donor Cord Blood Program.

Annals of the New York Academy of Sciences

Walters MC, Quirolo L, Trachtenberg ET, Edwards S, Hale L, Lee J, Morton-Wiley J, Quirolo K, Robertson S, Saba J, Lubin B

gamma-Tocopherol or combinations of vitamin E forms induce cell death in human prostate cancer cells by interrupting sphingolipid synthesis.

Proceedings of the National Academy of Sciences of the United States of America

Jiang Q, Wong J, Fyrst H, Saba JD, Ames BN

Death and taxis: what non-mammalian models tell us about sphingosine-1-phosphate.

Seminars in cell & developmental biology

Oskouian B, Saba JD

Lysophospholipids in development: Miles apart and edging in.

Journal of cellular biochemistry

Saba JD

Characterization of the Drosophila sphingosine kinases and requirement for Sk2 in normal reproductive function.

The Journal of biological chemistry

Herr DR, Fyrst H, Creason MB, Phan VH, Saba JD, Harris GL

Sphingosine-phosphate lyase enhances stress-induced ceramide generation and apoptosis.

The Journal of biological chemistry

Reiss U, Oskouian B, Zhou J, Gupta V, Sooriyakumaran P, Kelly S, Wang E, Merrill AH, Saba JD

Characterization of free endogenous C14 and C16 sphingoid bases from Drosophila melanogaster.

Journal of lipid research

Fyrst H, Herr DR, Harris GL, Saba JD

Sply regulation of sphingolipid signaling molecules is essential for Drosophila development.

Development (Cambridge, England)

Herr DR, Fyrst H, Phan V, Heinecke K, Georges R, Harris GL, Saba JD

Sphingosine phosphate lyase expression is essential for normal development in Caenorhabditis elegans.

The Journal of biological chemistry

Mendel J, Heinecke K, Fyrst H, Saba JD

Comprehensive banking of sibling donor cord blood for children with malignant and nonmalignant disease.

Blood

Reed W, Smith R, Dekovic F, Lee JY, Saba JD, Trachtenberg E, Epstein J, Haaz S, Walters MC, Lubin BH

Calcium influx and signaling in yeast stimulated by intracellular sphingosine 1-phosphate accumulation.

The Journal of biological chemistry

Birchwood CJ, Saba JD, Dickson RC, Cunningham KW

Molecular cloning - and functional characterization of the human sphingosine-1 -phosphate lyase gene.

Journal of pediatric hematology/oncology

J. Zhou, U. Reiss, J. D. Saba

The DPL1 gene is involved in mediating the response to nutrient deprivation in Saccharomyces cerevisiae.

Molecular cell biology research communications : MCBRC

Gottlieb D, Heideman W, Saba JD

The BST1 gene of Saccharomyces cerevisiae is the sphingosine-1-phosphate lyase.

The Journal of biological chemistry

Saba JD, Nara F, Bielawska A, Garrett S, Hannun YA

Ceramide: an intracellular mediator of apoptosis and growth suppression.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences

Saba JD, Obeid LM, Hannun YA

Ceramide-mediated growth inhibition and CAPP are conserved in Saccharomyces cerevisiae.

The Journal of biological chemistry

Fishbein JD, Dobrowsky RT, Bielawska A, Garrett S, Hannun YA

A seven-month-old infant with fever and neutrophilic leukocytosis.

The Journal of pediatrics

Fishbein JD, Bruggers CS, Friedman NJ, Graham ML, Kurtzberg J

Large-cell lymphoma presenting with a distinctive inflammatory dermatosis.

Journal of the American Academy of Dermatology

Tope WD, Fishbein JD, White PF, Prose NS

Pelger-Huet anomaly in an infant with multiple congenital anomalies.

American journal of hematology

Fishbein JD, Falletta JM

Catheter-related sepsis refractory to antibiotics treated successfully with adjunctive urokinase infusion.

The Pediatric infectious disease journal

Fishbein JD, Friedman HS, Bennett BB, Falletta JM

Indicator enzyme assays. II. Adenylate kinase: application to human muscle biopsies and blood cells.

Biochemical medicine

Fishbein WN, Davis JI, Winkert JW, Fishbein JD

Journal of Immunological Sciences

The low down on sphingosine-1-phosphate lyase as a regulator of thymic egress

Saba JD

Sphingosine-1-phosphate signaling and metabolism gene signature in pediatric inflammatory bowel disease: a matched-case control pilot study

Sphingosine-1-phosphate signaling and metabolism gene signature in pediatric inflammatory bowel disease: a matched-case control pilot study

Suh JH
Degagné E
Gleghorn EE
Setty M
Rodriguez A
Park KT
Verstraete SG
Heyman MB
Patel AS
Irek M
Gildengorin GL
Hubbard NE
Borowsky AD
Saba JD