Christina Homer, MD, PhD | Women Physician-Scientists @UCSF

"Select and Resequence" Methods Enable a Genome-Wide Association Study of the Dimorphic Human Fungal Pathogen Coccidioides posadasii.

Genome biology and evolution

Voorhies M, Joehnk B, Uehling J, Walcott K, Dubin CA, Mead HL, Homer CM, Galgiani JN, Barker BM, Brem RB, Sil A

Phenotypic landscape of an invasive fungal pathogen reveals its unique biology.

Cell

Boucher MJ, Banerjee S, Joshi MB, Wei AL, Nalley MJ, Huang MY, Lei S, Ciranni M, Condon A, Langen A, Goddard TD, Caradonna I, Goranov AI, Homer CM, Mortensen Y, Petnic S, Reilly MC, Xiong Y, Susa KJ, Pastore VP, Zaro BW, Madhani HD

Transcriptomic atlas throughout Coccidioides development reveals key phase-enriched transcripts of this important fungal pathogen.

PLoS biology

Homer CM, Voorhies M, Walcott K, Ochoa E, Sil A

P-1017. Key Fungal Secreted Proteases in Coccidioidomycosis.

Open forum infectious diseases

Christina Homer, Elena Ochoa, Mark Voorhies, Anita Sil

Optimizing in vitro spherulation cues in the fungal pathogen Coccidioides.

mSphere

Homer CM, Ochoa E, Voorhies M, Sil A

Phenotypic landscape of a fungal meningitis pathogen reveals its unique biology.

bioRxiv : the preprint server for biology

Boucher M, Banerjee S, Joshi M, Wei A, Huang M, Lei S, Ciranni M, Condon A, Langen A, Goddard T, Caradonna I, Goranov A, Homer C, Mortensen Y, Petnic S, Reilly M, Xiong Y, Susa K, Pastore VP, Zaro B, Madhani H

Transcriptomic atlas of the morphologic development of the fungal pathogen Coccidioides reveals key phase-enriched transcripts.

bioRxiv : the preprint server for biology

Homer CM, Voorhies M, Walcott K, Ochoa E, Sil A

Inferring the composition of a mixed culture of natural microbial isolates by deep sequencing.

bioRxiv : the preprint server for biology

Voorhies M, Joehnk B, Uehling J, Walcott K, Dubin C, Mead HL, Homer CM, Galgiani JN, Barker BM, Brem RB, Sil A

Optimizing in vitro spherulation cues in the fungal pathogen Coccidioides.

bioRxiv : the preprint server for biology

Homer C, Ochoa E, Voorhies M, Sil A

Proteome-wide Humoral Immune Profiling in Central Nervous System Coccidioidomycosis Using Programmable Phage Display (S25.004).

Neurology

Christine L. Boutros, Ravi Dandekar, Mark Voorhies, Christina Homer, George R. Thompson, Satya Dandekar, Anita Sil, Michael R. Wilson

Embolic Hypodermic Needle Causing Traumatic Cardiac Tamponade: A Case Report.

Critical care explorations

Yen AF, Homer CM, Mohapatra A, Langnas E, Gomez A, Hendrickson CM

Polymerase pausing induced by sequence-specific RNA-binding protein drives heterochromatin assembly.

Genes & development

Parsa JY, Boudoukha S, Burke J, Homer C, Madhani HD

Genome-wide analysis of the regulation of Cu metabolism in Cryptococcus neoformans.

Molecular microbiology

Garcia-Santamarina S, Festa RA, Smith AD, Yu CH, Probst C, Ding C, Homer CM, Yin J, Noonan JP, Madhani H, Perfect JR, Thiele DJ

Polymerase pausing induced by sequence-specific RNA binding protein drives heterochromatin assembly.

bioRxiv

Jahan-Yar Parsa, Selim Boudoukha, Jordan Burke, Christina Homer, Hiten Madhani

The histone variant H2A.Z promotes splicing of weak introns.

Genes & development

Nissen KE, Homer CM, Ryan CJ, Shales M, Krogan NJ, Patrick KL, Guthrie C

Integrated Activity and Genetic Profiling of Secreted Peptidases in Cryptococcus neoformans Reveals an Aspartyl Peptidase Required for Low pH Survival and Virulence.

PLoS pathogens

Clarke SC, Dumesic PA, Homer CM, O'Donoghue AJ, La Greca F, Pallova L, Majer P, Madhani HD, Craik CS

Phospho-site mutants of the RNA Polymerase II C-terminal domain alter subtelomeric gene expression and chromatin modification state in fission yeast.

Nucleic Acids Research

Inada M, Nichols RJ, Parsa JY, Homer CM, Benn RA, Hoxie RS, Madhani HD, Shuman S, Schwer B, Pleiss JA

Intracellular Action of a Secreted Peptide Required for Fungal Virulence.

Cell host & microbe

Homer CM, Summers DK, Goranov AI, Clarke SC, Wiesner DL, Diedrich JK, Moresco JJ, Toffaletti D, Upadhya R, Caradonna I, Petnic S, Pessino V, Cuomo CA, Lodge JK, Perfect J, Yates JR, Nielsen K, Craik CS, Madhani HD

Product binding enforces the genomic specificity of a yeast polycomb repressive complex.

Cell

Dumesic PA, Homer CM, Moresco JJ, Pack LR, Shanle EK, Coyle SM, Strahl BD, Fujimori DG, Yates JR, Madhani HD

RNA-directed remodeling of the HIV-1 protein Rev orchestrates assembly of the Rev-Rev response element complex.

eLife

Jayaraman B, Crosby DC, Homer C, Ribeiro I, Mavor D, Frankel AD

Using a Transcriptional Network to Approach the Mechanism of Fungal Meningitis.

Biophysical journal

Christina M. Homer, Alexi Goranov, Dan Santos, Ippolito Caradonna, Sarah Petnic, Hiten D. Madhani

Mutation of the His ligand in mitoNEET stabilizes the 2Fe-2S cluster despite conformational heterogeneity in the ligand environment.

Acta crystallographica. Section D, Biological crystallography

Conlan AR, Paddock ML, Homer C, Axelrod HL, Cohen AE, Abresch EC, Zuris JA, Nechushtai R, Jennings PA

Structural Basis for Phosphate Stabilization of the Uniquely Coordinated 2Fe-2S Cluster of the Outer Mitochondrial Membrane Protein MitoNEET.*.

Biophysical journal

Christina Homer, David Yee, Herbert L. Axelrod, Aina E. Cohen, Edward C. Abresch, Charlene Chang, Rachel Nechushtai, Patricia A. Jennings, Mark L. Paddock

Publications