Carolyn Sangokoya, MD, PhD

Assistant Professor
carolyn.sangokoya AT

Carolyn Sangokoya, MD, PhD, is an Assistant Professor in the Department of Pathology at University of California, San Francisco.  Dr. Sangokoya completed her medical and graduate training as part of the Medical Scientist Training Program at Duke University, where she discovered roles for microRNAs in oxidative stress and cellular iron homeostasis during her graduate studies with Jen-Tsan Ashley Chi in the Duke University Program in Genetics and Genomics. At UCSF, she completed her post-graduate training in Anatomic Pathology, Surgical Pathology, and Gastrointestinal/Hepatobiliary Pathology through the Department of Pathology Physician-Scientist Pathway, and postdoctoral studies in stem cell and regenerative biology with Robert Blelloch at the Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, where she defined an axis of post-transcriptional control, endocytosis, and signal transduction essential for multiple aspects of stem cell biology.  Dr. Sangokoya is a recipient of the K08 Career Development Award from the NIH/NICHD to decipher post-transcriptional regulation of cell fate in early mammalian development. 

As a physician-scientist and board-certified pathologist, Dr. Sangokoya’s clinical interests are primarily in human liver pathobiology and diagnostics for precision-based medicine and regenerative therapies focused on non-alcoholic steatohepatitis (NASH), a leading cause of chronic liver disease and cirrhosis.  As a stem cell biologist, her basic science research interests are in dissecting the molecular networks that fine-tune the wiring and re-wiring of cell fates in mammalian stem cell-based models, leveraging genome engineering, quantitative cell biology, RNA sequencing, imaging, and cytometry at single-cell resolution.


Measuring Endocytosis and Endosomal Uptake at Single Cell Resolution.

Methods in molecular biology (Clifton, N.J.)

Sangokoya C

MicroRNA-dependent inhibition of PFN2 orchestrates ERK activation and pluripotent state transitions by regulating endocytosis.

Proceedings of the National Academy of Sciences of the United States of America

Sangokoya C, Blelloch R

Acidosis induces reprogramming of cellular metabolism to mitigate oxidative stress.

Cancer & metabolism

Lamonte G, Tang X, Chen JL, Wu J, Ding CK, Keenan MM, Sangokoya C, Kung HN, Ilkayeva O, Boros LG, Newgard CB, Chi JT

Isolation and characterization of microRNAs of human mature erythrocytes.

Methods in molecular biology (Clifton, N.J.)

Sangokoya C, LaMonte G, Chi JT

Look to behavioral economics.

Health affairs (Project Hope)

Sangokoya C