Isabel Rodriguez-Barraquer, MD, PhD, MHS

Assoc Professor In Residence
Medicine
[email protected]

My research focuses in applying novel epidemiological and statistical methods to understand the dynamics of infectious diseases and inform control interventions. While I am interested in infectious diseases generally, most of my work has focused on understanding shifts in the epidemiology of vector borne diseases including dengue, leishmaniasis, chikungunya, malaria and Zika.

Publications: 

Dramatic resurgence of malaria after 7 years of intensive vector control interventions in Eastern Uganda.

medRxiv : the preprint server for health sciences

Kamya MR, Nankabirwa JI, Arinaitwe E, Rek J, Zedi M, Maiteki-Sebuguzi C, Opigo J, Staedke SG, Oruni A, Donnelly MJ, Greenhouse B, Briggs J, Krezanoski PJ, Bousema T, Rosenthal PJ, Olwoch P, Jagannathan P, Rodriguez-Barraquer I, Dorsey G

Household immunity and individual risk of infection with dengue virus in a prospective, longitudinal cohort study.

Nature microbiology

Hamins-Puértolas M, Buddhari D, Salje H, Cummings DAT, Fernandez S, Farmer A, Kaewhiran S, Khampaen D, Iamsirithaworn S, Srikiatkhachorn A, Waickman A, Thomas SJ, Rothman AL, Endy T, Rodriguez-Barraquer I, Anderson KB

Maternally derived antibody titer dynamics and risk of hospitalized infant dengue disease.

Proceedings of the National Academy of Sciences of the United States of America

O'Driscoll M, Buddhari D, Huang AT, Waickman A, Kaewhirun S, Iamsirithaworn S, Khampaen D, Farmer A, Fernandez S, Rodriguez-Barraquer I, Srikiatkhachorn A, Thomas S, Endy T, Rothman AL, Anderson K, Cummings DAT, Salje H

SARS-CoV-2 Serology Across Scales: A Framework for Unbiased Estimation of Cumulative Incidence Incorporating Antibody Kinetics and Epidemic Recency.

American journal of epidemiology

Takahashi S, Peluso MJ, Hakim J, Turcios K, Janson O, Routledge I, Busch MP, Hoh R, Tai V, Kelly JD, Martin JN, Deeks SG, Henrich TJ, Greenhouse B, Rodríguez-Barraquer I

Metagenomic next-generation sequencing to characterize potential etiologies of non-malarial fever in a cohort living in a high malaria burden area of Uganda.

PLOS Global Public Health

Mwakibete L, Takahashi S, Ahyong V, Black A, Rek J, Ssewanyana I, Kamya M, Dorsey G, Jagannathan P, Rodríguez-Barraquer I, Tato CM, Greenhouse B

Mapping malaria incidence using routine health facility surveillance data in Uganda.

BMJ global health

Epstein A, Namuganga JF, Nabende I, Kamya EV, Kamya MR, Dorsey G, Sturrock H, Bhatt S, Rodríguez-Barraquer I, Greenhouse B

Proteome-wide antigenic profiling in Ugandan cohorts identifies associations between age, exposure intensity, and responses to repeat-containing antigens in Plasmodium falciparum.

eLife

Raghavan M, Kalantar KL, Duarte E, Teyssier N, Takahashi S, Kung AF, Rajan JV, Rek J, Tetteh KKA, Drakeley C, Ssewanyana I, Rodriguez-Barraquer I, Greenhouse B, DeRisi JL

Malaria-driven expansion of adaptive-like functional CD56-negative NK cells correlates with clinical immunity to malaria.

Science translational medicine

Ty M, Sun S, Callaway PC, Rek J, Press KD, van der Ploeg K, Nideffer J, Hu Z, Klemm S, Greenleaf W, Donato M, Tukwasibwe S, Arinaitwe E, Nankya F, Musinguzi K, Andrew D, de la Parte L, Mori DM, Lewis SN, Takahashi S, Rodriguez-Barraquer I, Greenhouse B, Blish C, Utz PJ, Khatri P, Dorsey G, Kamya M, Boyle M, Feeney M, Ssewanyana I, Jagannathan P

Infectiousness of SARS-CoV-2 breakthrough infections and reinfections during the Omicron wave.

Nature medicine

Tan ST, Kwan AT, Rodríguez-Barraquer I, Singer BJ, Park HJ, Lewnard JA, Sears D, Lo NC

Early immune markers of clinical, virological, and immunological outcomes in patients with COVID-19: a multi-omics study.

eLife

Hu Z, van der Ploeg K, Chakraborty S, Arunachalam PS, Mori DAM, Jacobson KB, Bonilla H, Parsonnet J, Andrews JR, Holubar M, Subramanian A, Khosla C, Maldonado Y, Hedlin H, de la Parte L, Press K, Ty M, Tan GS, Blish C, Takahashi S, Rodriguez-Barraquer I, Greenhouse B, Butte AJ, Singh U, Pulendran B, Wang TT, Jagannathan P

East Africa International Center of Excellence for Malaria Research: Summary of Key Research Findings.

The American journal of tropical medicine and hygiene

Nankabirwa JI, Rek J, Arinaitwe E, Namuganga JF, Nsobya SL, Asua V, Mawejje HD, Epstein A, Greenhouse B, Rodriguez-Barraquer I, Briggs J, Krezanoski PJ, Rosenthal PJ, Conrad M, Smith D, Staedke SG, Drakeley C, Bousema T, Andolina C, Donnelly MJ, Kamya MR, Dorsey G

Building an integrated serosurveillance platform to inform public health interventions: Insights from an experts' meeting on serum biomarkers.

PLoS neglected tropical diseases

Wiens KE, Jauregui B, Arnold BF, Banke K, Wade D, Hayford K, Costero-Saint Denis A, Hall RH, Salje H, Rodriguez-Barraquer I, Azman AS, Vernet G, Leung DT, Collaboration on Integrated Biomarkers Surveillance

Simulating the Impacts of Augmenting Intensive Vector Control with Mass Drug Administration or Test-and-Treat Strategies on the Malaria Infectious Reservoir.

The American journal of tropical medicine and hygiene

Nankabirwa JI, Arinaitwe E, Briggs J, Rek J, Rosenthal PJ, Kamya MR, Olwoch P, Smith DL, Rodriguez-Barraquer I, Dorsey G, Greenhouse B

Dcifer: an IBD-based method to calculate genetic distance between polyclonal infections.

Genetics

Gerlovina I, Gerlovin B, Rodríguez-Barraquer I, Greenhouse B

Resurgence of malaria in Uganda despite sustained indoor residual spraying and repeated long lasting insecticidal net distributions.

PLOS Global Public Health

Adrienne Epstein, Catherine Maiteki-Sebuguzi, Jane F. Namuganga, Joaniter I. Nankabirwa, Samuel Gonahasa, Jimmy Opigo, Sarah G. Staedke, Damian Rutazaana, Emmanuel Arinaitwe, Moses R. Kamya, Samir Bhatt, Isabel Rodríguez-Barraquer, Bryan Greenhouse, Martin J. Donnelly, Grant Dorsey

Resurgence of malaria in Uganda despite sustained indoor residual spraying and repeated long lasting insecticidal net distributions.

PLOS Global Public Health

Epstein A, Maiteki-Sebuguzi C, Namuganga JF, Nankabirwa JI, Gonahasa S, Opigo J, Staedke SG, Rutazaana D, Arinaitwe E, Kamya MR, Bhatt S, Rodríguez-Barraquer I, Greenhouse B, Donnelly MJ, Dorsey G

Genetic variation that determines TAPBP expression levels associates with the course of malaria in an HLA allotype-dependent manner.

Proceedings of the National Academy of Sciences of the United States of America

Walker-Sperling V, Digitale JC, Viard M, Martin MP, Bashirova A, Yuki Y, Ramsuran V, Kulkarni S, Naranbhai V, Li H, Anderson SK, Yum L, Clifford R, Kibuuka H, Ake J, Thomas R, Rowland-Jones S, Rek J, Arinaitwe E, Kamya M, Rodriguez-Barraquer I, Feeney ME, Carrington M

Assessing the role of multiple mechanisms increasing the age of dengue cases in Thailand.

Proceedings of the National Academy of Sciences of the United States of America

Huang AT, Takahashi S, Salje H, Wang L, Garcia-Carreras B, Anderson K, Endy T, Thomas S, Rothman AL, Klungthong C, Jones AR, Fernandez S, Iamsirithaworn S, Doung-Ngern P, Rodriguez-Barraquer I, Cummings DAT

Using sero-epidemiology to monitor disparities in vaccination and infection with SARS-CoV-2.

Nature communications

Routledge I, Takahashi S, Epstein A, Hakim J, Janson O, Turcios K, Vinden J, Risos JT, Baniqued MR, Pham L, Di Germanio C, Busch M, Kushel M, Greenhouse B, Rodríguez-Barraquer I

TNF-α+ CD4+ T cells dominate the SARS-CoV-2 specific T cell response in COVID-19 outpatients and are associated with durable antibodies.

Cell reports. Medicine

van der Ploeg K, Kirosingh AS, Mori DAM, Chakraborty S, Hu Z, Sievers BL, Jacobson KB, Bonilla H, Parsonnet J, Andrews JR, Press KD, Ty MC, Ruiz-Betancourt DR, de la Parte L, Tan GS, Blish CA, Takahashi S, Rodriguez-Barraquer I, Greenhouse B, Singh U, Wang TT, Jagannathan P

Beneath the surface: Amino acid variation underlying two decades of dengue virus antigenic dynamics in Bangkok, Thailand.

PLoS pathogens

Huang AT, Salje H, Escoto AC, Chowdhury N, Chávez C, Garcia-Carreras B, Rutvisuttinunt W, Maljkovic Berry I, Gromowski GD, Wang L, Klungthong C, Thaisomboonsuk B, Nisalak A, Trimmer-Smith LM, Rodriguez-Barraquer I, Ellison DW, Jones AR, Fernandez S, Thomas SJ, Smith DJ, Jarman R, Whitehead SS, Cummings DAT, Katzelnick LC

COVID-19 Vaccination and Estimated Public Health Impact in California.

JAMA network open

Tan ST, Park HJ, Rodríguez-Barraquer I, Rutherford GW, Bibbins-Domingo K, Schechter R, Lo NC

Risk factor targeting for vaccine prioritization during the COVID-19 pandemic.

Scientific reports

Chapman LAC, Shukla P, Rodríguez-Barraquer I, Shete PB, León TM, Bibbins-Domingo K, Rutherford GW, Schechter R, Lo NC

Seroprevalence of anti-SARS-CoV-2 antibodies in Colombia, 2020: A population-based study.

Lancet Regional Health. Americas

Mercado-Reyes M, Malagón-Rojas J, Rodríguez-Barraquer I, Zapata-Bedoya S, Wiesner M, Cucunubá Z, Toloza-Pérez YG, Hernández-Ortiz JP, Acosta-Reyes J, Parra-Barrera E, Ibáñez-Beltrán E, Quinche GG, Muñoz-Galindo L, Rubio V, Galindo-Borda M, Osorio-Velázquez EG, Bermúdez-Forero A, Pinto-Chacón N, Puerto-Castro G, Franco-Muñoz C, Estupiñan MI, Villar LÁ, Gore-Saravia N, Miranda-Montoya MC, Castellanos J, Valle EM, Navarro-Lechuga E, Oviedo JD, Ospina-Martínez M

Early immune responses have long-term associations with clinical, virologic, and immunologic outcomes in patients with COVID-19.

Research square

Hu Z, van der Ploeg K, Chakraborty S, Arunachalam P, Mori D, Jacobson K, Bonilla H, Parsonnet J, Andrews J, Hedlin H, de la Parte L, Dantzler K, Ty M, Tan G, Blish C, Takahashi S, Rodriguez-Barraquer I, Greenhouse B, Butte A, Singh U, Pulendran B, Wang T, Jagannathan P

Persistence, Magnitude, and Patterns of Postacute Symptoms and Quality of Life Following Onset of SARS-CoV-2 Infection: Cohort Description and Approaches for Measurement.

Open forum infectious diseases

Peluso MJ, Kelly JD, Lu S, Goldberg SA, Davidson MC, Mathur S, Durstenfeld MS, Spinelli MA, Hoh R, Tai V, Fehrman EA, Torres L, Hernandez Y, Williams MC, Arreguin MI, Ngo LH, Deswal M, Munter SE, Martinez EO, Anglin KA, Romero MD, Tavs J, Rugart PR, Chen JY, Sans HM, Murray VW, Ellis PK, Donohue KC, Massachi JA, Weiss JO, Mehdi I, Pineda-Ramirez J, Tang AF, Wenger MA, Assenzio MT, Yuan Y, Krone MR, Rutishauser RL, Rodriguez-Barraquer I, Greenhouse B, Sauceda JA, Gandhi M, Scheffler AW, Hsue PY, Henrich TJ, Deeks SG, Martin JN

Age-Related Changes in Malaria Clinical Phenotypes During Infancy Are Modified by Sickle Cell Trait.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Zehner N, Adrama H, Kakuru A, Andra T, Kajubi R, Conrad M, Nankya F, Clark TD, Kamya M, Rodriguez-Barraquer I, Dorsey G, Jagannathan P

Using sero-epidemiology to monitor disparities in vaccination and infection with SARS-CoV-2.

medRxiv : the preprint server for health sciences

Routledge I, Takahashi S, Epstein A, Hakim J, Janson O, Turcios K, Vinden J, Risos JT, Baniqued MR, Pham L, Di Germanio C, Busch M, Kushel M, Greenhouse B, Rodríguez-Barraquer I

SARS-CoV-2 serology across scales: a framework for unbiased seroprevalence estimation incorporating antibody kinetics and epidemic recency.

medRxiv : the preprint server for health sciences

Takahashi S, Peluso MJ, Hakim J, Turcios K, Janson O, Routledge I, Busch MP, Hoh R, Tai V, Kelly JD, Martin JN, Deeks SG, Henrich TJ, Greenhouse B, Rodríguez-Barraquer I

Trade-offs between individual and ensemble forecasts of an emerging infectious disease.

Nature communications

Oidtman RJ, Omodei E, Kraemer MUG, Castañeda-Orjuela CA, Cruz-Rivera E, Misnaza-Castrillón S, Cifuentes MP, Rincon LE, Cañon V, Alarcon P, España G, Huber JH, Hill SC, Barker CM, Johansson MA, Manore CA, Reiner RC, Rodriguez-Barraquer I, Siraj AS, Frias-Martinez E, García-Herranz M, Perkins TA

Long-term SARS-CoV-2-specific immune and inflammatory responses in individuals recovering from COVID-19 with and without post-acute symptoms.

Cell reports

Peluso MJ, Deitchman AN, Torres L, Iyer NS, Munter SE, Nixon CC, Donatelli J, Thanh C, Takahashi S, Hakim J, Turcios K, Janson O, Hoh R, Tai V, Hernandez Y, Fehrman EA, Spinelli MA, Gandhi M, Trinh L, Wrin T, Petropoulos CJ, Aweeka FT, Rodriguez-Barraquer I, Kelly JD, Martin JN, Deeks SG, Greenhouse B, Rutishauser RL, Henrich TJ

SARS-CoV-2 antibody magnitude and detectability are driven by disease severity, timing, and assay.

Science advances

Peluso MJ, Takahashi S, Hakim J, Kelly JD, Torres L, Iyer NS, Turcios K, Janson O, Munter SE, Thanh C, Donatelli J, Nixon CC, Hoh R, Tai V, Fehrman EA, Hernandez Y, Spinelli MA, Gandhi M, Palafox MA, Vallari A, Rodgers MA, Prostko J, Hackett J, Trinh L, Wrin T, Petropoulos CJ, Chiu CY, Norris PJ, DiGermanio C, Stone M, Busch MP, Elledge SK, Zhou XX, Wells JA, Shu A, Kurtz TW, Pak JE, Wu W, Burbelo PD, Cohen JI, Rutishauser RL, Martin JN, Deeks SG, Henrich TJ, Rodriguez-Barraquer I, Greenhouse B

Association of Inhibitory Killer Cell Immunoglobulin-like Receptor Ligands With Higher Plasmodium falciparum Parasite Prevalence.

The Journal of infectious diseases

Digitale JC, Callaway PC, Martin M, Nelson G, Viard M, Rek J, Arinaitwe E, Dorsey G, Kamya M, Carrington M, Rodriguez-Barraquer I, Feeney ME

Evaluation of the extended efficacy of the Dengvaxia vaccine against symptomatic and subclinical dengue infection.

Nature medicine

Salje H, Alera MT, Chua MN, Hunsawong T, Ellison D, Srikiatkhachorn A, Jarman RG, Gromowski GD, Rodriguez-Barraquer I, Cauchemez S, Cummings DAT, Macareo L, Yoon IK, Fernandez S, Rothman AL

Sources of persistent malaria transmission in a setting with effective malaria control in eastern Uganda: a longitudinal, observational cohort study.

The Lancet. Infectious diseases

Andolina C, Rek JC, Briggs J, Okoth J, Musiime A, Ramjith J, Teyssier N, Conrad M, Nankabirwa JI, Lanke K, Rodriguez-Barraquer I, Meerstein-Kessel L, Arinaitwe E, Olwoch P, Rosenthal PJ, Kamya MR, Dorsey G, Greenhouse B, Drakeley C, Staedke SG, Bousema T

Citywide serosurveillance of the initial SARS-CoV-2 outbreak in San Francisco using electronic health records.

Nature communications

Routledge I, Epstein A, Takahashi S, Janson O, Hakim J, Duarte E, Turcios K, Vinden J, Sujishi K, Rangel J, Coh M, Besana L, Ho WK, Oon CY, Ong CM, Yun C, Lynch K, Wu AHB, Wu W, Karlon W, Thornborrow E, Peluso MJ, Henrich TJ, Pak JE, Briggs J, Greenhouse B, Rodriguez-Barraquer I

The impact of stopping and starting indoor residual spraying on malaria burden in Uganda.

Nature communications

Namuganga JF, Epstein A, Nankabirwa JI, Mpimbaza A, Kiggundu M, Sserwanga A, Kapisi J, Arinaitwe E, Gonahasa S, Opigo J, Ebong C, Staedke SG, Shililu J, Okia M, Rutazaana D, Maiteki-Sebuguzi C, Belay K, Kamya MR, Dorsey G, Rodriguez-Barraquer I

Comparison of infection control strategies to reduce COVID-19 outbreaks in homeless shelters in the United States: a simulation study.

BMC medicine

Chapman LAC, Kushel M, Cox SN, Scarborough A, Cawley C, Nguyen TQ, Rodriguez-Barraquer I, Greenhouse B, Imbert E, Lo NC

Routine asymptomatic testing strategies for airline travel during the COVID-19 pandemic: a simulation study.

The Lancet. Infectious diseases

Kiang MV, Chin ET, Huynh BQ, Chapman LAC, Rodríguez-Barraquer I, Greenhouse B, Rutherford GW, Bibbins-Domingo K, Havlir D, Basu S, Lo NC

HLA Alleles B*53:01 and C*06:02 Are Associated With Higher Risk of P. falciparum Parasitemia in a Cohort in Uganda.

Frontiers in immunology

Digitale JC, Callaway PC, Martin M, Nelson G, Viard M, Rek J, Arinaitwe E, Dorsey G, Kamya M, Carrington M, Rodriguez-Barraquer I, Feeney ME

Rapid implementation of a cohort for the study of post-acute sequelae of SARS-CoV-2 infection/COVID-19.

medRxiv : the preprint server for health sciences

Peluso MJ, Kelly JD, Lu S, Goldberg SA, Davidson MC, Mathur S, Durstenfeld MS, Spinelli MA, Hoh R, Tai V, Fehrman EA, Torres L, Hernandez Y, Williams MC, Arreguin MI, Bautista JA, Ngo LH, Deswal M, Munter SE, Martinez EO, Anglin KA, Romero MD, Tavs J, Rugart PR, Chen JY, Sans HM, Murray VW, Ellis PK, Donohue KC, Massachi JA, Weiss JO, Mehdi I, Pineda-Ramirez J, Tang AF, Wenger M, Assenzio M, Yuan Y, Krone M, Rutishauser RL, Rodriguez-Barraquer I, Greenhouse B, Sauceda JA, Gandhi M, Hsue PY, Henrich TJ, Deeks SG, Martin JN

SARS-CoV-2 antibody magnitude and detectability are driven by disease severity, timing, and assay.

medRxiv : the preprint server for health sciences

Peluso MJ, Takahashi S, Hakim J, Kelly JD, Torres L, Iyer NS, Turcios K, Janson O, Munter SE, Thanh C, Nixon CC, Hoh R, Tai V, Fehrman EA, Hernandez Y, Spinelli MA, Gandhi M, Palafox MA, Vallari A, Rodgers MA, Prostko J, Hackett J, Trinh L, Wrin T, Petroplolous CJ, Chiu CY, Norris PJ, DiGermanio C, Stone M, Busch MP, Elledge SK, Zhou XX, Wells JA, Shu A, Kurtz TW, Pak JE, Wu W, Burbelo PD, Cohen JI, Rutishauser RL, Martin JN, Deeks SG, Henrich TJ, Rodriguez-Barraquer I, Greenhouse B

Long-Term SARS-CoV-2-Specific Immune and Inflammatory Responses Across a Clinically Diverse Cohort of Individuals Recovering from COVID-19.

medRxiv : the preprint server for health sciences

Peluso MJ, Deitchman AN, Torres L, Iyer NS, Nixon CC, Munter SE, Donatelli J, Thanh C, Takahashi S, Hakim J, Turcios K, Janson O, Hoh R, Tai V, Hernandez Y, Fehrman E, Spinelli MA, Gandhi M, Trinh L, Wrin T, Petropoulos CJ, Aweeka FT, Rodriguez-Barraquer I, Kelly JD, Martin JN, Deeks SG, Greenhouse B, Rutishauser RL, Henrich TJ

Characterization and Biomarker Analyses of Post-COVID-19 Complications and Neurological Manifestations.

Cells

Sun B, Tang N, Peluso MJ, Iyer NS, Torres L, Donatelli JL, Munter SE, Nixon CC, Rutishauser RL, Rodriguez-Barraquer I, Greenhouse B, Kelly JD, Martin JN, Deeks SG, Henrich TJ, Pulliam L

Citywide serosurveillance of the initial SARS-CoV-2 outbreak in San Francisco.

Research square

Routledge I, Epstein A, Takahashi S, Janson O, Hakim J, Duarte E, Turcios K, Vinden J, Sujishi K, Rangel J, Coh M, Besana L, Ho WK, Oon CY, Ong CM, Yun C, Lynch K, Wu AHB, Wu W, Karlon W, Thornborrow E, Peluso MJ, Henrich TJ, Pak JE, Briggs J, Greenhouse B, Rodriguez-Barraquer I

Within-household clustering of genetically related Plasmodium falciparum infections in a moderate transmission area of Uganda.

Malaria journal

Briggs J, Kuchta A, Murphy M, Tessema S, Arinaitwe E, Rek J, Chen A, Nankabirwa JI, Drakeley C, Smith D, Bousema T, Kamya M, Rodriguez-Barraquer I, Staedke S, Dorsey G, Rosenthal PJ, Greenhouse B

Influenza, Varicella, and Mumps Outbreaks in US Migrant Detention Centers.

JAMA

Lo NC, Nyathi S, Chapman LAC, Rodriguez-Barraquer I, Kushel M, Bibbins-Domingo K, Lewnard JA

Routine asymptomatic testing strategies for airline travel during the COVID-19 pandemic: a simulation analysis.

medRxiv : the preprint server for health sciences

Kiang MV, Chin ET, Huynh BQ, Chapman LAC, Rodríguez-Barraquer I, Greenhouse B, Rutherford GW, Bibbins-Domingo K, Havlir D, Basu S, Lo NC

Estimating malaria incidence from routine health facility-based surveillance data in Uganda.

Malaria journal

Epstein A, Namuganga JF, Kamya EV, Nankabirwa JI, Bhatt S, Rodriguez-Barraquer I, Staedke SG, Kamya MR, Dorsey G, Greenhouse B

Are Seroprevalence Estimates for Severe Acute Respiratory Syndrome Coronavirus 2 Biased?

The Journal of infectious diseases

Takahashi S, Greenhouse B, Rodríguez-Barraquer I

Universal PCR and antibody testing demonstrate little to no transmission of SARS-CoV-2 in a rural community.

Open forum infectious diseases

Ayesha Appa, Saki Takahashi, Isabel Rodriguez-Barraquer, Gabriel Chamie, Aenor Sawyer, Elias Duarte, Jill Hakim, Keirstinne Turcios, Joanna Vinden, Owen Janson, Aashish Manglik, Michael J Peluso, Steven G Deeks, Timothy J Henrich, Leonel Torres, Mary Rodgers, John Hackett, Charles Chiu, Diane Havlir, Bryan Greenhouse

Universal Polymerase Chain Reaction and Antibody Testing Demonstrate Little to No Transmission of Severe Acute Respiratory Syndrome Coronavirus 2 in a Rural Community.

Open forum infectious diseases

Appa A, Takahashi S, Rodriguez-Barraquer I, Chamie G, Sawyer A, Duarte E, Hakim J, Turcios K, Vinden J, Janson O, Manglik A, Peluso MJ, Deeks SG, Henrich TJ, Torres L, Rodgers M, Hackett J, Chiu C, Havlir D, Greenhouse B

Sex-based differences in clearance of chronic Plasmodium falciparum infection.

eLife

Briggs J, Teyssier N, Nankabirwa JI, Rek J, Jagannathan P, Arinaitwe E, Bousema T, Drakeley C, Murray M, Crawford E, Hathaway N, Staedke SG, Smith D, Rosenthal PJ, Kamya M, Dorsey G, Rodriguez-Barraquer I, Greenhouse B

Malaria Transmission, Infection, and Disease following Sustained Indoor Residual Spraying of Insecticide in Tororo, Uganda.

The American journal of tropical medicine and hygiene

Nankabirwa JI, Arinaitwe E, Rek J, Kilama M, Kizza T, Staedke SG, Rosenthal PJ, Rodriguez-Barraquer I, Briggs J, Greenhouse B, Bousema T, Drakeley C, Roos DS, Tomko SS, Smith DL, Kamya MR, Dorsey G

A systematic review of antibody mediated immunity to coronaviruses: kinetics, correlates of protection, and association with severity.

Nature communications

Huang AT, Garcia-Carreras B, Hitchings MDT, Yang B, Katzelnick LC, Rattigan SM, Borgert BA, Moreno CA, Solomon BD, Trimmer-Smith L, Etienne V, Rodriguez-Barraquer I, Lessler J, Salje H, Burke DS, Wesolowski A, Cummings DAT

Heterogeneity of dengue transmission in an endemic area of Colombia.

PLoS neglected tropical diseases

Estupiñán Cárdenas MI, Herrera VM, Miranda Montoya MC, Lozano Parra A, Zaraza Moncayo ZM, Flórez García JP, Rodríguez Barraquer I, Villar Centeno LÁ

Universal PCR and antibody testing demonstrate little to no transmission of SARS-CoV-2 in a rural community.

medRxiv : the preprint server for health sciences

Appa A, Takahashi S, Rodriguez-Barraquer I, Chamie G, Sawyer A, Consortium C, Duarte E, Hakim J, Turcios K, Vinden J, Janson O, Manglik A, Peluso MJ, Deeks SG, Henrich TJ, Torres L, Rodgers M, Hackett J, Chiu C, Havlir D, Greenhouse B

Serology for SARS-CoV-2: Apprehensions, opportunities, and the path forward.

Science immunology

Bryant JE, Azman AS, Ferrari MJ, Arnold BF, Boni MF, Boum Y, Hayford K, Luquero FJ, Mina MJ, Rodriguez-Barraquer I, Wu JT, Wade D, Vernet G, Leung DT

The Impact of Control Interventions on Malaria Burden in Young Children in a Historically High-Transmission District of Uganda: A Pooled Analysis of Cohort Studies from 2007 to 2018.

The American journal of tropical medicine and hygiene

Kamya MR, Kakuru A, Muhindo M, Arinaitwe E, Nankabirwa JI, Rek J, Bigira V, Kapisi J, Wanzira H, Achan J, Natureeba P, Gasasira A, Havlir D, Jagannathan P, Rosenthal PJ, Rodriguez-Barraquer I, Dorsey G

A systematic review of antibody mediated immunity to coronaviruses: antibody kinetics, correlates of protection, and association of antibody responses with severity of disease.

medRxiv : the preprint server for health sciences

Huang AT, Garcia-Carreras B, Hitchings MDT, Yang B, Katzelnick LC, Rattigan SM, Borgert BA, Moreno CA, Solomon BD, Rodriguez-Barraquer I, Lessler J, Salje H, Burke D, Wesolowski A, Cummings DAT

Rapid shifts in the age-specific burden of malaria following successful control interventions in four regions of Uganda.

Malaria journal

Kigozi SP, Kigozi RN, Epstein A, Mpimbaza A, Sserwanga A, Yeka A, Nankabirwa JI, Halliday K, Pullan RL, Rutazaana D, Sebuguzi CM, Opigo J, Kamya MR, Staedke SG, Dorsey G, Greenhouse B, Rodriguez-Barraquer I

Mapping global variation in dengue transmission intensity.

Science translational medicine

Cattarino L, Rodriguez-Barraquer I, Imai N, Cummings DAT, Ferguson NM

Associations between red blood cell variants and malaria among children and adults from three areas of Uganda: a prospective cohort study.

Malaria journal

Kakande E, Greenhouse B, Bajunirwe F, Drakeley C, Nankabirwa JI, Walakira A, Nsobya SL, Katureebe A, Rek J, Arinaitwe E, Rosenthal PJ, Kamya MR, Dorsey G, Rodriguez-Barraquer I

The Impact of Multiple Rounds of Indoor Residual Spraying on Malaria Incidence and Hemoglobin Levels in a High-Transmission Setting.

The Journal of infectious diseases

Zinszer K, Charland K, Vahey S, Jahagirdar D, Rek JC, Arinaitwe E, Nankabirwa J, Morrison K, Sadoine ML, Tutt-Guérette MA, Staedke SG, Kamya MR, Greenhouse B, Rodriguez-Barraquer I, Dorsey G

Impacts of Zika emergence in Latin America on endemic dengue transmission.

Nature communications

Borchering RK, Huang AT, Mier-Y-Teran-Romero L, Rojas DP, Rodriguez-Barraquer I, Katzelnick LC, Martinez SD, King GD, Cinkovich SC, Lessler J, Cummings DAT

Pareto rules for malaria super-spreaders and super-spreading.

Nature communications

Cooper L, Kang SY, Bisanzio D, Maxwell K, Rodriguez-Barraquer I, Greenhouse B, Drakeley C, Arinaitwe E, G Staedke S, Gething PW, Eckhoff P, Reiner RC, Hay SI, Dorsey G, Kamya MR, Lindsay SW, Grenfell BT, Smith DL

Serological inference of past primary and secondary dengue infection: implications for vaccination.

Journal of the Royal Society, Interface

Lam HM, Phuong HT, Thao Vy NH, Le Thanh NT, Dung PN, Ngoc Muon TT, Van Vinh Chau N, Rodríguez-Barraquer I, Cummings DAT, Wills BA, Boni MF, Rabaa MA, Clapham HE

Heterogeneous local dynamics revealed by classification analysis of spatially disaggregated time series data.

Epidemics

Perkins TA, Rodriguez-Barraquer I, Manore C, Siraj AS, España G, Barker CM, Johansson MA, Reiner RC

Impact of Microscopic and Submicroscopic Parasitemia During Pregnancy on Placental Malaria in a High-Transmission Setting in Uganda.

The Journal of infectious diseases

Briggs J, Ategeka J, Kajubi R, Ochieng T, Kakuru A, Ssemanda C, Wasswa R, Jagannathan P, Greenhouse B, Rodriguez-Barraquer I, Kamya M, Dorsey G

Nationally-representative serostudy of dengue in Bangladesh allows generalizable disease burden estimates.

eLife

Salje H, Paul KK, Paul R, Rodriguez-Barraquer I, Rahman Z, Alam MS, Rahman M, Al-Amin HM, Heffelfinger J, Gurley E

Persistent Parasitemia Despite Dramatic Reduction in Malaria Incidence After 3 Rounds of Indoor Residual Spraying in Tororo, Uganda.

The Journal of infectious diseases

Nankabirwa JI, Briggs J, Rek J, Arinaitwe E, Nayebare P, Katrak S, Staedke SG, Rosenthal PJ, Rodriguez-Barraquer I, Kamya MR, Dorsey G, Greenhouse B

Long-term circulation of Zika virus in Thailand: an observational study.

The Lancet. Infectious diseases

Ruchusatsawat K, Wongjaroen P, Posanacharoen A, Rodriguez-Barraquer I, Sangkitporn S, Cummings DAT, Salje H

Impact of preexisting dengue immunity on Zika virus emergence in a dengue endemic region.

Science (New York, N.Y.)

Rodriguez-Barraquer I, Costa F, Nascimento EJM, Nery N, Castanha PMS, Sacramento GA, Cruz J, Carvalho M, De Olivera D, Hagan JE, Adhikarla H, Wunder EA, Coêlho DF, Azar SR, Rossi SL, Vasilakis N, Weaver SC, Ribeiro GS, Balmaseda A, Harris E, Nogueira ML, Reis MG, Marques ETA, Cummings DAT, Ko AI

Dengue pre-vaccination screening and positive predictive values.

The Lancet. Infectious diseases

Rodríguez-Barraquer I, Salje H, Cummings DA

645: Revisiting the evidence underlying Zika travel restrictions: quantifying risk for pregnant travelers and their partners.

American Journal of Obstetrics and Gynecology

Lauren M. Kucirka, Isabel Rodriguez-Barraquer, Jeanne Sheffield, Justin Lessler

Heterogeneous exposure and hotspots for malaria vectors at three study sites in Uganda.

Gates open research

Kang SY, Battle KE, Gibson HS, Cooper LV, Maxwell K, Kamya M, Lindsay SW, Dorsey G, Greenhouse B, Rodriguez-Barraquer I, Reiner RCJ, Smith DL, Bisanzio D

Taking Sharper Pictures of Malaria with CAMERAs: Combined Antibodies to Measure Exposure Recency Assays.

The American journal of tropical medicine and hygiene

Greenhouse B, Smith DL, Rodríguez-Barraquer I, Mueller I, Drakeley CJ

Viridot: An automated virus plaque (immunofocus) counter for the measurement of serological neutralizing responses with application to dengue virus.

PLoS neglected tropical diseases

Katzelnick LC, Coello Escoto A, McElvany BD, Chávez C, Salje H, Luo W, Rodriguez-Barraquer I, Jarman R, Durbin AP, Diehl SA, Smith DJ, Whitehead SS, Cummings DAT

Dynamics and determinants of the force of infection of dengue virus from 1994 to 2015 in Managua, Nicaragua.

Proceedings of the National Academy of Sciences of the United States of America

Katzelnick LC, Ben-Shachar R, Mercado JC, Rodriguez-Barraquer I, Elizondo D, Arguello S, Nuñez A, Ojeda S, Sanchez N, Lopez Mercado B, Gresh L, Burger-Calderon R, Kuan G, Gordon A, Balmaseda A, Harris E

Quantification of anti-parasite and anti-disease immunity to malaria as a function of age and exposure.

eLife

Rodriguez-Barraquer I, Arinaitwe E, Jagannathan P, Kamya MR, Rosenthal PJ, Rek J, Dorsey G, Nankabirwa J, Staedke SG, Kilama M, Drakeley C, Ssewanyana I, Smith DL, Greenhouse B

Dihydroartemisinin-piperaquine for intermittent preventive treatment of malaria during pregnancy and risk of malaria in early childhood: A randomized controlled trial.

PLoS medicine

Jagannathan P, Kakuru A, Okiring J, Muhindo MK, Natureeba P, Nakalembe M, Opira B, Olwoch P, Nankya F, Ssewanyana I, Tetteh K, Drakeley C, Beeson J, Reiling L, Clark TD, Rodriguez-Barraquer I, Greenhouse B, Wallender E, Aweeka F, Prahl M, Charlebois ED, Feeney ME, Havlir DV, Kamya MR, Dorsey G

Reconstruction of antibody dynamics and infection histories to evaluate dengue risk.

Nature

Salje H, Cummings DAT, Rodriguez-Barraquer I, Katzelnick LC, Lessler J, Klungthong C, Thaisomboonsuk B, Nisalak A, Weg A, Ellison D, Macareo L, Yoon IK, Jarman R, Thomas S, Rothman AL, Endy T, Cauchemez S

Spatiotemporal incidence of Zika and associated environmental drivers for the 2015-2016 epidemic in Colombia.

Scientific data

Siraj AS, Rodriguez-Barraquer I, Barker CM, Tejedor-Garavito N, Harding D, Lorton C, Lukacevic D, Oates G, Espana G, Kraemer MUG, Manore C, Johansson MA, Tatem AJ, Reiner RC, Perkins TA

Heterogeneous exposure and hotspots for malaria vectors at three study sites in Uganda.

Gates open research

Su Yun Kang, Katherine E. Battle, Harry S. Gibson, Laura V. Cooper, Kilama Maxwell, Moses Kamya, Steven W. Lindsay, Grant Dorsey, Bryan Greenhouse, Isabel Rodriguez-Barraquer, Robert C. Jr. Reiner, David L. Smith, Donal Bisanzio

High Hepatitis E Seroprevalence Among Displaced Persons in South Sudan.

The American journal of tropical medicine and hygiene

Azman AS, Bouhenia M, Iyer AS, Rumunu J, Laku RL, Wamala JF, Rodriguez-Barraquer I, Lessler J, Gignoux E, Luquero FJ, Leung DT, Gurley ES, Ciglenecki I

Impact of interventions and the incidence of ebola virus disease in Liberia-implications for future epidemics.

Health policy and planning

Kirsch TD, Moseson H, Massaquoi M, Nyenswah TG, Goodermote R, Rodriguez-Barraquer I, Lessler J, Cumings DA, Peters DH

The Long-Term Safety, Public Health Impact, and Cost-Effectiveness of Routine Vaccination with a Recombinant, Live-Attenuated Dengue Vaccine (Dengvaxia): A Model Comparison Study.

PLoS medicine

Flasche S, Jit M, Rodríguez-Barraquer I, Coudeville L, Recker M, Koelle K, Milne G, Hladish TJ, Perkins TA, Cummings DA, Dorigatti I, Laydon DJ, España G, Kelso J, Longini I, Lourenco J, Pearson CA, Reiner RC, Mier-Y-Terán-Romero L, Vannice K, Ferguson N

Impact of interventions and the incidence of ebola virus disease in Liberia-implications for future epidemics.

Health policy and planning

Kirsch TD, Moseson H, Massaquoi M, Nyenswah TG, Goodermote R, Rodriguez-Barraquer I, Lessler J, Cumings D, Peters DH

Benefits and risks of the Sanofi-Pasteur dengue vaccine: Modeling optimal deployment.

Science (New York, N.Y.)

Ferguson NM, Rodríguez-Barraquer I, Dorigatti I, Mier-Y-Teran-Romero L, Laydon DJ, Cummings DA

Erratum to: Trends in the Mechanistic and Dynamic Modeling of Infectious Diseases.

Current Epidemiology Reports

Justin Lessler, Andrew S. Azman, M. Kate Grabowski, Henrik Salje, Isabel Rodriguez-Barraquer

Trends in the Mechanistic and Dynamic Modeling of Infectious Diseases.

Current Epidemiology Reports

Justin Lessler, Andrew S. Azman, M. Kate Grabowski, Henrik Salje, Isabel Rodriguez-Barraquer

Quantifying Heterogeneous Malaria Exposure and Clinical Protection in a Cohort of Ugandan Children.

The Journal of infectious diseases

Rodriguez-Barraquer I, Arinaitwe E, Jagannathan P, Boyle MJ, Tappero J, Muhindo M, Kamya MR, Dorsey G, Drakeley C, Ssewanyana I, Smith DL, Greenhouse B

Assessing the global threat from Zika virus.

Science (New York, N.Y.)

Lessler J, Chaisson LH, Kucirka LM, Bi Q, Grantz K, Salje H, Carcelen AC, Ott CT, Sheffield JS, Ferguson NM, Cummings DA, Metcalf CJ, Rodriguez-Barraquer I

Trends in the Mechanistic and Dynamic Modeling of Infectious Diseases.

Current Epidemiology Reports

Lessler J, Azman AS, Grabowski MK, Salje H, Rodriguez-Barraquer I

Predicting intensities of Zika infection and microcephaly using transmission intensities of other arboviruses.

Bulletin of the World Health Organization

Isabel Rodríguez-Barraquer, Henrik Salje, Justin Lessler, Derek AT Cummings

Dengue Vaccine in Regions of Endemic Disease.

The New England journal of medicine

Rodriguez-Barraquer I, Salje H, Cummings DA

Chapter 18 Viral Epidemiology Tracking Viruses with Smartphones and Social Media.

Viral Pathogenesis

Kaitlin Rainwater-Lovett, Isabel Rodriguez-Barraquer, William J. Moss

Dengue Virus (DENV) Neutralizing Antibody Kinetics in Children After Symptomatic Primary and Postprimary DENV Infection.

The Journal of infectious diseases

Clapham HE, Rodriguez-Barraquer I, Azman AS, Althouse BM, Salje H, Gibbons RV, Rothman AL, Jarman RG, Nisalak A, Thaisomboonsuk B, Kalayanarooj S, Nimmannitya S, Vaughn DW, Green S, Yoon IK, Cummings DA

Enhancing disease surveillance with novel data streams: challenges and opportunities.

EPJ data science

Althouse BM, Scarpino SV, Meyers LA, Ayers JW, Bargsten M, Baumbach J, Brownstein JS, Castro L, Clapham H, Cummings DA, Del Valle S, Eubank S, Fairchild G, Finelli L, Generous N, George D, Harper DR, Hébert-Dufresne L, Johansson MA, Konty K, Lipsitch M, Milinovich G, Miller JD, Nsoesie EO, Olson DR, Paul M, Polgreen PM, Priedhorsky R, Read JM, Rodríguez-Barraquer I, Smith DJ, Stefansen C, Swerdlow DL, Thompson D, Vespignani A, Wesolowski A

Reconstruction of 60 Years of Chikungunya Epidemiology in the Philippines Demonstrates Episodic and Focal Transmission.

The Journal of infectious diseases

Salje H, Cauchemez S, Alera MT, Rodriguez-Barraquer I, Thaisomboonsuk B, Srikiatkhachorn A, Lago CB, Villa D, Klungthong C, Tac-An IA, Fernandez S, Velasco JM, Roque VG, Nisalak A, Macareo LR, Levy JW, Cummings D, Yoon IK

The Hidden Burden of Dengue and Chikungunya in Chennai, India.

PLoS neglected tropical diseases

Rodríguez-Barraquer I, Solomon SS, Kuganantham P, Srikrishnan AK, Vasudevan CK, Iqbal SH, Balakrishnan P, Solomon S, Mehta SH, Cummings DA

Differential efficacy of dengue vaccine by immune status.

Lancet (London, England)

Rodriguez-Barraquer I, Mier-Y-Teran-Romero L, Ferguson N, Burke DS, Cummings DAT

Robust, reproducible, industrialized, standard membrane feeding assay for assessing the transmission blocking activity of vaccines and drugs against Plasmodium falciparum.

Malaria journal

Li T, Eappen AG, Richman AM, Billingsley PF, Abebe Y, Li M, Padilla D, Rodriguez-Barraquer I, Sim BK, Hoffman SL

Estimating Potential Incidence of MERS-CoV Associated with Hajj Pilgrims to Saudi Arabia, 2014.

PLoS currents

Lessler J, Rodriguez-Barraquer I, Cummings DA, Garske T, Van Kerkhove M, Mills H, Truelove S, Hakeem R, Albarrak A, Ferguson NM, MERS-CoV Scenario Modeling Working Group, MERS-CoV Scenario Modeling Working Group

Variability in dengue titer estimates from plaque reduction neutralization tests poses a challenge to epidemiological studies and vaccine development.

PLoS neglected tropical diseases

Salje H, Rodríguez-Barraquer I, Rainwater-Lovett K, Nisalak A, Thaisomboonsuk B, Thomas SJ, Fernandez S, Jarman RG, Yoon IK, Cummings DA

A review of transmission models of dengue: a quantitative and qualitative analysis of model features.

Dengue and dengue hemorrhagic fever

T. A. Perkins, R. C. Reiner, I. Rodriguez-Barraquer, D. L. Smith, T. W. Scott, D. A. T. Cummings

Potential opportunities and perils of imperfect dengue vaccines.

Vaccine

Rodriguez-Barraquer I, Mier-y-Teran-Romero L, Schwartz IB, Burke DS, Cummings DA

Revisiting Rayong: shifting seroprofiles of dengue in Thailand and their implications for transmission and control.

American journal of epidemiology

Rodríguez-Barraquer I, Buathong R, Iamsirithaworn S, Nisalak A, Lessler J, Jarman RG, Gibbons RV, Cummings DA

Challenges in the interpretation of dengue vaccine trial results.

PLoS neglected tropical diseases

Rodriguez-Barraquer I, Mier-y-Teran-Romero L, Burke DS, Cummings DA

Variation in dengue virus plaque reduction neutralization testing: systematic review and pooled analysis.

BMC infectious diseases

Rainwater-Lovett K, Rodriguez-Barraquer I, Cummings DA, Lessler J

Noninferiority of miltefosine versus meglumine antimoniate for cutaneous leishmaniasis in children.

The Journal of infectious diseases

Rubiano LC, Miranda MC, Muvdi Arenas S, Montero LM, Rodríguez-Barraquer I, Garcerant D, Prager M, Osorio L, Rojas MX, Pérez M, Nicholls RS, Gore Saravia N

From re-emergence to hyperendemicity: the natural history of the dengue epidemic in Brazil.

PLoS neglected tropical diseases

Rodriguez-Barraquer I, Cordeiro MT, Braga C, de Souza WV, Marques ET, Cummings DA

Etiologic agent of an epidemic of cutaneous leishmaniasis in Tolima, Colombia.

The American journal of tropical medicine and hygiene

Rodríguez-Barraquer I, Góngora R, Prager M, Pacheco R, Montero LM, Navas A, Ferro C, Miranda MC, Saravia NG

Tensile bond strength and SEM evaluation of caries-affected dentin using dentin adhesives.

Journal of dental research

Nakajima M, Sano H, Burrow MF, Tagami J, Yoshiyama M, Ebisu S, Ciucchi B, Russell CM, Pashley DH