Assoc Professor In Residence
M_MED-ZSFG-AIDS
My research focuses in applying novel epidemiological and statistical methods to understand the dynamics of infectious diseases and inform control interventions. While I am interested in infectious diseases generally, most of my work has focused on understanding shifts in the epidemiology of vector borne diseases including dengue, leishmaniasis, chikungunya, malaria and Zika.
Publications
Synchronized dynamics of dengue across the Americas.
Science translational medicine
Quantifying the role of importation on sustained malaria transmission in a low-to-moderate burden region of Southwest Uganda.
medRxiv : the preprint server for health sciences
Clone tracking through repeated malaria identifies high-fidelity memory CD4 T cell responses.
Science immunology
Strength and durability of indirect protection against SARS-CoV-2 infection through vaccine and infection-acquired immunity.
Nature communications
Reconciling heterogeneous dengue virus infection risk estimates from different study designs.
Proceedings of the National Academy of Sciences of the United States of America
Linking multiple serological assays to infer dengue virus infections from paired samples using mixture models.
medRxiv : the preprint server for health sciences
Gestational SARS-CoV-2 Infection in a Ugandan Birth Cohort: High Incidence, Mild Maternal Disease, and Evidence of Association with Transient Infant Stunting.
The American journal of tropical medicine and hygiene
Challenges and Approaches to Establishing Multi-Pathogen Serosurveillance: Findings from the 2023 Serosurveillance Summit.
The American journal of tropical medicine and hygiene
Dramatic resurgence of malaria after 7 years of intensive vector control interventions in Eastern Uganda.
PLOS Global Public Health
Dramatic resurgence of malaria after 7 years of intensive vector control interventions in Eastern Uganda.
medRxiv : the preprint server for health sciences
Household immunity and individual risk of infection with dengue virus in a prospective, longitudinal cohort study.
Nature microbiology
Maternally derived antibody titer dynamics and risk of hospitalized infant dengue disease.
Proceedings of the National Academy of Sciences of the United States of America
SARS-CoV-2 Serology Across Scales: A Framework for Unbiased Estimation of Cumulative Incidence Incorporating Antibody Kinetics and Epidemic Recency.
American journal of epidemiology
Metagenomic next-generation sequencing to characterize potential etiologies of non-malarial fever in a cohort living in a high malaria burden area of Uganda.
PLOS Global Public Health
Mapping malaria incidence using routine health facility surveillance data in Uganda.
BMJ global health
Malaria-driven expansion of adaptive-like functional CD56-negative NK cells correlates with clinical immunity to malaria.
Science translational medicine
Infectiousness of SARS-CoV-2 breakthrough infections and reinfections during the Omicron wave.
Nature medicine
East Africa International Center of Excellence for Malaria Research: Summary of Key Research Findings.
The American journal of tropical medicine and hygiene
Building an integrated serosurveillance platform to inform public health interventions: Insights from an experts' meeting on serum biomarkers.
PLoS neglected tropical diseases
Simulating the Impacts of Augmenting Intensive Vector Control with Mass Drug Administration or Test-and-Treat Strategies on the Malaria Infectious Reservoir.
The American journal of tropical medicine and hygiene
Resurgence of malaria in Uganda despite sustained indoor residual spraying and repeated long lasting insecticidal net distributions.
PLOS Global Public Health
Genetic variation that determines TAPBP expression levels associates with the course of malaria in an HLA allotype-dependent manner.
Proceedings of the National Academy of Sciences of the United States of America
Assessing the role of multiple mechanisms increasing the age of dengue cases in Thailand.
Proceedings of the National Academy of Sciences of the United States of America
Using sero-epidemiology to monitor disparities in vaccination and infection with SARS-CoV-2.
Nature communications
TNF-α+ CD4+ T cells dominate the SARS-CoV-2 specific T cell response in COVID-19 outpatients and are associated with durable antibodies.
Cell reports. Medicine
Beneath the surface: Amino acid variation underlying two decades of dengue virus antigenic dynamics in Bangkok, Thailand.
PLoS pathogens
COVID-19 Vaccination and Estimated Public Health Impact in California.
JAMA network open
Seroprevalence of anti-SARS-CoV-2 antibodies in Colombia, 2020: A population-based study.
Lancet Regional Health. Americas
Early immune responses have long-term associations with clinical, virologic, and immunologic outcomes in patients with COVID-19.
Research square
Persistence, Magnitude, and Patterns of Postacute Symptoms and Quality of Life Following Onset of SARS-CoV-2 Infection: Cohort Description and Approaches for Measurement.
Open forum infectious diseases
Age-Related Changes in Malaria Clinical Phenotypes During Infancy Are Modified by Sickle Cell Trait.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Using sero-epidemiology to monitor disparities in vaccination and infection with SARS-CoV-2.
medRxiv : the preprint server for health sciences
SARS-CoV-2 serology across scales: a framework for unbiased seroprevalence estimation incorporating antibody kinetics and epidemic recency.
medRxiv : the preprint server for health sciences
Trade-offs between individual and ensemble forecasts of an emerging infectious disease.
Nature communications
SARS-CoV-2 antibody magnitude and detectability are driven by disease severity, timing, and assay.
Science advances
Association of Inhibitory Killer Cell Immunoglobulin-like Receptor Ligands With Higher Plasmodium falciparum Parasite Prevalence.
The Journal of infectious diseases
Evaluation of the extended efficacy of the Dengvaxia vaccine against symptomatic and subclinical dengue infection.
Nature medicine
Sources of persistent malaria transmission in a setting with effective malaria control in eastern Uganda: a longitudinal, observational cohort study.
The Lancet. Infectious diseases
Citywide serosurveillance of the initial SARS-CoV-2 outbreak in San Francisco using electronic health records.
Nature communications
The impact of stopping and starting indoor residual spraying on malaria burden in Uganda.
Nature communications
Routine asymptomatic testing strategies for airline travel during the COVID-19 pandemic: a simulation study.
The Lancet. Infectious diseases
HLA Alleles B*53:01 and C*06:02 Are Associated With Higher Risk of P. falciparum Parasitemia in a Cohort in Uganda.
Frontiers in immunology
Rapid implementation of a cohort for the study of post-acute sequelae of SARS-CoV-2 infection/COVID-19.
medRxiv : the preprint server for health sciences
SARS-CoV-2 antibody magnitude and detectability are driven by disease severity, timing, and assay.
medRxiv : the preprint server for health sciences
Long-Term SARS-CoV-2-Specific Immune and Inflammatory Responses Across a Clinically Diverse Cohort of Individuals Recovering from COVID-19.
medRxiv : the preprint server for health sciences
Within-household clustering of genetically related Plasmodium falciparum infections in a moderate transmission area of Uganda.
Malaria journal
Routine asymptomatic testing strategies for airline travel during the COVID-19 pandemic: a simulation analysis.
medRxiv : the preprint server for health sciences
Estimating malaria incidence from routine health facility-based surveillance data in Uganda.
Malaria journal
Are Seroprevalence Estimates for Severe Acute Respiratory Syndrome Coronavirus 2 Biased?
The Journal of infectious diseases
Universal Polymerase Chain Reaction and Antibody Testing Demonstrate Little to No Transmission of Severe Acute Respiratory Syndrome Coronavirus 2 in a Rural Community.
Open forum infectious diseases
Malaria Transmission, Infection, and Disease following Sustained Indoor Residual Spraying of Insecticide in Tororo, Uganda.
The American journal of tropical medicine and hygiene
A systematic review of antibody mediated immunity to coronaviruses: kinetics, correlates of protection, and association with severity.
Nature communications
Heterogeneity of dengue transmission in an endemic area of Colombia.
PLoS neglected tropical diseases
Universal PCR and antibody testing demonstrate little to no transmission of SARS-CoV-2 in a rural community.
medRxiv : the preprint server for health sciences
Serology for SARS-CoV-2: Apprehensions, opportunities, and the path forward.
Science immunology
The Impact of Control Interventions on Malaria Burden in Young Children in a Historically High-Transmission District of Uganda: A Pooled Analysis of Cohort Studies from 2007 to 2018.
The American journal of tropical medicine and hygiene
A systematic review of antibody mediated immunity to coronaviruses: antibody kinetics, correlates of protection, and association of antibody responses with severity of disease.
medRxiv : the preprint server for health sciences
Rapid shifts in the age-specific burden of malaria following successful control interventions in four regions of Uganda.
Malaria journal
Mapping global variation in dengue transmission intensity.
Science translational medicine
Associations between red blood cell variants and malaria among children and adults from three areas of Uganda: a prospective cohort study.
Malaria journal
The Impact of Multiple Rounds of Indoor Residual Spraying on Malaria Incidence and Hemoglobin Levels in a High-Transmission Setting.
The Journal of infectious diseases
Impacts of Zika emergence in Latin America on endemic dengue transmission.
Nature communications
Pareto rules for malaria super-spreaders and super-spreading.
Nature communications
Serological inference of past primary and secondary dengue infection: implications for vaccination.
Journal of the Royal Society, Interface
Impact of Microscopic and Submicroscopic Parasitemia During Pregnancy on Placental Malaria in a High-Transmission Setting in Uganda.
The Journal of infectious diseases
Persistent Parasitemia Despite Dramatic Reduction in Malaria Incidence After 3 Rounds of Indoor Residual Spraying in Tororo, Uganda.
The Journal of infectious diseases
Long-term circulation of Zika virus in Thailand: an observational study.
The Lancet. Infectious diseases
Impact of preexisting dengue immunity on Zika virus emergence in a dengue endemic region.
Science (New York, N.Y.)
Dengue pre-vaccination screening and positive predictive values.
The Lancet. Infectious diseases
645: Revisiting the evidence underlying Zika travel restrictions: quantifying risk for pregnant travelers and their partners.
American Journal of Obstetrics and Gynecology
Heterogeneous exposure and hotspots for malaria vectors at three study sites in Uganda.
Gates open research
Taking Sharper Pictures of Malaria with CAMERAs: Combined Antibodies to Measure Exposure Recency Assays.
The American journal of tropical medicine and hygiene
Viridot: An automated virus plaque (immunofocus) counter for the measurement of serological neutralizing responses with application to dengue virus.
PLoS neglected tropical diseases
Dynamics and determinants of the force of infection of dengue virus from 1994 to 2015 in Managua, Nicaragua.
Proceedings of the National Academy of Sciences of the United States of America
Spatiotemporal incidence of Zika and associated environmental drivers for the 2015-2016 epidemic in Colombia.
Scientific data
Heterogeneous exposure and hotspots for malaria vectors at three study sites in Uganda.
Gates open research
High Hepatitis E Seroprevalence Among Displaced Persons in South Sudan.
The American journal of tropical medicine and hygiene
Impact of interventions and the incidence of ebola virus disease in Liberia-implications for future epidemics.
Health policy and planning
Impact of interventions and the incidence of ebola virus disease in Liberia-implications for future epidemics.
Health policy and planning
Benefits and risks of the Sanofi-Pasteur dengue vaccine: Modeling optimal deployment.
Science (New York, N.Y.)
Erratum to: Trends in the Mechanistic and Dynamic Modeling of Infectious Diseases.
Current Epidemiology Reports
Quantifying Heterogeneous Malaria Exposure and Clinical Protection in a Cohort of Ugandan Children.
The Journal of infectious diseases
Assessing the global threat from Zika virus.
Science (New York, N.Y.)
Trends in the Mechanistic and Dynamic Modeling of Infectious Diseases.
Current Epidemiology Reports
Predicting intensities of Zika infection and microcephaly using transmission intensities of other arboviruses.
Bulletin of the World Health Organization
Dengue Vaccine in Regions of Endemic Disease.
The New England journal of medicine
Chapter 18 Viral Epidemiology Tracking Viruses with Smartphones and Social Media.
Viral Pathogenesis
Dengue Virus (DENV) Neutralizing Antibody Kinetics in Children After Symptomatic Primary and Postprimary DENV Infection.
The Journal of infectious diseases
Enhancing disease surveillance with novel data streams: challenges and opportunities.
EPJ data science
Reconstruction of 60 Years of Chikungunya Epidemiology in the Philippines Demonstrates Episodic and Focal Transmission.
The Journal of infectious diseases
The Hidden Burden of Dengue and Chikungunya in Chennai, India.
PLoS neglected tropical diseases
Differential efficacy of dengue vaccine by immune status.
Lancet (London, England)
Estimating Potential Incidence of MERS-CoV Associated with Hajj Pilgrims to Saudi Arabia, 2014.
PLoS currents
Variability in dengue titer estimates from plaque reduction neutralization tests poses a challenge to epidemiological studies and vaccine development.
PLoS neglected tropical diseases
A review of transmission models of dengue: a quantitative and qualitative analysis of model features.
Dengue and dengue hemorrhagic fever
Revisiting Rayong: shifting seroprofiles of dengue in Thailand and their implications for transmission and control.
American journal of epidemiology
Challenges in the interpretation of dengue vaccine trial results.
PLoS neglected tropical diseases
Variation in dengue virus plaque reduction neutralization testing: systematic review and pooled analysis.
BMC infectious diseases
Noninferiority of miltefosine versus meglumine antimoniate for cutaneous leishmaniasis in children.
The Journal of infectious diseases
From re-emergence to hyperendemicity: the natural history of the dengue epidemic in Brazil.
PLoS neglected tropical diseases
Etiologic agent of an epidemic of cutaneous leishmaniasis in Tolima, Colombia.
The American journal of tropical medicine and hygiene