Assoc Professor In Residence
M_MED-ZSFG-EXPM
I am an infectious disease-trained Associate Professor of Medicine in the Division of Experimental Medicine at the University of California, San Francisco. My laboratory focuses on understanding the mechanisms that promote the formation of effective and durable CD8+ T cell immunity to viral pathogens (e.g., HIV, SARS-CoV-2) and vaccination at different stages of human development.
Publications
Cellular immune signatures associated with fast versus slow clearance of infectious SARS-CoV-2 4227.
The Journal of Immunology
CD38 expression by neonatal human naïve CD4 + T cells shapes their distinct metabolic state and tolerogenic potential.
bioRxiv : the preprint server for biology
Commensal myeloid crosstalk in neonatal skin regulates long-term cutaneous type 17 inflammation.
bioRxiv : the preprint server for biology
Circulating neutralizing antibodies and SARS-CoV-2 variant replication following postvaccination infections.
JCI insight
3.6 – 00159 Clinical and virologic outcomes of an art interruption in treated controllers and non-controllers.
Journal of virus eradication
Post-intervention control in HIV immunotherapy trials.
Current opinion in HIV and AIDS
Generating and measuring effective vaccine-elicited HIV-specific CD8+ T cell responses.
Current opinion in HIV and AIDS
PP 8.3 – 00049 Reduction in Markers of HIV Persistence with Gag/Pol/Il-12 DNA Therapeutic Vaccination.
Journal of virus eradication
Post-acute sequelae and adaptive immune responses in people living with HIV recovering from SARS-COV-2 infection.
AIDS (London, England)
CD8+ T-cell responses in HIV controllers: potential implications for novel HIV remission strategies.
Current opinion in HIV and AIDS
A cytotoxic-skewed immune set point predicts low neutralizing antibody levels after Zika virus infection.
Cell reports
HIV-specific CD8 T cells from elite controllers have an epigenetic imprint that preserves effector functions.
The Journal of Immunology
Pneumonia surveillance with culture-independent metatranscriptomics in HIV-positive adults in Uganda: a cross-sectional study.
The Lancet. Microbe
Persistence, Magnitude, and Patterns of Postacute Symptoms and Quality of Life Following Onset of SARS-CoV-2 Infection: Cohort Description and Approaches for Measurement.
Open forum infectious diseases
Impact of anti-PD-1 and anti-CTLA-4 on the HIV reservoir in people living with HIV with cancer on antiretroviral therapy: The AIDS Malignancy Consortium-095 study.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
SARS-CoV-2 Vaccination in the Context of Ongoing HIV Cure-Related Research Studies.
Journal of acquired immune deficiency syndromes (1999)
SARS-CoV-2 antibody magnitude and detectability are driven by disease severity, timing, and assay.
Science advances
Discordant Virus-Specific Antibody Levels, Antibody Neutralization Capacity, and T-cell Responses Following 3 Doses of SARS-CoV-2 Vaccination in a Patient With Connective Tissue Disease.
Open forum infectious diseases
Rapid implementation of a cohort for the study of post-acute sequelae of SARS-CoV-2 infection/COVID-19.
medRxiv : the preprint server for health sciences
Long-Term SARS-CoV-2-Specific Immune and Inflammatory Responses Across a Clinically Diverse Cohort of Individuals Recovering from COVID-19.
medRxiv : the preprint server for health sciences
Everolimus, an mTORC1/2 inhibitor, in ART-suppressed individuals who received solid organ transplantation: A prospective study.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Clinical Utility of Universal Broad-Range Polymerase Chain Reaction Amplicon Sequencing for Pathogen Identification: A Retrospective Cohort Study.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Beta cell-specific CD8+ T cells maintain stem cell memory-associated epigenetic programs during type 1 diabetes.
Nature immunology
A collaborative, multidisciplinary approach to HIV transmission risk mitigation during analytic treatment interruption.
Journal of virus eradication
OP 4.2 Characterising ‘exceptional’ control among HIV elite controllers.
Journal of virus eradication
Some Aspects of CD8+ T-Cell Exhaustion Are Associated With Altered T-Cell Mitochondrial Features and ROS Content in HIV Infection.
Journal of acquired immune deficiency syndromes (1999)
Rapid development of HIV elite control in a patient with acute infection.
BMC infectious diseases
Inconsistent HIV reservoir dynamics and immune responses following anti-PD-1 therapy in cancer patients with HIV infection.
Annals of oncology : official journal of the European Society for Medical Oncology
Early and Delayed Antiretroviral Therapy Results in Comparable Reductions in CD8+ T Cell Exhaustion Marker Expression.
AIDS research and human retroviruses
Disseminated Acanthamoeba infection in a heart transplant recipient treated successfully with a miltefosine-containing regimen: Case report and review of the literature.
Transplant infectious disease : an official journal of the Transplantation Society
Antimicrobial Resistance: A Call to Action!
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Broad-range PCR for early diagnosis of nosocomial Enterococcus gallinarum meningitis.
Infectious diseases (London, England)
Think global, act local: chronic dysuria and sterile pyuria in an Eritrean-American woman.
BMJ case reports
Differential localization of effector and memory CD8 T cell subsets in lymphoid organs during acute viral infection.
Journal of immunology (Baltimore, Md. : 1950)