Diana Alba, MD

Assistant Clinical Professor

Medicine

Diana Alba is an Assistant Professor of Medicine in the Division of Endocrinology at the University of California, San Francisco. As a physician-scientist, her research program is focused on identifying the transcriptional pathways that regulate adipose tissue function during normal development and obesity. Her work investigates how adipose tissue dysfunction, particularly through fibrotic remodeling, drives insulin resistance and metabolic dysfunction. By targeting these pathways, her lab aims to uncover novel therapeutic strategies to prevent or treat metabolic diseases through a deeper understanding of adipose tissue biology.

Publications:

PTP1B mediates the inhibitory effect of MFGE8 on insulin signaling through the β5 integrin.

The Journal of biological chemistry

Datta R, Mukherjee D, Podolsky MJ, Yang CD, Alba DL, Singh S, Arnold TD, Koliwad S, Lizama CO, Atabai K

Effects of Pharmacotherapy for the Treatment of Obesity in an Urban, Safety-Net Population.

Cureus

Kim EK, Hills NK, Cheng Z, Tucker C, Gutierrez M, Alba D, Murphy E, Kim S

MFGE8 inhibits insulin signaling through PTP1B.

bioRxiv : the preprint server for biology

Datta R, Podolsky MJ, Yang CD, Alba DL, Singh S, Koliwad S, Lizama CO, Atabai K

Autoantibodies to Perilipin-1 Define a Subset of Acquired Generalized Lipodystrophy.

Diabetes

Mandel-Brehm C, Vazquez SE, Liverman C, Cheng M, Quandt Z, Kung AF, Parent A, Miao B, Disse E, Cugnet-Anceau C, Dalle S, Orlova E, Frolova E, Alba D, Michels A, Oftedal BE, Lionakis MS, Husebye ES, Agarwal AK, Li X, Zhu C, Li Q, Oral E, Brown R, Anderson MS, Garg A, DeRisi JL

A gene-diet interaction controlling relative intake of dietary carbohydrates and fats.

Molecular metabolism

Nelson NG, Wu L, Maier MT, Lam D, Cheang R, Alba D, Huang A, Neumann DA, Hill T, Vagena E, Barsh GS, Medina MW, Krauss RM, Koliwad SK, Xu AW

Probing Insulin Sensitivity with Metabolically Competent Human Stem Cell-Derived White Adipose Tissue Microphysiological Systems.

Small (Weinheim an der Bergstrasse, Germany)

Qi L, Zushin PH, Chang CF, Lee YT, Alba DL, Koliwad SK, Stahl A

The East Asian gut microbiome is distinct from colocalized white subjects and connected to metabolic health.

eLife

Ang QY, Alba DL, Upadhyay V, Bisanz JE, Cai J, Lee HL, Barajas E, Wei G, Noecker C, Patterson AD, Koliwad SK, Turnbaugh PJ

CD81 Controls Beige Fat Progenitor Cell Growth and Energy Balance via FAK Signaling.

Cell

Oguri Y, Shinoda K, Kim H, Alba DL, Bolus WR, Wang Q, Brown Z, Pradhan RN, Tajima K, Yoneshiro T, Ikeda K, Chen Y, Cheang RT, Tsujino K, Kim CR, Greiner VJ, Datta R, Yang CD, Atabai K, McManus MT, Koliwad SK, Spiegelman BM, Kajimura S

Genetic basis for the cooperative bioactivation of plant lignans by Eggerthella lenta and other human gut bacteria.

Nature microbiology

Bess EN, Bisanz JE, Yarza F, Bustion A, Rich BE, Li X, Kitamura S, Waligurski E, Ang QY, Alba DL, Spanogiannopoulos P, Nayfach S, Koliwad SK, Wolan DW, Franke AA, Turnbaugh PJ

Elastase 3B mutation links to familial pancreatitis with diabetes and pancreatic adenocarcinoma.

The Journal of clinical investigation

Moore PC, Cortez JT, Chamberlain CE, Alba D, Berger AC, Quandt Z, Chan A, Cheng MH, Bautista JL, Peng J, German MS, Anderson MS, Oakes SA

Obesity and Fat Metabolism in Human Immunodeficiency Virus-Infected Individuals: Immunopathogenic Mechanisms and Clinical Implications.

The Journal of infectious diseases

Godfrey C, Bremer A, Alba D, Apovian C, Koethe JR, Koliwad S, Lewis D, Lo J, McComsey GA, Eckard A, Srinivasa S, Trevillyan J, Palmer C, Grinspoon S

Sweet cognition: The differential effects of glucose consumption on attentional food bias in individuals of lean and obese status.

Physiology & behavior

Mason AE, Jhaveri K, Schleicher S, Almeida C, Hartman A, Wackerly A, Alba D, Koliwad SK, Epel ES, Aschbacher K

Diana Alba, MD

PTP1B mediates the inhibitory effect of MFGE8 on insulin signaling through the β5 integrin.

Effects of Pharmacotherapy for the Treatment of Obesity in an Urban, Safety-Net Population.

MFGE8 inhibits insulin signaling through PTP1B.

Autoantibodies to Perilipin-1 Define a Subset of Acquired Generalized Lipodystrophy.

A gene-diet interaction controlling relative intake of dietary carbohydrates and fats.

Probing Insulin Sensitivity with Metabolically Competent Human Stem Cell-Derived White Adipose Tissue Microphysiological Systems.

The East Asian gut microbiome is distinct from colocalized white subjects and connected to metabolic health.

CD81 Controls Beige Fat Progenitor Cell Growth and Energy Balance via FAK Signaling.

Genetic basis for the cooperative bioactivation of plant lignans by Eggerthella lenta and other human gut bacteria.

Elastase 3B mutation links to familial pancreatitis with diabetes and pancreatic adenocarcinoma.

Obesity and Fat Metabolism in Human Immunodeficiency Virus-Infected Individuals: Immunopathogenic Mechanisms and Clinical Implications.

Sweet cognition: The differential effects of glucose consumption on attentional food bias in individuals of lean and obese status.

Changes in Lean Mass, Absolute and Relative Muscle Strength, and Physical Performance After Gastric Bypass Surgery.

Methadone-Associated Hypoglycemia in Chronic Renal Failure Masquerading as an Insulinoma.

Subcutaneous Fat Fibrosis Links Obesity to Insulin Resistance in Chinese Americans.

Repression of Adipose Tissue Fibrosis through a PRDM16-GTF2IRD1 Complex Improves Systemic Glucose Homeostasis.

Developmental staging of male murine embryonic gonad by SAGE analysis.

Application of transcriptional and biological network analyses in mouse germ-cell transcriptomes.

Transcriptome analyses of male germ cells with serial analysis of gene expression (SAGE).

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Diana Alba, MD