Arielle Klepper, MD, PhD

Clinical Fellow

AIH Therapy: Beyond First-Line.

Current Hepatology Reports

Irina Adao, Arielle Klepper, Michele Tana

Novel autoantibody targets identified in patients with autoimmune hepatitis (AIH) by PhIP-Seq reveals pathogenic insights.

medRxiv : the preprint server for health sciences

Klepper A, Kung A, Vazquez SE, Mitchell A, Mann S, Zorn K, Avila-Vargas I, Kari S, Tekeste M, Castro J, Lee B, Duarte M, Khalili M, Yang M, Wolters P, Price J, Perito E, Feng S, Maher JJ, Lai J, Weiler-Normann C, Lohse AW, DeRisi J, Tana M



Adam Blaisdell, Laurel Hochstetler, Arielle Klepper, Colin J. Feuille, Bing Zhang, Chelsea Q. Xu, Amy Yu, Amie Blanco, Jonathan P. Terdiman, Aparajita Singh

Transcriptomic profiling of blood from autoimmune hepatitis patients reveals potential mechanisms with implications for management.

PloS one

Tana MM, Klepper A, Lyden A, Pisco AO, Phelps M, McGee B, Green K, Feng S, DeRisi J, Crawford ED, Lammert CS

S305 Improving Identification of Patients Meeting Lynch Syndrome Testing Criteria in Endoscopy.

The American journal of gastroenterology

Adam Blaisdell, Laurel Hochstetler, Arielle Klepper, Colin Feuille, Bing Zhang, Amie Blanco, Jonathan Terdiman, Aparajita Singh

A subset of liver resident natural killer cells is expanded in hepatitis C-infected patients with better liver function.

Scientific reports

Doyle EH, Aloman C, El-Shamy A, Eng F, Rahman A, Klepper AL, Haydel B, Florman SS, Fiel MI, Schiano T, Branch AD

Individual liver plasmacytoid dendritic cells are capable of producing IFNa and multiple additional cytokines during chronic HCV infection.

PLoS pathogens

Doyle EH, Rahman A, Aloman C, Klepper AL, El-Shamy A, Eng F, Rocha C, Kim S, Haydel B, Florman SS, Fiel MI, Schiano T, Branch AD

Newly discovered hepatitis C virus minicores circulate in human blood.

Hepatology communications

Eng FJ, El-Shamy A, Doyle EH, Klepper A, Muerhoff AS, Branch AD

Hepatitis C virus double-stranded RNA is the predominant form in human liver and in interferon-treated cells.

Hepatology (Baltimore, Md.)

Klepper A, Eng FJ, Doyle EH, El-Shamy A, Rahman AH, Fiel MI, Avino GC, Lee M, Ye F, Roayaie S, Bansal MB, MacDonald MR, Schiano TD, Branch AD

A cell culture system for distinguishing hepatitis C viruses with and without liver cancer-related mutations in the viral core gene.

Journal of hepatology

El-Shamy A, Eng FJ, Doyle EH, Klepper AL, Sun X, Sangiovanni A, Iavarone M, Colombo M, Schwartz RE, Hoshida Y, Branch AD

Macrophages and the Viral Dissemination Super Highway.

EC microbiology

Klepper A, Branch AD

High mobility group box-1 (HMGB1) participates in the pathogenesis of alcoholic liver disease (ALD).

The Journal of biological chemistry

Ge X, Antoine DJ, Lu Y, Arriazu E, Leung TM, Klepper AL, Branch AD, Fiel MI, Nieto N

Sa1965 Hepatitis C Virus (HCV) Double-Stranded RNA is Abundant and May Be an Important Viral Reservoir in Persistence and Relapse.


Arielle L. Klepper, Francis J. Eng, James D. Dieterich, Jose Walewski, Julio A. Gutierrez, Myron E. Schwartz, Daniel S. Fierer, Thomas Schiano, Andrea D. Branch

Cross-genotypic polyclonal anti-HCV antibodies from human ascitic fluid.

Journal of virological methods

Gutierrez JA, Klepper AL, Garber J, Walewski JL, Bateman K, Khaitova V, Syder A, Tscherne DM, Gauthier A, Jefferson D, Rice CM, Schiano TD, Branch AD

Human peritoneal macrophages from ascitic fluid can be infected by a broad range of HIV-1 isolates.

Journal of acquired immune deficiency syndromes (1999)

Chang TL, Klepper A, Ding J, Garber J, Rapista A, Mosoian A, Hubner W, Gutierrez J, Walewski J, Abergel J, Schiano T, Branch A

Internal initiation stimulates production of p8 minicore, a member of a newly discovered family of hepatitis C virus core protein isoforms.

Journal of virology

Eng FJ, Walewski JL, Klepper AL, Fishman SL, Desai SM, McMullan LK, Evans MJ, Rice CM, Branch AD

Liver fibrosis during an outbreak of acute hepatitis C virus infection in HIV-infected men: a prospective cohort study.

The Journal of infectious diseases

Fierer DS, Uriel AJ, Carriero DC, Klepper A, Dieterich DT, Mullen MP, Thung SN, Fiel MI, Branch AD

Cox-2 is regulated by Toll-like receptor-4 (TLR4) signaling: Role in proliferation and apoptosis in the intestine.


Fukata M, Chen A, Klepper A, Krishnareddy S, Vamadevan AS, Thomas LS, Xu R, Inoue H, Arditi M, Dannenberg AJ, Abreu MT