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Hailyn Nielsen, MD, PhD

Asst. Professor

M_MED-CORE-RHEU

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I am a physician-scientist in the UCSF Division of Rheumatology. I keep a general rheumatology clinic at the Parnassus campus where I treat patients with autoimmune diseases. Additionally, I carry out post-doctoral research in the laboratory of Dr. Julie Zikherman also in the Division of Rheumatology. Broadly, my research involves using mouse models of autoimmunity to dissect molecular mechanisms of immune tolerance.

Publications

Nr4a1 and Nr4a3 redundantly control clonal deletion and contribute to an anergy-like transcriptome in auto-reactive thymocytes to impose tolerance in mice.

Nature communications

Nielsen HV, Yang L, Mueller JL, Ritter AJ, Hiwa R, Proekt I, Rackaityte E, Aylard D, Gupta M, Scharer CD, Anderson MS, Au-Yeung BB, Zikherman J

Molecular basis for potent B cell responses to antigen displayed on particles of viral size.

Nature immunology

Brooks JF, Riggs J, Mueller JL, Mathenge R, Wholey WY, Meyer AR, Yoda ST, Vykunta VS, Nielsen HV, Cheng W, Zikherman J

NR4A nuclear receptors in T and B lymphocytes: Gatekeepers of immune tolerance.

Immunological reviews

Hiwa R, Brooks JF, Mueller JL, Nielsen HV, Zikherman J

NR4A family members regulate T cell tolerance to preserve immune homeostasis and suppress autoimmunity.

JCI insight

Hiwa R, Nielsen HV, Mueller JL, Mandla R, Zikherman J

Drug and Vaccine Development for the Treatment and Prevention of Urinary Tract Infections.

Microbiology spectrum

O'Brien VP, Hannan TJ, Nielsen HV, Hultgren SJ

Significance of the D-serine-deaminase and D-serine metabolism of Staphylococcus saprophyticus for virulence.

Infection and immunity

Korte-Berwanger M, Sakinc T, Kline K, Nielsen HV, Hultgren S, Gatermann SG

Pilin and sortase residues critical for endocarditis- and biofilm-associated pilus biogenesis in Enterococcus faecalis.

Journal of bacteriology

Nielsen HV, Flores-Mireles AL, Kau AL, Kline KA, Pinkner JS, Neiers F, Normark S, Henriques-Normark B, Caparon MG, Hultgren SJ

Murine vaginal colonization model for investigating asymptomatic mucosal carriage of Streptococcus pyogenes.

Infection and immunity

Watson ME, Nielsen HV, Hultgren SJ, Caparon MG

The metal ion-dependent adhesion site motif of the Enterococcus faecalis EbpA pilin mediates pilus function in catheter-associated urinary tract infection.

mBio

Nielsen HV, Guiton PS, Kline KA, Port GC, Pinkner JS, Neiers F, Normark S, Henriques-Normark B, Caparon MG, Hultgren SJ

A reference map of the membrane proteome of Enterococcus faecalis.

Proteomics

Maddalo G, Chovanec P, Stenberg-Bruzell F, Nielsen HV, Jensen-Seaman MI, Ilag LL, Kline KA, Daley DO

Characterization of a novel murine model of Staphylococcus saprophyticus urinary tract infection reveals roles for Ssp and SdrI in virulence.

Infection and immunity

Kline KA, Ingersoll MA, Nielsen HV, Sakinc T, Henriques-Normark B, Gatermann S, Caparon MG, Hultgren SJ

G-CSF induction early in uropathogenic Escherichia coli infection of the urinary tract modulates host immunity.

Cellular microbiology

Ingersoll MA, Kline KA, Nielsen HV, Hultgren SJ