Kelly Wentworth, MD

Asst Professor in Residence

M_MED-VAMC-ENDO-ENDO

My research focuses on understanding the role of Gs-protein coupled receptor signaling in skeletal development, with a focused interest in craniofacial fibrous dysplasia of the bone (FD) and McCune-Albright syndrome (MAS).

Publications

Single-cell analysis of human fibrous dysplasia bone reveals a fibrotic transcriptome and GNAS variants in endothelial, perivascular, and stromal cells.

American journal of human genetics

Wentworth KL, Fierro FA, Moody TA, Le B, Michel Z, Boyce A, Collins M, Kram V, de Castro LF, Chow ED, Qorbani A, Hsiao EC

Fibrous dysplasia/McCune-Albright syndrome: state-of-the-art advances, pathogenesis, and basic/translational research.

Orphanet journal of rare diseases

Palmisano B, Berry C, Boyce A, Charles JF, Collins MT, Corsi A, Fierro FA, Heegaard AM, van der Heijden H, Hoffman CS, Hopkins C, Upadhyay J, Wehn PM, Wentworth KL, Yang Y, Zhao X, Hsiao EC, Riminucci M

Update on the medical management of fibrous dysplasia of the bone.

Therapeutic advances in endocrinology and metabolism

Wentworth KL, Park J, Yu X, Hsiao EC

MMP-9 deficiency confers resilience in Fibrodysplasia Ossificans Progressiva in a man and mice.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Lounev V, Groppe JC, Brewer N, Wentworth KL, Smith V, Xu M, Schomburg L, Bhargava P, Al Mukaddam M, Hsiao EC, Shore EM, Pignolo RJ, Kaplan FS

AI is a viable alternative to high throughput screening: a 318-target study.

Scientific reports

Atomwise AIMS Program

Wnt pathway inhibition with the porcupine inhibitor LGK974 decreases trabecular bone but not fibrosis in a murine model with fibrotic bone.

JBMR plus

Lung H, Wentworth KL, Moody T, Zamarioli A, Ram A, Ganesh G, Kang M, Ho S, Hsiao EC

Etiology and Pathophysiology of Hypoparathyroidism: A Narrative Review.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Pasieka JL, Wentworth K, Yeo CT, Cremers S, Dempster D, Fukumoto S, Goswami R, Houillier P, Levine MA, Pasternak JD, Perrier ND, Sitges-Serra A, Shoback DM

Functional testing of BMP pathway variants identified on whole exome sequencing in a patient with delayed-onset fibrodysplasia ossificans progressiva (FOP) using ACVR1R206H -specific human cellular and zebrafish models.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Wentworth KL, Lalonde RL, Groppe JC, Brewer N, Moody T, Hansberry S, Taylor K, Shore EM, Kaplan FS, Pignolo RJ, Yelick PC, Hsiao EC

Identification of Risk Factors in the Development of Heterotopic Ossification after Primary Total Hip Arthroplasty.

The Journal of clinical endocrinology and metabolism

Singh S, Morshed S, Motamedi D, Kidane J, Paul A, Hsiao EC, Wentworth KL

An ACVR1 activating mutation causes neuropathic pain and sensory neuron hyperexcitability in humans.

Pain

Yu X, Ton AN, Niu Z, Morales BM, Chen J, Braz J, Lai MH, Barruet E, Liu H, Cheung K, Ali S, Chan T, Bigay K, Ho J, Nikolli I, Hansberry S, Wentworth K, Kriegstein A, Basbaum A, Hsiao EC

Social and clinical impact of COVID-19 on patients with fibrodysplasia ossificans progressiva.

Orphanet journal of rare diseases

Kou S, Kile S, Kambampati SS, Brady EC, Wallace H, De Sousa CM, Cheung K, Dickey L, Wentworth KL, Hsiao EC

Patients with ACVR1R206H mutations have an increased prevalence of cardiac conduction abnormalities on electrocardiogram in a natural history study of Fibrodysplasia Ossificans Progressiva.

Orphanet journal of rare diseases

Kou S, De Cunto C, Baujat G, Wentworth KL, Grogan DR, Brown MA, Di Rocco M, Keen R, Al Mukaddam M, le Quan Sang KH, Masharani U, Kaplan FS, Pignolo RJ, Hsiao EC

Surgical management of bilateral hip fractures in a patient with fibrodysplasia ossificans progressiva treated with the RAR-? agonist palovarotene: a case report.

BMC musculoskeletal disorders

Singh S, Kidane J, Wentworth KL, Motamedi D, Morshed S, Schober AE, Hsiao EC

Pocket change: a simple educational intervention increases hospitalist documentation of comorbidities and improves hospital quality performance measures.

Quality management in health care

Sparks R, Salskov AH, Chang AS, Wentworth KL, Gupta PP, Staiger TO, Anawalt BD

Three hospital admissions in 9 days to diagnose azathioprine hypersensitivity in a patient with Crohn's disease.

American journal of therapeutics

Mookherjee S, Narayanan M, Uchiyama T, Wentworth KL

Faculty development for hospitalists: structured peer observation of teaching.

Journal of hospital medicine

Mookherjee S, Monash B, Wentworth KL, Sharpe BA

Publications

Single-cell analysis of human fibrous dysplasia bone reveals a fibrotic transcriptome and GNAS variants in endothelial, perivascular, and stromal cells.

Fibrous dysplasia/McCune-Albright syndrome: state-of-the-art advances, pathogenesis, and basic/translational research.

Update on the medical management of fibrous dysplasia of the bone.

MMP-9 deficiency confers resilience in Fibrodysplasia Ossificans Progressiva in a man and mice.

AI is a viable alternative to high throughput screening: a 318-target study.

Wnt pathway inhibition with the porcupine inhibitor LGK974 decreases trabecular bone but not fibrosis in a murine model with fibrotic bone.

Etiology and Pathophysiology of Hypoparathyroidism: A Narrative Review.

Functional testing of BMP pathway variants identified on whole exome sequencing in a patient with delayed-onset fibrodysplasia ossificans progressiva (FOP) using ACVR1R206H -specific human cellular and zebrafish models.

Identification of Risk Factors in the Development of Heterotopic Ossification after Primary Total Hip Arthroplasty.

An ACVR1 activating mutation causes neuropathic pain and sensory neuron hyperexcitability in humans.

Social and clinical impact of COVID-19 on patients with fibrodysplasia ossificans progressiva.

Patients with ACVR1R206H mutations have an increased prevalence of cardiac conduction abnormalities on electrocardiogram in a natural history study of Fibrodysplasia Ossificans Progressiva.

Surgical management of bilateral hip fractures in a patient with fibrodysplasia ossificans progressiva treated with the RAR-? agonist palovarotene: a case report.

Advances in Models of Fibrous Dysplasia/McCune-Albright Syndrome.

New Frontiers in Osteoporosis Therapy.

Applying the Guidelines for Primary Hyperparathyroidism: The Path Not Taken.

Therapeutic advances for blocking heterotopic ossification in fibrodysplasia ossificans progressiva.

NF-?B/MAPK activation underlies ACVR1-mediated inflammation in human heterotopic ossification.

Clinical-pathological correlations in three patients with fibrodysplasia ossificans progressiva.

A Novel T55A Variant of Gs a Associated with Impaired cAMP Production, Bone Fragility, and Osteolysis.

Pocket change: a simple educational intervention increases hospitalist documentation of comorbidities and improves hospital quality performance measures.

Three hospital admissions in 9 days to diagnose azathioprine hypersensitivity in a patient with Crohn's disease.

Faculty development for hospitalists: structured peer observation of teaching.