Bridget Keenan, MD, PhD

Assistant Professor
Cancer Immunotherapy Program
Division of Hematology/Oncology
Department of Medicine
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Dr. Keenan completed her MD and PhD at the Johns Hopkins University School of Medicine, where she focused on using cancer vaccines to overcome immune suppression in the tumor microenvironment in mouse models of pancreatic cancer. She completed her Internal Medicine residency and Hematology/Oncology fellowship at UCSF. During her fellowship, she trained in both gastrointestinal oncology and cancer immunotherapy. She is the Co-Director of the Cancer Immunotherapy Program and Medical Director of the Cancer Immunotherapy Clinic. Her research interests are in studying the mechanisms of response and resistance to immunotherapy, with a focus on gastrointestinal cancers. Clinically, she sees patients with solid tumor malignancies being treated with cutting-edge immunotherapies including cell therapies and T cell engagers.

Publications

TIMEPOINT, a phase 1 study combining MTL-CEBPA with pembrolizumab, supports the immunomodulatory effect of MTL-CEBPA in solid tumors.

Cell reports. Medicine

Plummer R, Sodergren MH, Hodgson R, Ryan BM, Raulf N, Nicholls JP, Reebye V, Voutila J, Sinigaglia L, Meyer T, Pinato DJ, Sarker D, Basu B, Blagden S, Cook N, Jeffrey Evans TR, Yachnin J, Chee CE, Li D, El-Khoueiry A, Diab M, Huang KW, Pai M, Spalding D, Talbot T, Noel MS, Keenan B, Mahalingam D, Song MS, Grosso M, Arnaud D, Auguste A, Zacharoulis D, Storkholm J, McNeish I, Habib R, Rossi JJ, Habib NA

ATHENA: A phase 1/2 study of AZD5851, a chimeric antigen receptor (CAR) T-cell therapy directed against GPC3 in adult patients with advanced/recurrent hepatocellular carcinoma (HCC).

Journal of Clinical Oncology

Ashley Hamilton, Robin Kate Kelley, Daneng Li, Ignacio Melero Bermejo, Ghassan K. Abou-Alfa, Olatunji B. Alese, Raed Moh'd Taiseer Al-Rajabi, Hani M. Babiker, Mitesh Borad, Farshid Dayyani, Martin Gutierrez, Jung Yong Hong, Lionel Aurelien Kankeu Fonkoua, Thomas Benjamin Karasic, Adel Kardosh, Bridget P. Keenan, Anne M. Noonan, Anwaar Saeed, Attilio Bondanza, John Stone

Phase II study of pembrolizumab plus capecitabine and bevacizumab in microsatellite stable (MSS) metastatic colorectal cancer (mCRC).

Journal of Clinical Oncology

Andrea Grace Bocobo, Renee Wang, Spencer Behr, Julia C. Carnevale, Pelin Cinar, Eric Andrew Collisson, Lawrence Fong, Bridget P Keenan, Wesley Allen Kidder, Andrew H. Ko, Kanti Pallav Kolli, Megan Kennedy, Angela Laffan, Sorbarikor Piawah, Marin Pollak, Gabriel Schwartz, Julia Whitman, Li Zhang, Katherine Van Loon, Chloe Evelyn Atreya