Erin Gordon, MD

ASST PROFESSOR IN RESIDENCE
Medicine
+1 415 476-9456

I am a physician-scientist with an interest in airway epithelial dysfunction in asthma. Specifically, my lab focuses on understanding how genetic risk variants that are associated with asthma at a population level, actually confer risk of disease at a molecular level. We use novel techniques such as conditionally reprogrammed primary airway epithelial cells, CRISPR gene deletion, and biospecimens from large numbers of human subjects to discover the function of genes associated with asthma and elucidate the causal single nucleotide polymorphism. These efforts are designed to uncover novel drug targets and define the subpopulation of asthmatics most likely to benefit from therapy.

Publications: 

Interleukin-13 associated epithelial remodeling correlates with clinical severity in nasal polyposis.

The Journal of allergy and clinical immunology

Kotas ME, Patel NN, Cope EK, Gurrola JG, Goldberg AN, Pletcher SD, Seibold MA, Moore CM, Gordon ED

IL-13-programmed airway tuft cells produce PGE2, which promotes CFTR-dependent mucociliary function.

JCI insight

Kotas ME, Moore CM, Gurrola Ii JG, Pletcher SD, Goldberg AN, Alvarez R, Yamato S, Bratcher PE, Shaughnessy CA, Zeitlin PL, Zhang IH, Li Y, Montgomery MT, Lee K, Cope EK, Locksley RM, Seibold MA, Gordon ED

Lung Allograft Epithelium DNA Methylation Age Is Associated With Graft Chronologic Age and Primary Graft Dysfunction.

Frontiers in immunology

Dugger DT, Calabrese DR, Gao Y, Deiter F, Tsao T, Maheshwari J, Hays SR, Leard L, Kleinhenz ME, Shah R, Golden J, Kukreja J, Gordon ED, Singer JP, Greenland JR

Cystic Fibrosis Lung Transplant Recipients Have Suppressed Airway Interferon Responses during Pseudomonas Infection.

Cell reports. Medicine

Dugger DT, Fung M, Zlock L, Caldera S, Sharp L, Hays SR, Singer JP, Leard LE, Golden JA, Shah RJ, Kukreja J, Gordon E, Finkbeiner W, Kleinhenz ME, Langelier C, Greenland JR

Extracellular DNA, Neutrophil Extracellular Traps, and Inflammasome Activation in Severe Asthma.

American journal of respiratory and critical care medicine

Lachowicz-Scroggins ME, Dunican EM, Charbit AR, Raymond W, Looney MR, Peters MC, Gordon ED, Woodruff PG, Lefrançais E, Phillips BR, Mauger DT, Comhair SA, Erzurum SC, Johansson MW, Jarjour NN, Coverstone AM, Castro M, Hastie AT, Bleecker ER, Fajt ML, Wenzel SE, Israel E, Levy BD, Fahy JV

Cadherin-26 (CDH26) regulates airway epithelial cell cytoskeletal structure and polarity.

Cell discovery

Lachowicz-Scroggins ME, Gordon ED, Wesolowska-Andersen A, Jackson ND, MacLeod HJ, Sharp LZ, Sun M, Seibold MA, Fahy JV

Mucus plugs in patients with asthma linked to eosinophilia and airflow obstruction.

The Journal of clinical investigation

Dunican EM, Elicker BM, Gierada DS, Nagle SK, Schiebler ML, Newell JD, Raymond WW, Lachowicz-Scroggins ME, Di Maio S, Hoffman EA, Castro M, Fain SB, Jarjour NN, Israel E, Levy BD, Erzurum SC, Wenzel SE, Meyers DA, Bleecker ER, Phillips BR, Mauger DT, Gordon ED, Woodruff PG, Peters MC, Fahy JV, National Heart Lung and Blood Institute (NHLBI) Severe Asthma Research Program (SARP)

Corticosteroid and long-acting ß-agonist therapy reduces epithelial goblet cell metaplasia.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology

Lachowicz-Scroggins ME, Finkbeiner WE, Gordon ED, Yuan S, Zlock L, Bhakta NR, Woodruff PG, Fahy JV, Boushey HA

IL1RL1 asthma risk variants regulate airway type 2 inflammation.

JCI insight

Gordon ED, Palandra J, Wesolowska-Andersen A, Ringel L, Rios CL, Lachowicz-Scroggins ME, Sharp LZ, Everman JL, MacLeod HJ, Lee JW, Mason RJ, Matthay MA, Sheldon RT, Peters MC, Nocka KH, Fahy JV, Seibold MA

Alternative splicing of interleukin-33 and type 2 inflammation in asthma.

Proceedings of the National Academy of Sciences of the United States of America

Gordon ED, Simpson LJ, Rios CL, Ringel L, Lachowicz-Scroggins ME, Peters MC, Wesolowska-Andersen A, Gonzalez JR, MacLeod HJ, Christian LS, Yuan S, Barry L, Woodruff PG, Ansel KM, Nocka K, Seibold MA, Fahy JV

Cross-Talk between Epithelial Cells and Type 2 Immune Signaling. The Role of IL-25.

American journal of respiratory and critical care medicine

Gordon ED, Locksley RM, Fahy JV

Claudin-18 deficiency is associated with airway epithelial barrier dysfunction and asthma.

The Journal of allergy and clinical immunology

Sweerus K, Lachowicz-Scroggins M, Gordon E, LaFemina M, Huang X, Parikh M, Kanegai C, Fahy JV, Frank JA

98 Common genetic polymorphisms in the ST2 gene locus are associated with impaired soluble ST2 expression in the airway epithelium.

Cytokine

Erin D. Gordon, Cydney Urbanek, Shaopeng Yuan, Prescott Woodruff, John V. Fahy, Max A. Seibold

99 IL-33 splice variants are critical to its regulated secretion from airway epithelial cells.

Cytokine

Erin D. Gordon, Marrah Lachowicz-Scroggins, Cydney Urbanek, Max A. Seibold, John V. Fahy

A protective role for periostin and TGF-ß in IgE-mediated allergy and airway hyperresponsiveness.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology

Gordon ED, Sidhu SS, Wang ZE, Woodruff PG, Yuan S, Solon MC, Conway SJ, Huang X, Locksley RM, Fahy JV

Management of chronic obstructive pulmonary disease: moving beyond the asthma algorithm.

The Journal of allergy and clinical immunology

Gordon E, Lazarus SC

(R)-albuterol decreases immune responses: role of activated T cells.

Respiratory research

Ferrada MA, Gordon EL, Jen KY, He HZ, Lu X, Barone LM, Amirifeli S, Perkins DL, Finn PW