Elizabeth Crouch, MD, PhD

Assistant Adjunct Professor

I am a neuroscientist, a vascular biologist, and a physician in Neonatal-Perinatal medicine. My lab, the Neurovascular Development lab at crouchlab.ucsf.edu, studies how brain blood vessels grow and interact with other brain cells. In part, this interest is inspired from the preterm babies that I care for clinically. Approximately 20% of preterm babies born between 24-28 gestation weeks will develop germinal matrix hemorrhage (GMH). This hemorrhage can cause hydrocephalus, cerebral palsy, and death, and unfortunately there are currently no treatments. It remains unclear why vasculature in this developmental window is particularly sensitive. One critical barrier is the lack of a comprehensive understanding of the spatiotemporal dynamics of vascular cell development in the prenatal brain. Our research resolves around defining the stages of vascular stem cells in the developing brain and understanding the mechanisms that regulate their functions. We then apply this knowledge to produce novel technologies and therapeutic strategies for different brain hemorrhages in neonatal and pediatric patients. Towards these goals, we utilize neuropathological specimens, flow cytometry (FACS), bioinformatics, and cell culture, including organoid models. We are always interested in hiring motivated and talented individuals. Send an email to inquire; women and URM especially encouraged to apply. For fun, we run the BreakingDownBiology blog (also funded by UCSF ImmunoX) to explain exciting scientific journal articles with every day language. I also co-host "At the Bench: Neonatal Physician Scientists" for the Incubator Podcast network.


A Vascular-Centric Approach to Autism Spectrum Disorders.

Neuroscience insights

Ouellette J, Crouch EE, Morel JL, Coelho-Santos V, Lacoste B

Profiling human brain vascular cells using single-cell transcriptomics and organoids.

Nature protocols

Crouch EE, Diafos LN, Valenzuela EJ, Wedderburn-Pugh K, Birrueta JO, Caston J, Joseph T, Andrews MG, Bhaduri A, Huang EJ

Parents' Views on Autopsy, Organ Donation, and Research Donation After Neonatal Death.

JAMA network open

Crouch EE, Damas C, Bartrug WC, Shamiyeh A, Scelfo M, Dreyfus M, Gano D, Segal S, Franck LS

LIF signaling regulates outer radial glial to interneuron fate during human cortical development.

Cell stem cell

Andrews MG, Siebert C, Wang L, White ML, Ross J, Morales R, Donnay M, Bamfonga G, Mukhtar T, McKinney AA, Gemenes K, Wang S, Bi Q, Crouch EE, Parikshak N, Panagiotakos G, Huang E, Bhaduri A, Kriegstein AR

Meningeal solitary fibrous tumor cell states phenocopy cerebral vascular development and homeostasis.

Research square

Raleigh D, Mirchia K, Choudhury A, Joseph T, Birrueta J, Phillips J, Bhaduri A, Crouch E, Perry A

NOTCH3 drives meningioma tumorigenesis and resistance to radiotherapy.

bioRxiv : the preprint server for biology

Choudhury A, Cady MA, Lucas CG, Najem H, Phillips JJ, Palikuqi B, Zakimi N, Joseph T, Birrueta JO, Chen WC, Bush NAO, Hervey-Jumper SL, Klein OD, Toedebusch CM, Horbinski CM, Magill ST, Bhaduri A, Perry A, Dickinson PJ, Heimberger AB, Ashworth A, Crouch EE, Raleigh DR

Ensembles of endothelial and mural cells promote angiogenesis in prenatal human brain.


Crouch EE, Bhaduri A, Andrews MG, Cebrian-Silla A, Diafos LN, Birrueta JO, Wedderburn-Pugh K, Valenzuela EJ, Bennett NK, Eze UC, Sandoval-Espinosa C, Chen J, Mora C, Ross JM, Howard CE, Gonzalez-Granero S, Lozano JF, Vento M, Haeussler M, Paredes MF, Nakamura K, Garcia-Verdugo JM, Alvarez-Buylla A, Kriegstein AR, Huang EJ

Developmental dynamics of RNA translation in the human brain.

Nature neuroscience

Duffy EE, Finander B, Choi G, Carter AC, Pritisanac I, Alam A, Luria V, Karger A, Phu W, Sherman MA, Assad EG, Pajarillo N, Khitun A, Crouch EE, Ganesh S, Chen J, Berger B, Sestan N, O'Donnell-Luria A, Huang EJ, Griffith EC, Forman-Kay JD, Moses AM, Kalish BT, Greenberg ME

Tropism of SARS-CoV-2 for human cortical astrocytes.

Proceedings of the National Academy of Sciences of the United States of America

Andrews MG, Mukhtar T, Eze UC, Simoneau CR, Ross J, Parikshak N, Wang S, Zhou L, Koontz M, Velmeshev D, Siebert CV, Gemenes KM, Tabata T, Perez Y, Wang L, Mostajo-Radji MA, de Majo M, Donohue KC, Shin D, Salma J, Pollen AA, Nowakowski TJ, Ullian E, Kumar GR, Winkler EA, Crouch EE, Ott M, Kriegstein AR

Individual human cortical progenitors can produce excitatory and inhibitory neurons.


Delgado RN, Allen DE, Keefe MG, Mancia Leon WR, Ziffra RS, Crouch EE, Alvarez-Buylla A, Nowakowski TJ

The Expanding Cell Diversity of the Brain Vasculature.

Frontiers in physiology

Ross JM, Kim C, Allen D, Crouch EE, Narsinh K, Cooke DL, Abla AA, Nowakowski TJ, Winkler EA

Reciprocal Interaction between Vascular Filopodia and Neural Stem Cells Shapes Neurogenesis in the Ventral Telencephalon.

Cell reports

Di Marco B, Crouch EE, Shah B, Duman C, Paredes MF, Ruiz de Almodovar C, Huang EJ, Alfonso J

Outer Radial Glia-like Cancer Stem Cells Contribute to Heterogeneity of Glioblastoma.

Cell stem cell

Bhaduri A, Di Lullo E, Jung D, Müller S, Crouch EE, Espinosa CS, Ozawa T, Alvarado B, Spatazza J, Cadwell CR, Wilkins G, Velmeshev D, Liu SJ, Malatesta M, Andrews MG, Mostajo-Radji MA, Huang EJ, Nowakowski TJ, Lim DA, Diaz A, Raleigh DR, Kriegstein AR

Regional and stage-specific effects of prospectively purified vascular cells on the adult V-SVZ neural stem cell lineage.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Crouch EE, Liu C, Silva-Vargas V, Doetsch F

Novel association of early onset hepatocellular carcinoma with transaldolase deficiency.

JIMD reports

Leduc CA, Crouch EE, Wilson A, Lefkowitch J, Wamelink MM, Jakobs C, Salomons GS, Sun X, Shen Y, Chung WK

Adult neural stem cells and their niche: a dynamic duo during homeostasis, regeneration, and aging.

Current opinion in neurobiology

Silva-Vargas V, Crouch EE, Doetsch F

The ATM repair pathway inhibits RNA polymerase I transcription in response to chromosome breaks.


Kruhlak M, Crouch EE, Orlov M, Montaño C, Gorski SA, Nussenzweig A, Misteli T, Phair RD, Casellas R

Regulation of AID expression in the immune response.

The Journal of experimental medicine

Crouch EE, Li Z, Takizawa M, Fichtner-Feigl S, Gourzi P, Montaño C, Feigenbaum L, Wilson P, Janz S, Papavasiliou FN, Casellas R