Lucy Kornblith, MD

Assoc Professor in Residence
M_Surgery
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Lucy Zumwinkle Kornblith, M.D., F.A.C.S. received her undergraduate degree from University of California Santa Barbara, her M.D. from the University of Colorado, completed her General Surgery residency at the University of California San Francisco (UCSF), a Trauma and Critical Care Clinical Translational Research Fellowship at UCSF, and subspecialty training in Trauma and Acute Care Surgery and Surgical Critical Care at UCSF prior to joining the faculty at UCSF. She clinically practices Trauma Surgery, Acute Care Surgery, and Surgical Critical Care. She has played a pivotal role in the translational study of blood system failure after injury, centrally focused on post-injury platelet biology. Her research program is multi-pronged, covering 1) Translational research to identify novel biology of blood system failure through the lens of platelets, 2) Large observational studies to identify predictors of bad outcomes after injury, and 3) Clinical trials investigating therapeutics and resuscitation strategies for injured patients. Her research program has been funded by the National Institutes of Health, the Department of Defense, the American College of Surgeons, the Eastern Association for the Surgery of Trauma, the UCSF School of Medicine Irene Perstein Award, and the Doris Duke Charitable Foundation. Dr. Kornblith is the Department of Surgery Director of Gender Equity and a co-chair of the UCSF Department of Surgery Muriel Steele Society, an inclusive community dedicated to inspiring, supporting, and promoting 400+ women surgeons so they can thrive at all stages of their careers.

Publications

Treatment with Allogenic Mesenchymal Stromal Cells for Moderate to Severe Acute Respiratory Distress Syndrome: A Double-Blind, Placebo-controlled, Multi-Center, Phase 2b Clinical Trial (STAT).

American journal of respiratory and critical care medicine

Matthay MA, Zhou H, Sarma A, Alipanah-Lechner N, Hendrickson C, Kornblith LZ, Schreiber M, Zonies D, Khan A, Robinson B, Johnson NJ, Ware LB, Guillamondegui O, Casey J, Moore L, Patel B, Kao L, Wade CE, Fox E, Cox C, Khawanja F, Aguillon Prada R, Hossri S, Callcut R, Albertson T, Delucchi KL, McMillan M, Langelier CR, Pati S, McKenna DH, Leroux C, Calfee CS, Liu KD

Effect of sodium-glucose co-transporter-2 inhibitors on survival free of organ support in patients hospitalised for COVID-19 (ACTIV-4a): a pragmatic, multicentre, open-label, randomised, controlled, platform trial.

The lancet. Diabetes & endocrinology

Kosiborod MN, Windsor SL, Vardeny O, Berger JS, Reynolds HR, Boumakis S, Althouse AD, Solomon SD, Bhatt AS, Peikert A, Luther JF, Leifer ES, Kindzelski AL, Cushman M, Ng Gong M, Kornblith LZ, Khatri P, Kim KS, Baumann Kreuziger L, Javaheri A, Carpio C, Wahid L, Lopez-Sendon Moreno J, Alonso A, Ho MQ, Lopez-Sendon J, Lopes RD, Curtis JL, Kirwan BA, Geraci MW, Neal MD, Hochman JS, ACTIV-4a Investigators

Platelet releasates mitigate the endotheliopathy of trauma.

The journal of trauma and acute care surgery

Gallagher LT, LaCroix I, Fields AT, Mitra S, Argabright A, D'Alessandro A, Erickson C, Nunez-Garcia B, Herrera-Rodriguez K, Chou YC, Stocker BW, Ramser BJ, Thielen O, Hallas W, Siliiman CC, Kornblith LZ, Cohen MJ

Early Cold Stored Platelet Transfusion Following Severe Injury: A Randomized Clinical Trial.

Annals of surgery

Sperry JL, Guyette FX, Rosario-Rivera BL, Kutcher ME, Kornblith LZ, Cotton BA, Wilson CT, Inaba K, Zadorozny EV, Vincent LE, Harner AM, Love ET, Doherty JE, Cuschieri J, Kornblith AE, Fox EE, Bai Y, Hoffman MK, Seger CP, Hudgins J, Mallett-Smith S, Neal MD, Leeper CM, Spinella PC, Yazer MH, Wisniewski SR, Cold Stored Platelet for Hemorrhagic Shock (CRISP-HS) study group

Heparin Dose Intensity and Organ Support-Free Days in Patients Hospitalized for COVID-19.

JACC. Advances

Godoy LC, Neal MD, Goligher EC, Cushman M, Houston BL, Bradbury CA, McQuilten ZK, Tritschler T, Kahn SR, Berry LR, Lorenzi E, Jensen T, Higgins AM, Kornblith LZ, Berger JS, Gong MN, Paul JD, Castellucci LA, Le Gal G, Lother SA, Rosenson RS, Derde LPG, Kumar A, McVerry BJ, Nicolau JC, Leifer E, Escobedo J, Huang DT, Reynolds HR, Carrier M, Kim KS, Hunt BJ, Slutsky AS, Turgeon AF, Webb SA, McArthur CJ, Farkouh ME, Hochman JS, Zarychanski R, Lawler PR

Abstract 13200: Changes in Thrombi-Inflammatory Biomarkers Associated With Therapeutic Heparin in Non-Critically Ill Patients Hospitalized With COVID-19: A Pre-Specified Secondary Analysis of the ACTIV4a and ATTACC Randomized Clinical Trial.

Circulation

Lana Wahid, Joshua Froess, Thomas L Ortel, Ryan Zarychanski, Michelle N Gong, Mary Cushman, Lucy Kornblith, Lana Castellucci, Michael E Farkouh, Ewan Gologher, Bryan J McVerry, Grant V Bochicchio, Abhijit Duggal, Yonatan Greenstein, Nicholas Hanna, Kristin Hudock, David T Huang, Robert Hyzy, Akram Khan, Vidya Krishnan, Matthew Kutcher, George Lim, Jose Luis Lopez-Sendon Moreno, Michael A Matthay, Ambarish Pandey, John Quigley, Lewis Satterwhite, Robert J Widmer, Jenny Jenny Wilson, Judith S Hochman, Jeffrey S Berger, Matthew D Neal, Patrick R Lawler

Abstract 14153: P2Y12 Inhibitors and Quality of Life Outcomes in Critically Ill Patients Hospitalized for COVID-19: A Pre-Specified Secondary Analysis of the ACTIV4a Randomized Clinical Trial.

Circulation

Lana Wahid, Erinn M Hade, Mary Cushman, Michelle N Gong, Valerie Renard, Emily R Ko, Tatyana Der, Lucy Z Kornblith, Patrick R Lawler, Harmony Reynolds, Chowdhury Ahsan, Grant Bochicchio, Carlos Carpio, Nicholas Hanna, Kristin Hudock, Robert Hyzy, Fatima Ibanez Estellez, Nicole Iovine, George Lim, Jose Luis Lopez-Sendon Moreno, Jorge Moises, jesus peteiro, John G Quigley, FERNANDO WORNER, Mikhail N Kosiborod, Scott D Solomon, Matthew D Neal, Judith S Hochman, Jeffrey S Berger

Effect of P2Y12 Inhibitors on Organ Support-Free Survival in Critically Ill Patients Hospitalized for COVID-19: A Randomized Clinical Trial.

JAMA network open

Berger JS, Neal MD, Kornblith LZ, Gong MN, Reynolds HR, Cushman M, Althouse AD, Lawler PR, McVerry BJ, Kim KS, Baumann Kreuziger L, Solomon SD, Kosiborod MN, Berry SM, Bochicchio GV, Contoli M, Farkouh ME, Froess JD, Gandotra S, Greenstein Y, Hade EM, Hanna N, Hudock K, Hyzy RC, Ibáñez Estéllez F, Iovine N, Khanna AK, Khatri P, Kirwan BA, Kutcher ME, Leifer E, Lim G, Lopes RD, Lopez-Sendon JL, Luther JF, Nigro Maia L, Quigley JG, Wahid L, Wilson JG, Zarychanski R, Kindzelski A, Geraci MW, Hochman JS, ACTIV-4a Investigators

Prehospital End Tidal Carbon Dioxide is Predictive of Death and Massive Transfusion in Injured Patients: An EAST Multicenter Trial.

The journal of trauma and acute care surgery

Campion EM, Cralley A, Sauaia A, Buchheit RC, Brown AT, Spalding MC, LaRiccia A, Moore S, Tann K, Leskovan J, Camazine M, Barnes SL, Otaibi B, Hazelton JP, Jacobson LE, Williams J, Castillo R, Stewart NJ, Elterman JB, Zier L, Goodman M, Elson N, Miner J, Hardman C, Kapoen C, Mendoza AE, Schellenberg M, Benjamin E, Wakam GK, Alam HB, Kornblith LZ, Callcut RA, Coleman LE, Shatz DV, Burruss S, Linn AC, Perea L, Morgan M, Schroeppel TJ, Stillman Z, Carrick MM, Gomez MF, Berne JD, McIntyre RC, Urban S, Nahmias J, Tay E, Cohen M, Moore EE, McVaney K, Burlew CC

Effect of P2Y12 Inhibitors on Survival Free of Organ Support Among Non-Critically Ill Hospitalized Patients With COVID-19: A Randomized Clinical Trial.

JAMA

Berger JS, Kornblith LZ, Gong MN, Reynolds HR, Cushman M, Cheng Y, McVerry BJ, Kim KS, Lopes RD, Atassi B, Berry S, Bochicchio G, de Oliveira Antunes M, Farkouh ME, Greenstein Y, Hade EM, Hudock K, Hyzy R, Khatri P, Kindzelski A, Kirwan BA, Baumann Kreuziger L, Lawler PR, Leifer E, Lopez-Sendon Moreno J, Lopez-Sendon J, Luther JF, Nigro Maia L, Quigley J, Sherwin R, Wahid L, Wilson J, Hochman JS, Neal MD, ACTIV-4a Investigators

Platelets amplify endotheliopathy in COVID-19.

Science advances

Barrett TJ, Cornwell M, Myndzar K, Rolling CC, Xia Y, Drenkova K, Biebuyck A, Fields AT, Tawil M, Luttrell-Williams E, Yuriditsky E, Smith G, Cotzia P, Neal MD, Kornblith LZ, Pittaluga S, Rapkiewicz AV, Burgess HM, Mohr I, Stapleford KA, Voora D, Ruggles K, Hochman J, Berger JS

Abstract 109: Platelets Amplify Endotheliopathy In Covid-19.

Arteriosclerosis Thrombosis and Vascular Biology

Tessa J Barrett, MacIntosh Cornwell, Khrystyna Myndzar, Christina Rolling, Yuhe Xia, Kamelia Drenkova, Antoine Biebuyck, Alexander Fields, Michael Tawil, Elliot Luttrell-Williams, Eugene Yuriditsky, Grace Smith, Paolo Cotzia, Matthew D Neal, Lucy Kornblith, Stefania Pittaluga, Amy Rapkiewicz, Hannah Burgess, Ian Mohr, Kenneth Stapleford, Deepak Voora, Kelly Ruggles, Judith Hochman, Jeffrey S Berger

Therapeutic Anticoagulation with Heparin in Critically Ill Patients with Covid-19.

The New England journal of medicine

REMAP-CAP Investigators , ACTIV-4a Investigators , ATTACC Investigators , Goligher EC, Bradbury CA, McVerry BJ, Lawler PR, Berger JS, Gong MN, Carrier M, Reynolds HR, Kumar A, Turgeon AF, Kornblith LZ, Kahn SR, Marshall JC, Kim KS, Houston BL, Derde LPG, Cushman M, Tritschler T, Angus DC, Godoy LC, McQuilten Z, Kirwan BA, Farkouh ME, Brooks MM, Lewis RJ, Berry LR, Lorenzi E, Gordon AC, Berry SM, McArthur CJ, Neal MD, Hochman JS, Webb SA, Zarychanski R, Ahuja T, Al-Beidh F, Annane D, Arabi YM, Aryal D, Baumann Kreuziger L, Beane A, Bhimani Z, Bihari S, Billett HH, Bond L, Bonten M, Brunkhorst F, Buxton M, Buzgau A, Castellucci LA, Chekuri S, Chen JT, Cheng AC, Chkhikvadze T, Coiffard B, Contreras A, Costantini TW, de Brouwer S, Detry MA, Duggal A, Džavík V, Effron MB, Eng HF, Escobedo J, Estcourt LJ, Everett BM, Fergusson DA, Fitzgerald M, Fowler RA, Froess JD, Fu Z, Galanaud JP, Galen BT, Gandotra S, Girard TD, Goodman AL, Goossens H, Green C, Greenstein YY, Gross PL, Haniffa R, Hegde SM, Hendrickson CM, Higgins AM, Hindenburg AA, Hope AA, Horowitz JM, Horvat CM, Huang DT, Hudock K, Hunt BJ, Husain M, Hyzy RC, Jacobson JR, Jayakumar D, Keller NM, Khan A, Kim Y, Kindzelski A, King AJ, Knudson MM, Kornblith AE, Kutcher ME, Laffan MA, Lamontagne F, Le Gal G, Leeper CM, Leifer ES, Lim G, Gallego Lima F, Linstrum K, Litton E, Lopez-Sendon J, Lother SA, Marten N, Saud Marinez A, Martinez M, Mateos Garcia E, Mavromichalis S, McAuley DF, McDonald EG, McGlothlin A, McGuinness SP, Middeldorp S, Montgomery SK, Mouncey PR, Murthy S, Nair GB, Nair R, Nichol AD, Nicolau JC, Nunez-Garcia B, Park JJ, Park PK, Parke RL, Parker JC, Parnia S, Paul JD, Pompilio M, Quigley JG, Rosenson RS, Rost NS, Rowan K, Santos FO, Santos M, Santos MO, Satterwhite L, Saunders CT, Schreiber J, Schutgens REG, Seymour CW, Siegal DM, Silva DG, Singhal AB, Slutsky AS, Solvason D, Stanworth SJ, Turner AM, van Bentum-Puijk W, van de Veerdonk FL, van Diepen S, Vazquez-Grande G, Wahid L, Wareham V, Widmer RJ, Wilson JG, Yuriditsky E, Zhong Y

Therapeutic Anticoagulation with Heparin in Noncritically Ill Patients with Covid-19.

The New England journal of medicine

ATTACC Investigators , ACTIV-4a Investigators , REMAP-CAP Investigators , Lawler PR, Goligher EC, Berger JS, Neal MD, McVerry BJ, Nicolau JC, Gong MN, Carrier M, Rosenson RS, Reynolds HR, Turgeon AF, Escobedo J, Huang DT, Bradbury CA, Houston BL, Kornblith LZ, Kumar A, Kahn SR, Cushman M, McQuilten Z, Slutsky AS, Kim KS, Gordon AC, Kirwan BA, Brooks MM, Higgins AM, Lewis RJ, Lorenzi E, Berry SM, Berry LR, Angus DC, McArthur CJ, Webb SA, Farkouh ME, Hochman JS, Zarychanski R, Aday AW, Al-Beidh F, Annane D, Arabi YM, Aryal D, Baumann Kreuziger L, Beane A, Bhimani Z, Bihari S, Billett HH, Bond L, Bonten M, Brunkhorst F, Buxton M, Buzgau A, Castellucci LA, Chekuri S, Chen JT, Cheng AC, Chkhikvadze T, Coiffard B, Costantini TW, de Brouwer S, Derde LPG, Detry MA, Duggal A, Džavík V, Effron MB, Estcourt LJ, Everett BM, Fergusson DA, Fitzgerald M, Fowler RA, Galanaud JP, Galen BT, Gandotra S, García-Madrona S, Girard TD, Godoy LC, Goodman AL, Goossens H, Green C, Greenstein YY, Gross PL, Hamburg NM, Haniffa R, Hanna G, Hanna N, Hegde SM, Hendrickson CM, Hite RD, Hindenburg AA, Hope AA, Horowitz JM, Horvat CM, Hudock K, Hunt BJ, Husain M, Hyzy RC, Iyer VN, Jacobson JR, Jayakumar D, Keller NM, Khan A, Kim Y, Kindzelski AL, King AJ, Knudson MM, Kornblith AE, Krishnan V, Kutcher ME, Laffan MA, Lamontagne F, Le Gal G, Leeper CM, Leifer ES, Lim G, Lima FG, Linstrum K, Litton E, Lopez-Sendon J, Lopez-Sendon Moreno JL, Lother SA, Malhotra S, Marcos M, Saud Marinez A, Marshall JC, Marten N, Matthay MA, McAuley DF, McDonald EG, McGlothlin A, McGuinness SP, Middeldorp S, Montgomery SK, Moore SC, Morillo Guerrero R, Mouncey PR, Murthy S, Nair GB, Nair R, Nichol AD, Nunez-Garcia B, Pandey A, Park PK, Parke RL, Parker JC, Parnia S, Paul JD, Pérez González YS, Pompilio M, Prekker ME, Quigley JG, Rost NS, Rowan K, Santos FO, Santos M, Olombrada Santos M, Satterwhite L, Saunders CT, Schutgens REG, Seymour CW, Siegal DM, Silva DG, Shankar-Hari M, Sheehan JP, Singhal AB, Solvason D, Stanworth SJ, Tritschler T, Turner AM, van Bentum-Puijk W, van de Veerdonk FL, van Diepen S, Vazquez-Grande G, Wahid L, Wareham V, Wells BJ, Widmer RJ, Wilson JG, Yuriditsky E, Zampieri FG

Outcomes after ultramassive transfusion in the modern era: An Eastern Association for the Surgery of Trauma multicenter study.

The journal of trauma and acute care surgery

Matthay ZA, Hellmann ZJ, Callcut RA, Matthay EC, Nunez-Garcia B, Duong W, Nahmias J, LaRiccia AK, Spalding MC, Dalavayi SS, Reynolds JK, Lesch H, Wong YM, Chipman AM, Kozar RA, Penaloza L, Mukherjee K, Taghlabi K, Guidry CA, Seng SS, Ratnasekera A, Motameni A, Udekwu P, Madden K, Moore SA, Kirsch J, Goddard J, Haan J, Lightwine K, Ontengco JB, Cullinane DC, Spitzer SA, Kubasiak JC, Gish J, Hazelton JP, Byskosh AZ, Posluszny JA, Ross EE, Park JJ, Robinson B, Abel MK, Fields AT, Esensten JH, Nambiar A, Moore J, Hardman C, Terse P, Luo-Owen X, Stiles A, Pearce B, Tann K, Abdul Jawad K, Ruiz G, Kornblith LZ

Trauma-induced coagulopathy.

Nature reviews. Disease primers

Moore EE, Moore HB, Kornblith LZ, Neal MD, Hoffman M, Mutch NJ, Schöchl H, Hunt BJ, Sauaia A

Platelets.

Zachary A. Matthay, Lucy Zumwinkle Kornblith

The why and how our trauma patients die: A prospective Multicenter Western Trauma Association study.

The journal of trauma and acute care surgery

Callcut RA, Kornblith LZ, Conroy AS, Robles AJ, Meizoso JP, Namias N, Meyer DE, Haymaker A, Truitt MS, Agrawal V, Haan JM, Lightwine KL, Porter JM, San Roman JL, Biffl WL, Hayashi MS, Sise MJ, Badiee J, Recinos G, Inaba K, Schroeppel TJ, Callaghan E, Dunn JA, Godin S, McIntyre RC, Peltz ED, O'Neill PJ, Diven CF, Scifres AM, Switzer EE, West MA, Storrs S, Cullinane DC, Cordova JF, Moore EE, Moore HB, Privette AR, Eriksson EA, Cohen MJ, Western Trauma Association Multicenter Study Group

The found down patient: A Western Trauma Association multicenter study.

The journal of trauma and acute care surgery

Howard BM, Kornblith LZ, Conroy AS, Burlew CC, Wagenaar AE, Chouliaras K, Hill JR, Carrick MM, Mallory GR, Watkins JR, Truitt MS, Ciesla DJ, Davis JA, Vail CJ, Kemp Bohan PM, Nelson MF, Callcut RA, Cohen MJ, Western Trauma Association Multicenter Study Group

Untitled Publication

Diane A. Schwartz, Lucy Z. Kornblith, John B. Holcomb, Mitchell Jay Cohen. “Chapter 128. Multitrauma Derangement in Hemostasis and Thrombosis.” In: Marder et al: Hemostasis and Thrombosis: Basic Principles and Clinical Practice, 6th eds. 2013.

Untitled Publication

Rochelle Dicker, Lucy Z. Kornblith. “Chapter 26. Acute Abdominal Pain.” In: Vincent et al: Textbook of Critical Care, 7th eds. 2017.

Untitled Publication

Anamaria J. Robles, Lucy Z. Kornblith. “Coagulopathy in Trauma”. In: Dynamed Plus, 2017.

Untitled Publication

Zachary Matthay, Lucy Z. Kornblith. “Platelets.” In: Trauma Induced Coagulopathy, 2nd eds. 2019.