Gabrielle Rizzuto, MD, PhD

Alumni -- now faculty at MSK

Trophoblast antigens, fetal blood cell antigens, and the paradox of fetomaternal tolerance.

The Journal of experimental medicine

Rizzuto G, Erlebacher A

Establishment of fetomaternal tolerance through glycan-mediated B cell suppression.


Rizzuto G, Brooks JF, Tuomivaara ST, McIntyre TI, Ma S, Rideaux D, Zikherman J, Fisher SJ, Erlebacher A

99 T cell immunotherapies trigger neutrophil activation to eliminate tumor antigen escape variants.

Journal for immunotherapy of cancer

Daniel Hirschhorn, Sadna Budhu, David Schröder, Lukas kraehenbuehl, Anne-Laurent Flammar, Andrew Chow, Isabell Schulze, Sara Schad, Jacob Ricca, Billel Gasmi, Olivier De Henau, Levi Mangarin, David Redmond, Czrina Cortez, Cailian Liu, Aliya Holland, Mathieu Gigoux, Asrhi Arora, Katherine Panageas, Gabrielle Rizzuto, Jean Albrengues, Mikala Egeblad, Jedd Wolchok, Taha Merghoub

Cyclophosphamide enhances the antitumor potency of GITR engagement by increasing oligoclonal cytotoxic T cell fitness.

JCI insight

Hirschhorn D, Betof Warner A, Maniyar R, Chow A, Mangarin LM, Cohen AD, Hamadene L, Rizzuto GA, Budhu S, Suek N, Liu C, Houghton AN, Merghoub T, Wolchok JD

RAS interaction with Sin1 is dispensable for mTORC2 assembly and activity.

Proceedings of the National Academy of Sciences of the United States of America

Castel P, Dharmaiah S, Sale MJ, Messing S, Rizzuto G, Cuevas-Navarro A, Cheng A, Trnka MJ, Urisman A, Esposito D, Simanshu DK, McCormick F

Abstract 1795: Combination of cyclophosphamide chemotherapy with immune modulation overcomes resistance to checkpoint blockade in a pre-clinical melanoma model.

Cancer research

Allison Betof Warner, Daniel Hirschhorn, Levi M. Mangarin, Linda Hamadene, Adam D. Cohen, Gabrielle A. Rizzuto, Jedd D. Wolchok, Taha Merghoub

The prevalence of histologic acute chorioamnionitis among HIV infected pregnant women in Uganda and its association with adverse birth outcomes.

PloS one

Ategeka J, Wasswa R, Olwoch P, Kakuru A, Natureeba P, Muehlenbachs A, Kamya MR, Dorsey G, Rizzuto G

Uterine Artery Embolization following Cesarean Delivery but prior to Hysterectomy in the Management of Patients with Invasive Placenta.

Journal of vascular and interventional radiology : JVIR

Wang M, Ballah D, Wade A, Taylor AG, Rizzuto G, Li B, Lucero J, Chen LM, Kohi MP

34: Comprehensive characterization of human decidual immune cells involvement in spiral artery remodelling.

American Journal of Obstetrics and Gynecology

Shirley Greenbaum, Gabrielle Rizzuto, Marc Bosse, Leeat Keren, Shirley Kowk, Matt van de Rijn, Sean Bendall, Mike Angelo

Aspiration pneumonia in the setting of diffuse esophageal retention cysts: An autopsy case report.

Human Pathology Case Reports

Daffolyn Rachael Fels Elliott, Walter E. Finkbeiner, Gabrielle Rizzuto

Listeria monocytogenes InlP interacts with afadin and facilitates basement membrane crossing.

PLoS pathogens

Faralla C, Bastounis EE, Ortega FE, Light SH, Rizzuto G, Gao L, Marciano DK, Nocadello S, Anderson WF, Robbins JR, Theriot JA, Bakardjiev AI

H3K27me3 dynamics dictate evolving uterine states in pregnancy and parturition.

The Journal of clinical investigation

Nancy P, Siewiera J, Rizzuto G, Tagliani E, Osokine I, Manandhar P, Dolgalev I, Clementi C, Tsirigos A, Erlebacher A

Relationships between infection with Plasmodium falciparum during pregnancy, measures of placental malaria, and adverse birth outcomes.

Malaria journal

Kapisi J, Kakuru A, Jagannathan P, Muhindo MK, Natureeba P, Awori P, Nakalembe M, Ssekitoleko R, Olwoch P, Ategeka J, Nayebare P, Clark TD, Rizzuto G, Muehlenbachs A, Havlir DV, Kamya MR, Dorsey G, Gaw SL

Limited Colonization Undermined by Inadequate Early Immune Responses Defines the Dynamics of Decidual Listeriosis.

Infection and immunity

Rizzuto G, Tagliani E, Manandhar P, Erlebacher A, Bakardjiev AI

Intermittent Preventive Treatment With Dihydroartemisinin-Piperaquine for the Prevention of Malaria Among HIV-Infected Pregnant Women.

The Journal of infectious diseases

Natureeba P, Kakuru A, Muhindo M, Ochieng T, Ategeka J, Koss CA, Plenty A, Charlebois ED, Clark TD, Nzarubara B, Nakalembe M, Cohan D, Rizzuto G, Muehlenbachs A, Ruel T, Jagannathan P, Havlir DV, Kamya MR, Dorsey G

InlP, a New Virulence Factor with Strong Placental Tropism.

Infection and immunity

Faralla C, Rizzuto GA, Lowe DE, Kim B, Cooke C, Shiow LR, Bakardjiev AI

Human Placental and Decidual Organ Cultures to Study Infections at the Maternal-fetal Interface.

Journal of visualized experiments : JoVE

Rizzuto GA, Kapidzic M, Gormley M, Bakardjiev AI

Dihydroartemisinin-Piperaquine for the Prevention of Malaria in Pregnancy.

The New England journal of medicine

Kakuru A, Jagannathan P, Muhindo MK, Natureeba P, Awori P, Nakalembe M, Opira B, Olwoch P, Ategeka J, Nayebare P, Clark TD, Feeney ME, Charlebois ED, Rizzuto G, Muehlenbachs A, Havlir DV, Kamya MR, Dorsey G

Clonal Abundance of Tumor-Specific CD4(+) T Cells Potentiates Efficacy and Alters Susceptibility to Exhaustion.


Malandro N, Budhu S, Kuhn NF, Liu C, Murphy JT, Cortez C, Zhong H, Yang X, Rizzuto G, Altan-Bonnet G, Merghoub T, Wolchok JD

Retained Placenta Accreta Mimicking Choriocarcinoma.

Case reports in pathology

Kohi MP, Rizzuto GA, Fidelman N, Lucero J, Thiet MP

Enhanced responses to tumor immunization following total body irradiation are time-dependent.

PloS one

Diab A, Jenq RR, Rizzuto GA, Cohen AD, Huggins DW, Merghoub T, Engelhorn ME, Guevara-Patiño JA, Suh D, Hubbard-Lucey VM, Kochman AA, Chen S, Zhong H, Wolchok JD, van den Brink MR, Houghton AN, Perales MA

Monocytic CCR2(+) myeloid-derived suppressor cells promote immune escape by limiting activated CD8 T-cell infiltration into the tumor microenvironment.

Cancer research

Lesokhin AM, Hohl TM, Kitano S, Cortez C, Hirschhorn-Cymerman D, Avogadri F, Rizzuto GA, Lazarus JJ, Pamer EG, Houghton AN, Merghoub T, Wolchok JD

Detection of intra-tumor self antigen recognition during melanoma tumor progression in mice using advanced multimode confocal/two photon microscope.

PloS one

Schaer DA, Li Y, Merghoub T, Rizzuto GA, Shemesh A, Cohen AD, Li Y, Avogadri F, Toledo-Crow R, Houghton AN, Wolchok JD

Agonist anti-GITR monoclonal antibody induces melanoma tumor immunity in mice by altering regulatory T cell stability and intra-tumor accumulation.

PloS one

Cohen AD, Schaer DA, Liu C, Li Y, Hirschhorn-Cymmerman D, Kim SC, Diab A, Rizzuto G, Duan F, Perales MA, Merghoub T, Houghton AN, Wolchok JD

Cyclophosphamide enhances immunity by modulating the balance of dendritic cell subsets in lymphoid organs.


Nakahara T, Uchi H, Lesokhin AM, Avogadri F, Rizzuto GA, Hirschhorn-Cymerman D, Panageas KS, Merghoub T, Wolchok JD, Houghton AN

OX40 engagement and chemotherapy combination provides potent antitumor immunity with concomitant regulatory T cell apoptosis.

The Journal of experimental medicine

Hirschhorn-Cymerman D, Rizzuto GA, Merghoub T, Cohen AD, Avogadri F, Lesokhin AM, Weinberg AD, Wolchok JD, Houghton AN

Self-antigen-specific CD8+ T cell precursor frequency determines the quality of the antitumor immune response.

The Journal of experimental medicine

Rizzuto GA, Merghoub T, Hirschhorn-Cymerman D, Liu C, Lesokhin AM, Sahawneh D, Zhong H, Panageas KS, Perales MA, Altan-Bonnet G, Wolchok JD, Houghton AN

Improved tumor immunity using anti-tyrosinase related protein-1 monoclonal antibody combined with DNA vaccines in murine melanoma.

Cancer research

Saenger YM, Li Y, Chiou KC, Chan B, Rizzuto G, Terzulli SL, Merghoub T, Houghton AN, Wolchok JD

Tumor immunotherapy across MHC barriers using allogeneic T-cell precursors.

Nature biotechnology

Zakrzewski JL, Suh D, Markley JC, Smith OM, King C, Goldberg GL, Jenq R, Holland AM, Grubin J, Cabrera-Perez J, Brentjens RJ, Lu SX, Rizzuto G, Sant'Angelo DB, Riviere I, Sadelain M, Heller G, Zúñiga-Pflücker JC, Lu C, van den Brink MR

Mechanisms of immunization against cancer using chimeric antigens.

Molecular therapy : the journal of the American Society of Gene Therapy

Engelhorn ME, Guevara-Patiño JA, Merghoub T, Liu C, Ferrone CR, Rizzuto GA, Cymerman DH, Posnett DN, Houghton AN, Wolchok JD

344: Off-the-Shelf Tumor Immunotherapy with Genetically Enhanced Allogeneic T-Cell Precursors.

Biology of Blood and Marrow Transplantation

J.L. Zakrzewski, D. Suh, J.C. Markley, O.M. Smith, C. King, G. Goldberg, R. Jenq, A.M. Holland, J. Grubin, J. Cabrera-Perez, S.X. Lu, G. Rizzuto, D.B. Sant'Angelo, I. Riviere, M. Sadelain, J.C. Zuniga-Pflucker, M.R.M. van den Brink

Targeted ‘Off-the-Shelf’ Tumor Immunotherapy Using Allogeneic T-Cell Precursors.


Johannes L. Zakrzewski, David Suh, Odette M. Smith, Christopher King, Gabrielle L. Goldberg, Robert Jenq, Amanda M. Holland, Jeremy Grubin, Sydney X. Lu, Javier Cabrera-Perez, Gabrielle Rizzuto, Derek B. Sant’Angelo, Marcel R.M. van den Brink, John C. Markley, Isabelle Riviere, Michel Sadelain, Juan Carlos Zuniga-Pflucker

Agonist anti-GITR antibody induces CD8 T cell-mediated tumor rejection.

Journal of Clinical Oncology

A. D. Cohen, A. Diab, M. A. Perales, F. Duan, R. Jenq, G. Rizzuto, D. Hirschorn-Cymmerman, T. Merghoub, J. D. Wolchok, A. N. Houghton

Adoptive transfer of T-cell precursors enhances T-cell reconstitution after allogeneic hematopoietic stem cell transplantation.

Nature medicine

Zakrzewski JL, Kochman AA, Lu SX, Terwey TH, Kim TD, Hubbard VM, Muriglan SJ, Suh D, Smith OM, Grubin J, Patel N, Chow A, Cabrera-Perez J, Radhakrishnan R, Diab A, Perales MA, Rizzuto G, Menet E, Pamer EG, Heller G, Zúñiga-Pflücker JC, Alpdogan O, van den Brink MR

Agonist anti-GITR antibody enhances vaccine-induced CD8(+) T-cell responses and tumor immunity.

Cancer research

Cohen AD, Diab A, Perales MA, Wolchok JD, Rizzuto G, Merghoub T, Huggins D, Liu C, Turk MJ, Restifo NP, Sakaguchi S, Houghton AN

Optimization of a self antigen for presentation of multiple epitopes in cancer immunity.

The Journal of clinical investigation

Guevara-Patiño JA, Engelhorn ME, Turk MJ, Liu C, Duan F, Rizzuto G, Cohen AD, Merghoub T, Wolchok JD, Houghton AN

Unraveling the complex relationship between cancer immunity and autoimmunity: lessons from melanoma and vitiligo.

Advances in immunology

Uchi H, Stan R, Turk MJ, Engelhorn ME, Rizzuto GA, Goldberg SM, Wolchok JD, Houghton AN

Distinct CD4+-T-cell responses to live and heat-inactivated Aspergillus fumigatus conidia.

Infection and immunity

Rivera A, Van Epps HL, Hohl TM, Rizzuto G, Pamer EG


Journal of Experimental Medicine

Mary Jo Turk, José A. Guevara-Patiño, Gabrielle A. Rizzuto, Manuel E. Engelhorn, Shimon Sakaguchi, Alan N. Houghton

Concomitant tumor immunity to a poorly immunogenic melanoma is prevented by regulatory T cells.

The Journal of experimental medicine

Turk MJ, Guevara-Patiño JA, Rizzuto GA, Engelhorn ME, Sakaguchi S, Houghton AN

Novel HLA-A locus alleles including A*01012, A*0306, A*0308, A*2616, A*2617, A*3009, A*3206, A*3403, A*3602 and A*6604.

Tissue antigens

Bradshaw D, Gans CP, Jones P, Rizzuto G, Steiner N, Mitton W, Ng J, Koester R, Hartzman RJ, Hurley CK

Novel HLA-B alleles associated with antigens in the 7C CREG.

Tissue antigens

Steiner NK, Jones P, Kosman C, Edson S, Rizzuto G, Gans CP, Mitton W, Koester R, Rodriguez-Marino SG, Ng J, Hartzman RJ, Hurley CK

Twelve novel HLA-B*15 alleles carrying previously observed sequence motifs are placed into B*15 subgroups.

Tissue antigens

Hurley CK, Steiner N, Gans CP, Kosman C, Mitton W, Koester R, Jones P, Edson S, Rizzuto G, Hartzman RJ, Ng J, Rodriguez-Marino SG

Twenty-nine new HLA-B alleles associated with antigens in the 5C CREG.

Tissue antigens

Steiner NK, Kosman C, Jones PF, Gans CP, Rodriguez-Marino SG, Rizzuto G, Baldassarre LA, Edson S, Koester R, Sese D, Mitton W, Ng J, Hartzman RJ, Hurley CK

Novel HLA-B alleles associated with antigens in the 8C CREG.

Tissue antigens

Steiner NK, Gans CP, Kosman C, Baldassarre LA, Edson S, Jones PF, Rizzuto G, Pimtanothai N, Koester R, Mitton W, Ng J, Hartzman RJ, Hurley CK

Diversity of alleles encoding HLA-B40: relative frequencies in united states populations and description of five novel alleles.

Human immunology

Pimtanothai N, Rizzuto GA, Slack R, Steiner NK, Kosman CA, Jones PF, Koester R, Ng J, Hartzman RJ, Katovich Hurley C