Professor in Residence
M_Neurology
Publications
In cold blood: a new way to achieve therapeutic cooling?
Science bulletin
Use of Botulinum Toxin for Limb Immobilization for Rehabilitation in Rats with Experimental Stroke.
Biomolecules
Collateral Flow: Prolonging the Ischemic Penumbra.
Translational stroke research
Therapeutic hypothermia for stroke: Unique challenges at the bedside.
Frontiers in neurology
Sexual dimorphism in immune cell responses following stroke.
Neurobiology of disease
Cerebral small vessel disease alters neurovascular unit regulation of microcirculation integrity involved in vascular cognitive impairment.
Neurobiology of disease
Multimodal analysis of gene expression from postmortem brains and blood identifies synaptic vesicle trafficking genes to be associated with Parkinson's disease.
Briefings in bioinformatics
Fibrinogen is an Independent Risk Factor for White Matter Hyperintensities in CADASIL but not in Sporadic Cerebral Small Vessel Disease Patients.
Aging and disease
Clinical perspectives on ischemic stroke.
Experimental neurology
Cystatin C is a potential predictor of unfavorable outcomes for cerebral ischemia with intravenous tissue plasminogen activator treatment: A multicenter prospective nested case-control study.
European journal of neurology
Microglia, the brain's double agent.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
Heat Shock Protein 70 (HSP70) Induction: Chaperonotherapy for Neuroprotection after Brain Injury.
Cells
Heat shock protein signaling in brain ischemia and injury.
Neuroscience letters
Models of poststroke depression and assessments of core depressive symptoms in rodents: How to choose?
Experimental neurology
Therapeutic Hypothermia and Neuroprotection in Acute Neurological Disease.
Current medicinal chemistry
Triggering receptor expressed on myeloid cells-2 expression in the brain is required for maximal phagocytic activity and improved neurological outcomes following experimental stroke.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
Microglial Calcium Release-Activated Calcium Channel Inhibition Improves Outcome from Experimental Traumatic Brain Injury and Microglia-Induced Neuronal Death.
Journal of neurotrauma
Advances in Stroke 2017.
Stroke
The 70-kDa heat shock protein (Hsp70) as a therapeutic target for stroke.
Expert opinion on therapeutic targets
Anti-Inflammatory Targets for the Treatment of Reperfusion Injury in Stroke.
Frontiers in neurology
NOX Inhibitors - A Promising Avenue for Ischemic Stroke.
Experimental neurobiology
Hypothermia Identifies Dynamin as a Potential Therapeutic Target in Experimental Stroke.
Therapeutic hypothermia and temperature management
Activated complement protein C5a does not affect brain-derived endothelial cell viability and zonula occludens-1 levels following oxygen-glucose deprivation.
Brain circulation
70-kDa Heat Shock Protein Downregulates Dynamin in Experimental Stroke: A New Therapeutic Target?
Stroke
Postinjury Neuroplasticity in Central Neural Networks.
Neural plasticity
Triggering receptor expressed on myeloid cells 2 (TREM2) deficiency attenuates phagocytic activities of microglia and exacerbates ischemic damage in experimental stroke.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Inflammatory responses in brain ischemia.
Current medicinal chemistry
Mechanisms and potential therapeutic applications of microglial activation after brain injury.
CNS neuroscience & therapeutics
Pharmacological induction of the 70-kDa heat shock protein protects against brain injury.
Neuroscience
Calcium-sensing receptor (CaSR) as a novel target for ischemic neuroprotection.
Annals of clinical and translational neurology
The role of the microglia in acute CNS injury.
Metabolic brain disease
Innate inflammatory responses in stroke: mechanisms and potential therapeutic targets.
Current medicinal chemistry
Triggering Receptor Expressed on Myeloid Cells-2 Correlates to Hypothermic Neuroprotection in Ischemic Stroke.
Therapeutic hypothermia and temperature management
Influence of therapeutic hypothermia on regeneration after cerebral ischemia.
Frontiers of neurology and neuroscience
Hypothermia and pharmacological regimens that prevent overexpression and overactivity of the extracellular calcium-sensing receptor protect neurons against traumatic brain injury.
Journal of neurotrauma
The 70 kDa heat shock protein protects against experimental traumatic brain injury.
Neurobiology of disease
Mild hypothermia reduces tissue plasminogen activator-related hemorrhage and blood brain barrier disruption after experimental stroke.
Therapeutic hypothermia and temperature management
Sphingolipids in cardiovascular and cerebrovascular systems: Pathological implications and potential therapeutic targets.
World journal of cardiology
The immune modulating properties of the heat shock proteins after brain injury.
Anatomy & cell biology
Neuroprotection after cerebral ischemia.
Annals of the New York Academy of Sciences
Temperature affects thrombolytic efficacy using rt-Pa and eptifibatide, an in vitro study: editorial commentary on Meunier et al., 2012.
Therapeutic hypothermia and temperature management
Bone marrow chimeras in the study of experimental stroke.
Translational stroke research
NADPH oxidase in stroke and cerebrovascular disease.
Neurological research
Neuroprotective mechanisms of hypothermia in brain ischaemia.
Nature reviews. Neuroscience
NOX inhibitors as a therapeutic strategy for stroke and neurodegenerative disease.
Current drug targets
Therapeutic hypothermia in stroke.
Stroke research and treatment
Anti-inflammatory properties and pharmacological induction of Hsp70 after brain injury.
Inflammopharmacology
Hyperglycemia promotes tissue plasminogen activator-induced hemorrhage by Increasing superoxide production.
Annals of neurology
Significance of marrow-derived nicotinamide adenine dinucleotide phosphate oxidase in experimental ischemic stroke.
Annals of neurology
Brain 11: what's new in stroke research?
Expert review of neurotherapeutics
Therapeutic hypothermia after cardiac arrest: experience at an academically affiliated community-based veterans affairs medical center.
Stroke research and treatment
Mild Hypothermia Suppresses Calcium-Sensing Receptor (CaSR) Induction Following Forebrain Ischemia While Increasing GABA-B Receptor 1 (GABA-B-R1) Expression.
Translational stroke research
Endotoxin-activated microglia injure brain derived endothelial cells via NF-?B, JAK-STAT and JNK stress kinase pathways.
Journal of inflammation (London, England)
Direct protection of cultured neurons from ischemia-like injury by minocycline.
Anatomy & cell biology
Microglial activation in stroke: therapeutic targets.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics
Endogenous agmatine inhibits cerebral vascular matrix metalloproteinases expression by regulating activating transcription factor 3 and endothelial nitric oxide synthesis.
Current neurovascular research
Migraine and vertebrobasilar dissection: Case reports.
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association
Digitally quantifying cerebral hemorrhage using Photoshop and Image J.
Journal of neuroscience methods
Statins: multiple neuroprotective mechanisms in neurodegenerative diseases.
Experimental neurology
Alterations in 5-HT2A receptor binding in various brain regions among 6-hydroxydopamine-induced Parkinsonian rats.
Synapse (New York, N.Y.)
Hypothermia as a cytoprotective strategy in ischemic tissue injury.
Ageing research reviews
Does inflammation after stroke affect the developing brain differently than adult brain?
Developmental neuroscience
Pyruvate protects against experimental stroke via an anti-inflammatory mechanism.
Neurobiology of disease
Clinical application of therapeutic hypothermia in stroke.
Neurological research
A role for TREM2 ligands in the phagocytosis of apoptotic neuronal cells by microglia.
Journal of neurochemistry
Combination therapy with hypothermia for treatment of cerebral ischemia.
Journal of neurotrauma
Glucose and NADPH oxidase drive neuronal superoxide formation in stroke.
Annals of neurology
Inflammation and NFkappaB activation is decreased by hypothermia following global cerebral ischemia.
Neurobiology of disease
epsilonPKC confers acute tolerance to cerebral ischemic reperfusion injury.
Neuroscience letters
Chronic treatment with simvastatin upregulates muscarinic M1/4 receptor binding in the rat brain.
Neuroscience
FasL shedding is reduced by hypothermia in experimental stroke.
Journal of neurochemistry
Monitoring the protective effects of minocycline treatment with radiolabeled annexin V in an experimental model of focal cerebral ischemia.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
Conditions of protection by hypothermia and effects on apoptotic pathways in a rat model of permanent middle cerebral artery occlusion.
Journal of neurosurgery
Anti-inflammatory effects of the 70 kDa heat shock protein in experimental stroke.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
Subclinical embolization after carotid artery stenting: new lesions on diffusion-weighted magnetic resonance imaging occur postprocedure.
Journal of Vascular Surgery
Therapeutic hypothermia: neuroprotective mechanisms.
Frontiers in bioscience : a journal and virtual library
The inflammatory response in stroke.
Journal of neuroimmunology
INTRODUCTION: Immune mechanisms of neurodegeneration.
Clinical neuroscience research
Inflammation in adult and neonatal stroke.
Clinical neuroscience research
Effects of high dose of simvastatin on levels of dopamine and its reuptake in prefrontal cortex and striatum among SD rats.
Neuroscience letters
Influence of hypothermia on post-ischemic inflammation: role of nuclear factor kappa B (NFkappaB).
Neurochemistry international
99mTc-HYNIC-annexin V SPECT imaging of acute stroke and its response to neuroprotective therapy with anti-Fas ligand antibody.
European journal of nuclear medicine and molecular imaging
Therapeutic hypothermia for acute stroke.
International journal of stroke : official journal of the International Stroke Society
The application of HSP70 as a target for gene therapy.
Frontiers in bioscience : a journal and virtual library
Biphasic cytochrome c release after transient global ischemia and its inhibition by hypothermia.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
Antiapoptotic and anti-inflammatory mechanisms of heat-shock protein protection.
Annals of the New York Academy of Sciences
Reduction in levels of matrix metalloproteinases and increased expression of tissue inhibitor of metalloproteinase-2 in response to mild hypothermia therapy in experimental stroke.
Journal of neurosurgery
Gene therapy in neurological disease.
Methods in molecular medicine
Mild hypothermia decreases GSK3beta expression following global cerebral ischemia.
Neurocritical care
Post-ischemic inflammation: molecular mechanisms and therapeutic implications.
Neurological research
Agmatine reduces infarct area in a mouse model of transient focal cerebral ischemia and protects cultured neurons from ischemia-like injury.
Experimental neurology
Protein kinase C delta mediates cerebral reperfusion injury in vivo.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Chaperones, protein aggregation, and brain protection from hypoxic/ischemic injury.
The Journal of experimental biology
Glycogen synthase kinase 3beta inhibitor Chir025 reduces neuronal death resulting from oxygen-glucose deprivation, glutamate excitotoxicity, and cerebral ischemia.
Experimental neurology
Transplanted human fetal neural stem cells survive, migrate, and differentiate in ischemic rat cerebral cortex.
Proceedings of the National Academy of Sciences of the United States of America
Bcl-2 transfection via herpes simplex virus blocks apoptosis-inducing factor translocation after focal ischemia in the rat.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
Catalase over-expression protects striatal neurons from transient focal cerebral ischemia.
Neuroreport
Detection of focal hypoxic-ischemic injury and neuronal stress in a rodent model of unilateral MCA occlusion/reperfusion using radiolabeled annexin V.
European journal of nuclear medicine and molecular imaging
Many mechanisms for hsp70 protection from cerebral ischemia.
Journal of neurosurgical anesthesiology
Pathophysiology of acute ischemic stroke.
Cleveland Clinic journal of medicine
Cellular and molecular events underlying ischemia-induced neuronal apoptosis.
Drug news & perspectives
Attenuation of nitric oxide synthase isoform expression by mild hypothermia after focal cerebral ischemia: variations depending on timing of cooling.
Journal of neurosurgery
Stroke: molecular mechanisms and potential targets for treatment.
Current molecular medicine
Bcl-2 overexpression protects against neuron loss within the ischemic margin following experimental stroke and inhibits cytochrome c translocation and caspase-3 activity.
Journal of neurochemistry
Cellular targets of brain inflammation in stroke.
Current opinion in investigational drugs (London, England : 2000)
Gene therapy and hypothermia for stroke treatment.
Annals of the New York Academy of Sciences
Mild hypothermia inhibits nuclear factor-kappaB translocation in experimental stroke.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
Prospects for the treatment of stroke using gene therapy.
Expert review of neurotherapeutics
Effects of mild hypothermia on superoxide anion production, superoxide dismutase expression, and activity following transient focal cerebral ischemia.
Neurobiology of disease
Gene transfer of HSP72 protects cornu ammonis 1 region of the hippocampus neurons from global ischemia: influence of Bcl-2.
Annals of neurology
Use of diffusion weighted MRI to predict the occurrence and severity of hemorrhagic transformation in a rabbit model of embolic stroke.
Brain research
Influence of mild hypothermia on inducible nitric oxide synthase expression and reactive nitrogen production in experimental stroke and inflammation.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Heat shock proteins and neuroprotection.
Advances in experimental medicine and biology
Mild hypothermia attenuates cytochrome c release but does not alter Bcl-2 expression or caspase activation after experimental stroke.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
Mild hypothermia reduces apoptosis of mouse neurons in vitro early in the cascade.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
Neuroprotection: heat shock proteins.
Current medical research and opinion
Mild hypothermia increases Bcl-2 protein expression following global cerebral ischemia.
Brain research. Molecular brain research
Overexpression of HSP72 after induction of experimental stroke protects neurons from ischemic damage.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
Differential neuroprotection from human heat shock protein 70 overexpression in in vitro and in vivo models of ischemia and ischemia-like conditions.
Experimental neurology
Gene therapy for treatment of cerebral ischemia using defective herpes simplex viral vectors.
Neurological research
Gene therapy for treatment of cerebral ischemia using defective herpes simplex viral vectors.
Annals of the New York Academy of Sciences
Calbindin d28k overexpression protects striatal neurons from transient focal cerebral ischemia.
Stroke
Ischemic vulnerability of primary murine microglial cultures.
Neuroscience letters
Delayed induction and long-term effects of mild hypothermia in a focal model of transient cerebral ischemia: neurological outcome and infarct size.
Journal of neurosurgery
L-selectin inhibition does not reduce injury in a rabbit model of transient focal cerebral ischemia.
Neurological research
The neuroprotective potential of heat shock protein 70 (HSP70).
Molecular medicine today
A standardized MRI stroke protocol: comparison with CT in hyperacute intracerebral hemorrhage.
Stroke
Gene therapy with HSP72 is neuroprotective in rat models of stroke and epilepsy.
Annals of neurology
Hu23F2G, an antibody recognizing the leukocyte CD11/CD18 integrin, reduces injury in a rabbit model of transient focal cerebral ischemia.
Experimental neurology
Thrombolysis with reteplase, an unglycosylated plasminogen activator variant, in experimental embolic stroke.
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association
Editorial commentary.
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association
Dose escalation safety and tolerance study of the competitive NMDA antagonist selfotel (CGS 19755) in neurosurgery patients.
Clinical neuropharmacology
SNX-111, a novel, presynaptic N-type calcium channel antagonist, is neuroprotective against focal cerebral ischemia in rabbits.
Journal of the neurological sciences
Diffusion-weighted magnetic resonance imaging characteristics of hemorrhagic transformation in experimental embolic stroke.
Journal of neuroimaging : official journal of the American Society of Neuroimaging
Improved perfusion with rt-PA and hirulog in a rabbit model of embolic stroke.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
Intravenous thrombolytic therapy in acute stroke.
Vascular medicine (London, England)
Dose escalation safety and tolerance study of the N-methyl-D-aspartate antagonist dextromethorphan in neurosurgery patients.
Journal of neurosurgery
Clinical aspects of DWI.
NMR in biomedicine
Thrombolysis with tissue plasminogen activator (tPA) is temperature dependent.
Thrombosis research